Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$82K - $123K *

Champion AI innovation by driving tool adoption, engineering practices, and workforce enablement across the enterprise. Collaborate with cross-functional teams, influencing leaders and building future...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$71K - $119K *

Drive customer success by leveraging expertise in intellectual property solutions, enhancing product adoption, and delivering exceptional experiences through strategic engagement and training initiati...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$113K - $188K *

Contribute to innovative Salesforce solutions by leveraging your development expertise. Collaborate with cross-functional teams to design, build, and maintain scalable applications, ensuring high perf...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$74K - $124K *

Drive innovation by enhancing Power Platform tools for executive-level operations. Manage full lifecycle processes, ensuring compliance and improving operational efficiency through workflow automation...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$80K - $95K *

Drive success in the SLED sector by managing accounts, building relationships, and executing sales strategies. Collaborate with partners to maintain a robust revenue pipeline while achieving quotas an...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Unlock potential by driving sales in the supply chain and food & beverage sector. Foster strong client relationships, develop tailored marketing strategies, and exceed quotas through innovative busine...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$151K - $237K *

Transform healthcare outcomes by engaging with KOLs and HCPs, analyzing scientific data, and fostering expert networks. Drive medical strategy and enhance patient care through compliant, insightful co...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Lead the charge in overseeing a national Audit & Compliance team, ensuring regulatory adherence, risk management, and operational excellence while driving process improvements and fostering cross-func...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$90K - $100K *

Join a team that's redefining the Fine & Decorative Arts landscape. Drive strategic growth by transforming buyer demand into actionable supply opportunities, enhancing seller partnerships, and optimiz...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$72K - $110K *

Lead the charge in managing a diverse portfolio of network organizations, fostering relationships, and implementing strategic capacity-building initiatives to enhance organizational performance and su...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Champion the delivery of civil works and architectural projects, overseeing contractors and ensuring high-quality execution from site prep to completion. Leverage your expertise to manage complex site...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $128K *

Analyze and monitor security alerts, investigate threats, and enhance SOC processes. Collaborate with teams to ensure cybersecurity measures are effective, while documenting incidents and providing te...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$75K - $142K *

Lead a team of specialists in managing absence and claim cases, ensuring operational excellence and high-quality service delivery while fostering a supportive and growth-oriented environment for team...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Unlock potential by leading our marketplace operations, connecting first responders with experienced coaches. Drive efficiency, manage cross-functional teams, and ensure seamless service delivery whil...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$123K - $157K *

Advance your career by leading strategic sourcing for metals, driving cost savings and supplier performance. Engage with cross-functional teams to influence decisions and ensure supply continuity whil...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$123K - $157K *

Lead the charge in global sourcing strategies for plastics, driving supplier relationships and cost optimization while ensuring supply continuity and supporting new product introductions across manufa...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$184K - $254K *

Shape the future of Procurement by leading enterprise capabilities that enhance performance, streamline processes, and drive technology integration, ensuring measurable value and strategic alignment a...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$104K - $143K *

Champion the alignment of business requirements with implementation teams, ensuring documentation is clear and actionable. Drive the evolution of NBA standards and practices while managing configurati...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$138K - $191K *

Join a team that's redefining healthcare innovation by translating ideas into impactful solutions. Collaborate with senior executives to drive strategic initiatives and enhance population health throu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$129K - $177K *

Champion the development of intelligent decision systems using machine learning and reinforcement learning to enhance personalized healthcare recommendations, driving impactful outcomes for millions o...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$115K - $158K *

Join us to shape the future of member experiences in healthcare by leading innovative design projects, collaborating with cross-functional teams, and enhancing service delivery through user-centered d...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$126K - $173K *

Develop and enhance a data-driven decisioning platform, collaborating with cross-functional teams to optimize personalized member experiences while balancing immediate needs with long-term strategic g...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$104K - $143K *

Empower healthcare transformation by developing strategic initiatives that enhance operational efficiency and clinician productivity. Collaborate cross-functionally to drive impactful solutions and im...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$126K - $173K *

Shape the future of enterprise decisioning by leading cross-functional product initiatives that enhance customer experiences and drive operational readiness across multiple business channels...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Lead the charge in developing and executing business strategies to acquire new clients, expand market reach, and drive sustainable revenue growth through consultative selling and strategic relationshi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.