Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,974

Sort By: Relevance

$66K - $102K *

Elevate your career by joining our consulting team to design and implement SAP PP/QM solutions, driving value for clients through innovative strategies and expert knowledge transfer in a dynamic, glob...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$73K - $102K *

Bring your expertise to enhance ERP solutions by collaborating with stakeholders, customizing modules, and ensuring seamless integration while maintaining compliance and performance standards...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$140K - $180K *

Shape the future of clinical quality assurance by overseeing trials, ensuring compliance with GCP and ICH standards, and driving operational excellence across clinical activities within a cross-functi...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$83K - $93K *

Join a team that's dedicated to servicing and repairing CNC machine tools. Perform complex diagnostics and repairs, ensuring operational excellence through customer interaction, advanced troubleshooti...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$275K - $405K *

Transform developer engagement by leading a global team that inspires and equips developers. Drive strategic initiatives, foster community, and enhance Twilio's presence in the developer ecosystem thr...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Transportation

$114K - $167K *

Lead the charge in optimizing ERP solutions by analyzing complex business processes, designing customizations, and implementing integration workflows to enhance performance and compliance across vario...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$106K - $167K *

Join a team that's redefining ERP solutions by analyzing complex business processes, developing custom architectures, and leading data migrations to optimize performance and compliance across diverse...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$107K - $144K *

Lead and execute comprehensive quality assurance for Workday implementations, ensuring alignment with business needs and high-quality outcomes. Oversee testing strategies, manage defect lifecycles, an...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$80K - $105K *

Engage in frontline cyber investigations to safeguard AI systems from malicious threats. Analyze flagged telemetry, evaluate cyber prompts, and enhance automated safety classifiers while collaborating...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$78K - $120K *

Drive the optimization of our Salesforce platform, ensuring user support and seamless configuration management. Collaborate to implement solutions and enhance security protocols while staying current...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$90K - $110K *

Lead the charge in transforming the HR department through strategic oversight and operational excellence. You will guide various HR functions, ensure policy compliance, and enhance organizational effe...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$125K - $150K *

Bring your expertise to drive revenue growth in healthcare through consultative sales and strategic partnerships. Own the full sales cycle, collaborate cross-functionally, and mentor future hires in a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $165K *

Empower clients by leveraging technical expertise to demonstrate product value, cultivate relationships, and drive sales success through effective communication and strategic engagement with stakehold...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Drive the strategic vision for Technical Support, enhancing service delivery and operational efficiency while championing AI transformation and innovation to elevate customer experience and achieve bu...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$120K - $150K *

Lead the strategic alignment of R&D and IT, ensuring compliance and scalability of Veeva systems. Drive technology roadmaps, manage vendor relationships, and mentor junior partners while enhancing reg...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$200K - $275K *

Lead the development of off-board AI evaluation frameworks to optimize safety and performance for autonomous vehicles. Collaborate with cross-functional teams to design scalable systems and enhance di...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Transportation

$110K - $130K *

Unlock your potential by driving sales of innovative pulmonary solutions. Collaborate with diverse stakeholders to enhance patient care and achieve sales targets in a dynamic healthcare environment. J...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Lead the charge in architecting and deploying AI solutions within enterprise teams, ensuring robust system performance and client satisfaction through hands-on engineering and consulting expertise...

Jackson, MSRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$229K - $310K *

Drive project management and business development to enhance operational efficiency in life sciences R&D, while leading diverse teams and ensuring profitability through strategic customer engagement a...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Transform enterprise learning by leading a team to design impactful solutions. Drive employee development, align training with business goals, and optimize learning technologies for enhanced performan...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Unlock potential by leading strategic initiatives in supply chain management for submarine production, focusing on risk identification, supplier engagement, and innovative solutions to enhance industr...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Business Services

$73K - $101K *

Unlock potential by leading installation, maintenance, and repair of low voltage power distribution systems. Collaborate with teams to ensure safety and efficiency while delivering exceptional service...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$69K - $96K *

Unlock potential by providing expert installation, maintenance, and repair of low voltage power distribution systems. Collaborate with teams to ensure safety and efficiency in mission-critical environ...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Shape the future of sales enablement by building a robust function from the ground up. Drive onboarding, training, and process adoption while leveraging analytics to enhance productivity and CRM usage...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

$90K - $110K *

Lead compassionate, patient-centered care for individuals with serious illnesses. Collaborate with interdisciplinary teams to enhance quality of life through expert symptom management and advance care...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.