Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
Average Salary: $110,967
Software Engineer II, Engineering
$125K - $145K *
Lead the charge in building impactful software features that enhance educators' management of English Learner programs, taking ownership from design to operation in a full-stack environment utilizing...
Reposted 1 week ago
Senior Global Product Compliance Specialist
$135K - $180K *
Drive compliance excellence by managing global product projects across diverse markets. Collaborate with teams to ensure adherence to regulations for dietary supplements, foods, cosmetics, and medical...
1 week ago
$100K - $125K *
Accelerate progress at our financial reporting function by leading compliance, ensuring accurate statements, and mentoring a skilled team. Drive technical accounting excellence and support executive d...
1 week ago
Program Manager - Data Center Construction
$110K - $130K *
Lead the execution of large-scale data center projects, ensuring strategic alignment with client goals while managing complex deliveries across multiple sites, budgets, and timelines...
Reposted 1 week ago
Lead Business Systems Analyst (Remote) - The Toro Company
$103K - $139K *
Elevate business processes by leading SAP Sales and Distribution solutions. Collaborate with stakeholders to analyze, design, and implement integrated systems, ensuring effective communication and pro...
1 week ago
Director Underwriting - Remote
$124K - $211K *
Transform your career by leading underwriting teams, driving pricing strategies, and ensuring financial performance. Collaborate across departments to influence business growth and deliver sustainable...
1 week ago
Clinical Program Pharmacist Principal- REMOTE
$124K - $211K *
Innovate clinical product strategies by analyzing market data and collaborating across departments. Drive product development and regulatory compliance while enhancing clinical initiatives to ensure c...
1 week ago
$92K - $138K *
Lead the strategic management of accounts receivable functions, optimizing cash flow and ensuring compliance. Collaborate with teams to enhance efficiency, resolve escalations, and drive performance a...
1 week ago
Senior Product Manager, Epic Optimization
$101K - $152K *
Champion innovative solutions by leveraging Epic expertise to enhance operational efficiency and drive strategic initiatives across healthcare environments, ensuring high-performance standards and cli...
1 week ago
Senior Denials Prevention Process Improvement Advisor
$68K - $103K *
Shape the future of revenue cycle management by driving process improvements and reducing denials. Collaborate with teams to analyze trends, implement best practices, and enhance client satisfaction t...
1 week ago
$95K - $115K *
Drive successful public-sector construction projects by managing scope, schedule, and budget while fostering strong client relationships and ensuring quality delivery from inception to closeout...
1 week ago
Principal Product Manager, Product Development Platforms
$173K - $290K *
Champion innovation in product development platforms, driving strategy and execution for AI-first tools that enhance collaboration and efficiency across teams. Lead the evolution of platforms, ensurin...
1 week ago
Principal Applied Scientist (User Modeling)
$195K - $312K *
Advance user modeling by driving complex AI projects end-to-end, collaborating with cross-functional teams to translate cutting-edge research into impactful solutions for home shopping experiences...
1 week ago
$255K - $300K *
Join a team that's redefining enterprise sales by owning the full sales cycle, engaging C-suite executives, and driving impactful solutions in a fast-paced environment. Your consultative approach will...
1 week ago
Senior Oncology Account Manager (Louisiana)
$210K - $235K *
Unlock your potential by driving sales performance and building relationships in oncology. Collaborate cross-functionally to support the launch of varegacestat, ensuring patient-centric care and achie...
1 week ago
Senior Software Engineer, Web Platform
$190K - $267K *
Join a team that's redefining web performance and developer experience. You'll tackle complex platform challenges, optimize Shreddit’s architecture, and enhance tooling for a high-traffic site, empowe...
1 week ago
$69K - $101K *
Empower our Micro-Fulfillment Operations team by ensuring optimal performance and reliability of automated systems. Engage with customers to troubleshoot and resolve complex technical issues, enhancin...
1 week ago
Staff Product Manager, Technical
$160K - $220K *
Lead the charge in defining product strategy and delivery for major client engagements. Collaborate with cross-functional teams, mentor PMs, and navigate complex challenges to ensure successful outcom...
1 week ago
Associate Director, Thought Leader Liaison, Oncology - Central
$157K - $256K *
Champion strategic engagements with oncology thought leaders to enhance insights and drive initiatives for our Solid Tumor portfolio, focusing on collaboration across teams and executing regional stra...
1 week ago
Senior Manager, Corporate Strategy
$125K - $150K *
Empower strategic decision-making by driving data analysis and recommendations. Collaborate with senior leadership to shape initiatives, build financial models, and leverage AI tools, ensuring impactf...
1 week ago
Director, Project Controls, Project & Development Services (Data Centers)
$161K - $190K *
Drive strategic planning and scheduling for large-scale capital programs, focusing on data center delivery. Lead teams, establish best practices, and influence stakeholders to ensure successful projec...
1 week ago
Associate Manager Enterprise RFP Operations
$87K - $136K *
Shape the future of enterprise operations by leading a dynamic team to craft compelling RFP responses, ensuring compliance and strategic alignment while driving productivity and process improvements a...
1 week ago
Technical Account Manager - Texas, Colorado or Illinois
$170K - $200K *
Drive customer success by managing the entire lifecycle, from onboarding to renewal. Collaborate with teams to enhance platform adoption, ensure value realization, and build foundational processes as...
1 week ago
$80K - $95K *
Elevate project outcomes by leading VDC initiatives, driving innovation, and enhancing collaboration across teams. Utilize advanced modeling techniques to optimize workflows and mentor team members fo...
1 week ago
Senior Financial Analyst, Treasury
$99K - $132K *
Advance your career as a Senior Financial Analyst in Treasury, focusing on cash management, corporate finance, and cross-functional collaboration. Drive impactful financial strategies while enhancing...
1 week ago
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.