Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,967

Sort By: Relevance

$95K - $115K *

Deliver innovative Appian solutions by developing, enhancing, and maintaining applications while supporting modernization initiatives in a collaborative Agile environment. Troubleshoot issues and ensu...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$82K - $229K *

Lead the charge in managing creative projects from inception to delivery, ensuring alignment with brand standards. Collaborate across teams to optimize workflows and maintain quality control for all a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$124K - $149K *

Reimagine player engagement by designing innovative reward systems that enhance gameplay experiences. Collaborate with a dynamic team to create compelling content that captivates and retains players i...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$150K - $180K *

Champion the security strategy for a cutting-edge platform, focusing on supply chain security, code scanning, and threat modeling. Collaborate with teams to enhance security practices and drive innova...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$135K - $160K *

Lead the charge in shaping innovative Network Observability products, driving strategy from concept to launch. Collaborate with cross-functional teams to deliver solutions that empower operators to op...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$300K - $350K *

Transform your career by leading a national body imaging service line, optimizing workflows, and enhancing clinical quality standards while mentoring a dedicated team of radiologists across multiple l...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$100K - $120K *

Transform utility project estimating through advanced analysis, mentoring, and collaborative support. Provide best-in-class service, ensuring accuracy and efficiency in project estimations while guidi...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$115K - $140K *

Unlock potential by leading product development for Salesforce Health Cloud solutions. Collaborate with cross-functional teams to prioritize and deliver impactful software that enhances patient servic...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$210K - $250K *

Champion transformative data strategies and lead technical pursuits in AI and data migration. Drive client success and practice growth while enhancing market presence through strategic partnerships an...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $150K *

Lead a dynamic team of Solutions Consultants, driving sales success through hands-on leadership, strategic deal support, and continuous improvement in a fast-paced environment focused on HR tech solut...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$135K - $155K *

Join a team that's dedicated to enhancing clinical workflows in Radiation Oncology. As a Clinical Success Manager, you'll train clinics, solve problems, and foster relationships to ensure customer sat...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$68K - $93K *

Join a team that's dedicated to driving sales and enhancing customer relationships in the animal health sector. Utilize innovative strategies and digital tools to maximize performance and deliver exce...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$180K - $210K *

Transform technology operations by leading strategic initiatives, enhancing cybersecurity, and fostering cross-functional collaboration to support mission-driven projects and a remote-first workforce...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$118K - $174K *

Champion innovative ERP solutions, translating complex business needs into effective technical strategies. Lead architecture, customization, and integration efforts while optimizing system performance...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$82K - $115K *

Innovate faculty management and student engagement strategies while coaching and supporting educators. Drive academic excellence and uphold performance standards within a dynamic educational environme...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$109K - $164K *

Champion patient care by conducting in-home assessments and managing acute and chronic conditions. Collaborate with a dedicated care team to provide comprehensive support and education, ensuring optim...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$140K - $170K *

Advance project execution by managing vendor relationships and internal teams to deliver a new web-based application. Oversee timelines, risks, and stakeholder alignment to ensure successful project o...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Staffing

$98K - $157K *

Shape comprehensive sales support strategies by managing estimation, bidding, and proposal processes. Collaborate with sales teams to align offerings with customer requirements and ensure adherence to...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Join a team that's dedicated to ensuring the quality and safety of clinical trials. As a Senior Clinical Research Associate, you'll manage site relationships, oversee monitoring activities, and contri...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Elevate customer engagement by providing expert technical training and consulting. Collaborate with sales teams to enhance product understanding and drive growth through tailored demonstrations and su...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$150K - $230K *

Drive impactful oncology solutions by building relationships with key stakeholders. Collaborate with internal teams to enhance patient access and exceed performance goals while managing territory reso...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Join a team that's transforming oncology care by promoting innovative treatments and building strong relationships with healthcare professionals. Drive brand value and ensure patient access while lead...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$101K - $132K *

Join a team that's at the forefront of client success by leading implementation efforts. Drive operational excellence while mentoring your team and collaborating cross-functionally to enhance customer...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $230K *

Drive impactful oncology solutions by building strong relationships with key stakeholders, promoting innovative products, and exceeding performance goals in a dynamic biopharma environment. Your exper...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Engage key stakeholders in oncology by promoting innovative products, building relationships, and driving access to care. Lead strategic initiatives to exceed performance goals while embodying corpora...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.