Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,974

Sort By: Relevance

$143K - $208K *

Join a dynamic team as you lead enterprise-wide manufacturing strategy, ensuring performance and scalability across multiple facilities while driving cross-functional collaboration and continuous impr...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$68K - $97K *

Unlock potential by delivering innovative designs that elevate brand identity. Collaborate on strategic campaigns, mentor junior designers, and lead complex projects from concept to execution, all whi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$194K - $361K *

Lead the development of innovative NovaOS capabilities, ensuring alignment with business goals and driving continuous improvement through collaboration across cross-functional teams. Deliver measurabl...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Elevate your career by resolving complex commercial property losses, managing national accounts, and providing expert insights. Collaborate with diverse stakeholders while ensuring compliance and main...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$133K - $184K *

Join a team that's enhancing threat detection and response capabilities. As a hands-on technical leader, you'll drive security initiatives across cloud, infrastructure, and identity platforms, while m...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Elevate your career by driving sales in the SLED sector. Collaborate with partners, manage accounts, and execute strategies to exceed quotas while building lasting relationships with state agencies. Y...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$129K - $210K *

Empower organizations by designing scalable data management solutions, collaborating with customers and partners to drive adoption and success. Act as a key technical advisor, bridging teams to ensure...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$135K - $160K *

Lead the charge in building AI-powered engineering systems that enhance developer workflows, ensuring reliability and ease of adoption for engineers. Collaborate with teams to create innovative soluti...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$132K - $198K *

Elevate quality assurance practices by leading test strategy and execution for customer implementations. Collaborate with teams to enhance product quality, mitigate risks, and establish scalable testi...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$162K - $203K *

Transform your career by engaging with key opinion leaders in Urology and Women's Health. Leverage your scientific expertise to drive medical strategies and foster relationships that enhance product u...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$156K - $212K *

Engage with the medical community as a scientific liaison, fostering relationships with key experts and clinicians. Communicate vital scientific information and collaborate across teams to address unm...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$105K - $149K *

Transform complex Consumer-Directed Health implementations for major employers. Lead strategy, execution, and client engagement while serving as a subject-matter expert to ensure operational excellenc...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $145K *

Shape the future of avionics sales by leading business development efforts, engaging military and commercial aerospace customers, and driving strategic growth in the Americas through innovative test s...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$90K - $110K *

Lead the charge in delivering comprehensive patient care as a Nurse Practitioner, collaborating with healthcare teams to ensure effective diagnosis, treatment, and education while maintaining high sta...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Join a dynamic healthcare team to provide comprehensive patient care, ensuring effective diagnosis, treatment, and education. Collaborate with multidisciplinary teams to enhance patient outcomes while...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Advance patient care by examining and treating individuals independently while collaborating with healthcare teams. Utilize your expertise to ensure effective diagnosis, treatment, and education, all...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Pioneer the strategy and execution of data platforms and AI products, leading cross-functional teams to enhance commercial life sciences solutions while driving revenue growth and product adoption in...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$78K - $120K *

Transform claims operations as you empower clients by driving adoption of innovative solutions, optimizing processes, and enhancing business outcomes in the First Party Casualty landscape across vario...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Lead the charge in delivering exceptional dental care while utilizing cutting-edge technology. Join a dedicated team focused on patient satisfaction and professional growth in a supportive environment...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$81K - $110K *

Lead the transformation of patient care by enhancing utilization review processes, ensuring quality documentation, and collaborating with healthcare teams to optimize clinical outcomes and financial p...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$61K - $101K *

Unlock potential by joining a dynamic team focused on financial management, internal controls, and fraud risk. Collaborate with federal clients to enhance processes and drive measurable outcomes in au...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$240K - $300K *

Pioneer a luxury automotive experience as you lead operations, drive sales, and cultivate client relationships in a unique, single-point Porsche dealership. Own the financials and team dynamics while...

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$55K - $118K *

Champion a consultative sales approach to engage homeowners, guiding them through the partnership process. Leverage inbound leads to drive conversions and manage a dynamic sales pipeline, contributing...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$80K - $95K *

Join a team that's redefining virtual fundraising by leading innovative campaigns that engage diverse audiences, cultivate partnerships, and drive sustainable revenue growth, all while supporting a me...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$150K - $170K *

Unlock the potential of enterprise data architecture by designing secure, scalable solutions for employee data using Databricks. Collaborate with cross-functional teams to implement governance, compli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.