Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$120K - $150K *

Lead the charge in building long-term customer relationships while optimizing operations. As a Business Manager, you'll drive strategic growth, manage key accounts, and collaborate across teams to enh...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$160K - $200K *

Lead transformative partnerships in the travel industry, driving strategic growth and revenue. Engage with C-suite executives to secure high-impact deals and elevate market positioning through collabo...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$90K - $110K *

Empower individuals by providing comprehensive health care services in diverse settings. Utilize your expertise to diagnose, manage illnesses, and promote wellness through education and counseling, en...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Transform product operations by enhancing collaboration across teams and streamlining the launch processes. Utilize data-driven insights and AI to identify bottlenecks and drive efficiency, ensuring s...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$106K - $176K *

Join a team that's transforming healthcare finance by leading patient financial services operations. Drive revenue cycle improvements, manage billing processes, and enhance compliance while fostering...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Business Services

$110K - $125K *

Engage with a dynamic team to oversee copy responsibilities, crafting compelling content across various mediums. Collaborate creatively to drive engagement for diverse audiences, including healthcare...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Take ownership of driving sales success while mentoring and training new agents. You'll master our sales system and lead a team to achieve high performance, ensuring both personal sales and team growt...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$75K - $100K *

Champion growth by engaging clients and driving sales in life insurance. Take ownership of your career with unlimited income potential and comprehensive training. Join a dynamic team focused on result...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Empower your career by joining a dynamic team as a Field Support Engineer, where you'll tackle complex technical challenges in mission-critical environments, leveraging your expertise in Red Hat OpenS...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Elevate your career by contributing to critical security initiatives, leveraging your expertise in incident response, cryptographic modernization, and technical policy formulation to enhance enterpris...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$175K *

Engage with high-net-worth clients, converting prospects to loyal partners. Leverage provided leads and support to educate about wealth management solutions while developing your sales expertise in a...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$83K - $104K *

Join a team that's driving strategic marketing initiatives and influencing success. Collaborate with leaders to develop compelling narratives and innovative strategies that elevate project pursuits an...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$100K - $110K *

Drive valuable insights by enhancing Anaplan models and dashboards, collaborating with teams to implement solutions and improve functionality, while supporting users throughout the development lifecyc...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$71K - $124K *

Champion sales growth by managing CPA firm accounts, implementing strategies, and driving product engagement. Collaborate with teams to enhance client relationships and contribute to product developme...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$120K - $160K *

Join a team to lead commissioning projects, providing technical expertise and project management for critical facilities. Collaborate across teams, mentor others, and ensure successful testing and val...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Technical Services

$385K - $400K *

Transform regional sales performance by leading a high-impact team, driving strategic growth, and utilizing best practices to meet ambitious quotas within a dynamic environment. Foster relationships a...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$212K - $287K *

Transform the Hematology landscape by leading a high-performing sales team, driving strategic initiatives, and ensuring compliance while exceeding sales objectives in the Great Plains region...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$184K - $356K *

Drive technical engagement with telecom accounts, connecting customer workloads to NVIDIA's ecosystem. Serve as a trusted advisor, co-design scalable architectures, and lead technical enablement to en...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$145K - $170K *

Join us to drive strategic sales initiatives, leveraging a robust resource model and tech stack to achieve performance goals and maximize customer value in a dynamic, collaborative environment...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $90K *

Transform the claims landscape by managing commercial property claims, collaborating with diverse teams, and enhancing your expertise in global and excess lines. Join a dynamic environment focused on...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Empower the CDL program by leading training initiatives, ensuring compliance, and optimizing fleet management. Collaborate with regional leaders to enhance operational efficiency and drive revenue gro...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$135K - $160K *

Lead the charge in developing and executing CMC strategies for antibody-based radiopharmaceuticals, ensuring alignment with Stage-Gate requirements while managing cross-functional teams and external p...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$124K - $135K *

Shape impactful training programs for Field Access teams, enhancing access and reimbursement capabilities across therapeutic areas. Collaborate with stakeholders to ensure compliance and relevance, fo...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$112K - $189K *

Lead the charge in delivering exceptional pharmaceutical care by interpreting prescriptions, consulting with patients, and ensuring quality assurance. Collaborate with healthcare professionals to opti...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Empower developers by diagnosing and resolving complex technical issues related to APIs. Collaborate across teams, advocate for improvements, and enhance developer experiences in a fast-paced, innovat...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.