Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,967

Sort By: Relevance

$110K - $140K *

Empower customer success by leading onboarding, optimizing solutions, and driving value through technical expertise. Build trust and advocate for clients while enhancing service delivery and collabora...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $230K *

Lead the charge in advancing oncology care by building strong relationships with key stakeholders, driving product adoption, and ensuring patient access to innovative therapies in a dynamic biopharma...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Join a dynamic team as you manage oncology product promotions, build relationships with key stakeholders, and drive brand value through strategic engagement and innovative solutions in a competitive b...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the execution of complex client programs, ensuring timely delivery and budget adherence. Collaborate with cross-functional teams to drive accountability and clarity, while proactively managing ri...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$140K - $175K *

Empower scientific innovation by collaborating within product pods to develop and evaluate real-world evidence agents. Drive impactful research and ensure scientific rigor while partnering with indust...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $140K *

Accelerate progress at our organization by leading demand generation strategies, optimizing campaigns across various channels, and collaborating with cross-functional teams to drive qualified pipeline...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$150K - $180K *

Engineer advanced protein design models and collaborate with experts to innovate in AI Drug Discovery, driving the development of candidate antibody therapeutics through deep learning and systems biol...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$102K - $170K *

Accelerate progress at transforming data solutions by building production-grade assets. Leverage your expertise in data engineering and business fluency to create trusted, reusable data products that...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $200K *

Shape the future of data solutions as a Database Support Engineer, driving customer success through onboarding, technical support, and collaboration with sales teams to enhance product adoption and op...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $251K *

Pioneer innovative technology strategies and architectural solutions across Agile teams, driving AI-enabled engineering transformation and ensuring scalable, secure, and maintainable solutions for ent...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$68K - $102K *

Drive your career with a dynamic role in global benefits administration, ensuring compliance and enhancing employee wellness programs. Collaborate with vendors and support Total Rewards initiatives wh...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$115K - $130K *

Lead the charge in optimizing search channels for diverse clients, managing a global team while driving SEO, PPC, GEO, and AIO strategies. Ensure performance efficiency and deliver insightful reportin...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$210K - $250K *

Innovate in AI-native primary care by leading a dynamic medical group. Manage physicians, enhance care delivery, and shape clinical programs while maintaining direct patient care involvement. Drive ex...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$210K *

Lead the charge in managing IT projects for our enterprise payments ecosystem. Collaborate with technical teams to develop detailed project plans, ensuring successful execution and alignment with busi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$94K - $118K *

Unlock your potential by managing a comprehensive benefits program, ensuring compliance, and enhancing employee experience. Collaborate with cross-functional teams to streamline operations and support...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$130K - $133K *

Advance clinical research by leading site monitoring and management efforts. Ensure compliance with regulatory standards while overseeing study protocols and data integrity. Collaborate with teams to...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$190K - $315K *

Shape the future of visual design for an enterprise design system, leading the evolution of its visual language and guiding teams to create consistent, high-quality experiences across products and maj...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$125K - $150K *

Unlock potential by leading the development of innovative AI solutions that transform complex learning workflows into impactful autonomous agents, collaborating closely with strategic clients to shape...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$238K - $280K *

Lead the charge in developing autonomous attack workflows for external surfaces, leveraging your expertise to enhance reconnaissance capabilities and mentor engineers while driving strategic technical...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$206K - $242K *

Transform external attack capabilities by developing scalable workflows and automating reconnaissance processes. Drive innovation in offensive security, mentor teammates, and contribute to a high-impa...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$200K - $250K *

Empower growth in the cybersecurity sector by driving sales, acquiring new accounts, and fostering strong customer relationships. Leverage your expertise to introduce innovative solutions and exceed s...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$90K - $110K *

Champion project success by leading Microsoft D365 implementations and website development. Collaborate with cross-functional teams to ensure compliance and deliver high-quality results while managing...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Accelerate progress at the forefront of power connector innovation, leading product development initiatives while driving cross-functional collaboration and mentoring engineering talent to deliver hig...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$172K - $287K *

Join us to shape the future of pharmacy by leading product strategy and innovation. Drive growth and commercialization for a diverse portfolio of healthcare technology solutions, influencing enterpris...

RemoteRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive project delivery excellence by architecting frameworks, managing resources, and synchronizing teams. Lead cross-functional initiatives, optimize processes, and mentor project managers to ensure...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.