Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From positions in Jackson and the Gulf Coast to opportunities in communities across the state, find roles that match your experience, skills, and career goals.

Professional Opportunities Across Mississippi

Mississippi employers hire experienced professionals across industries such as healthcare, finance, manufacturing, technology, energy, and business operations. Available roles and compensation vary by employer, location, and qualifications, so review each listing for details about responsibilities, salary, and requirements.

Search in Mississippi Cities and Regions

Find opportunities in major employment centers including Jackson, Gulfport, and Southaven, as well as other Mississippi communities. Use location and job-title filters to focus your search, and consider remote or hybrid listings when available.

Find a Role That Fits Your Career

Compare opportunities by seniority, specialty, and work arrangement. Keep your résumé current, highlight measurable results, and tailor your application to the qualifications in each listing. Ladders helps professionals explore vetted jobs with salaries of at least $100,000.

Start Your Mississippi Job Search

Browse Mississippi jobs on Ladders and take the next step toward a professional opportunity aligned with your expertise and compensation goals. Listings change frequently, so check back for new roles.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,063

Sort By: Relevance

$75K - $150K *

Drive branch operations by leading teams to achieve financial goals, enhance customer service, and implement strategic initiatives. Collaborate across departments to optimize performance and foster a...

Today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$145K - $220K *

Shape the future of Finance by managing AI transformation initiatives, collaborating with stakeholders to identify high-value use cases, and ensuring successful integration of AI solutions within Fina...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Information Technology

$80K - $95K *

Elevate your career by managing clinical sites and ensuring study quality, patient safety, and regulatory compliance. Collaborate with site teams to support enrollment and deliver impactful clinical r...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$121K - $170K *

Lead the transformation of storage solutions by leveraging deep technical expertise in NetApp Keystone and Storage-as-a-Service. Collaborate with customers to architect tailored solutions that optimiz...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$105K - $150K *

Champion your career as you lead data engineering initiatives, ensuring successful project implementation and high client satisfaction. Collaborate with teams to transform analytics data into actionab...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$91K - $128K *

Join a team that's dedicated to empowering educators through impactful training sessions. You'll create engaging content and deliver customized Google for Education engagements, enhancing customer rel...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$136K - $181K *

Drive innovation by optimizing Clinical Operations through digital solutions, enhancing productivity across clinical trial phases while ensuring stakeholder collaboration and strategic alignment with...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$176K - $236K *

Lead the charge in global regulatory project management, driving oncology strategies and submissions across regions. Collaborate with cross-functional teams to ensure compliance and timely market acce...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$114K - $154K *

Transform supply chain operations by managing SAP systems and processes, ensuring seamless logistics and distribution support. Drive efficiency and issue resolution across Commercial and Clinical Supp...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$178K - $238K *

Drive impactful oncology drug development by leading program management, optimizing team efficiency, and ensuring strategic alignment across global projects to enhance patient outcomes and organizatio...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$97K - $165K *

Shape the future of cloud solutions by leading technical relationships, validating AWS architectures, and driving presales strategies. Empower teams through mentorship while ensuring secure, scalable...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Business Services

$121K - $206K *

Lead the charge in architecting and delivering Microsoft Azure and 365 solutions for SMBs. Oversee cloud migrations, security implementations, and project management while fostering strong partner rel...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Business Services

$105K - $149K *

Drive security excellence by enhancing data protection and detection capabilities. Collaborate with cross-functional teams to implement DLP policies, automate processes, and ensure enterprise systems...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Finance & Insurance

$99K - $117K *

Lead strategic commercial initiatives to enhance performance and profitability across a portfolio of franchised hotels. Collaborate with stakeholders to drive revenue growth, optimize market share, an...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Hospitality & Recreation

$115K - $135K *

Drive impactful sales analytics by developing methodologies that enhance performance insights, forecasting, and strategic planning. Collaborate with stakeholders to translate complex data into actiona...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Hospitality & Recreation

$115K - $175K *

Advance market share by driving strategic growth initiatives within the US Mid-Market and Enterprise carrier segments. Lead a high-performing team to execute regional plans, leveraging deep telecom ex...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Media

$150K - $250K *

Lead the charge in driving sales and building relationships within the roofing industry. As a key liaison, you'll connect with contractors and clients to promote GAF's residential products, ensuring s...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$212K - $318K *

Shape the future of patient-centered outcomes in oncology by leading global strategies for clinical assessments and patient experience data, ensuring impactful evidence generation and regulatory succe...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$121K - $182K *

Manage clinical monitoring activities for multiple trials, providing mentorship and oversight to CRAs. Collaborate with teams to ensure compliance and quality, while addressing site-level issues and e...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $140K *

Unlock potential by bridging technical radio frequency capabilities with US Air Force needs. Collaborate with engineering and business teams to demonstrate and support advanced communication solutions...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$100K - $140K *

Support the U.S. Marine Corps by bridging technical radio capabilities with defense needs. Collaborate with engineering teams to demonstrate and evaluate advanced communication systems in diverse oper...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$100K - $140K *

Join a team that's redefining tactical communications for defense applications. Leverage your engineering expertise to bridge technical capabilities with USSOCOM requirements, supporting innovative so...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$71K - $99K *

Join a team that's dedicated to enhancing clinical practices through effective IT solutions. This role involves training, system maintenance, and collaboration with healthcare professionals to optimiz...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Empower client success by managing complex health plan accounts and fostering trusted relationships with stakeholders, ensuring optimal outcomes while navigating challenges in a dynamic healthcare env...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$119K - $149K *

Innovate with us to shape the future of mobile experiences. As a Senior Mobile Engineer, you'll drive the development of high-quality iOS applications, collaborating across teams to ensure performance...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of jobs can I find in Mississippi on Ladders?question toggle

    You can explore professional opportunities across fields such as healthcare, finance, manufacturing, technology, energy, and business operations. Roles and availability vary over time.

  • Are Mississippi jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional jobs that pay $100,000 or more. Check each listing for compensation details, qualifications, and other job-specific information.

  • Where in Mississippi can I search for jobs?question toggle

    Search across the state, including employment centers such as Jackson, Gulfport, and Southaven. You can use location filters to narrow results.

  • How can I find remote or hybrid jobs based in Mississippi?question toggle

    Use available work-arrangement filters or review listing details to identify remote and hybrid opportunities. Availability depends on the employer and role.

  • How do I improve my chances of getting hired for a Mississippi job?question toggle

    Tailor your résumé to the role, emphasize relevant experience and measurable outcomes, and ensure you meet the listed qualifications before applying.