Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$85K - $110K *

Lead and oversee a dynamic Biomedical team, managing projects, costs, and quality across facilities. Drive performance, compliance, and professional development while ensuring optimal staffing and ope...

Gulfport, MSRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$68K - $105K *

Transform your career by configuring and supporting Epic applications. Engage in systems analysis, design, and problem resolution while collaborating with end-users to enhance their experience and str...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Join a team that shapes global regulatory strategy in a fast-paced environment. You will lead comprehensive regulatory plans, ensuring alignment and execution from development to post-marketing, impac...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Manage daily pharmacy operations, ensuring optimal patient care and compliance. Lead staff training, develop policies, and enhance service quality while monitoring performance and resource allocation...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Join a team that's focused on driving partner growth in the travel industry. Leverage your expertise to build relationships, implement strategic plans, and engage clients, all while thriving in a coll...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$84K *

Join a team that's dedicated to maintaining and optimizing electrical and instrumentation systems. This role involves hands-on troubleshooting, repair, and preventive maintenance in an industrial envi...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$88K - $105K *

Drive operational excellence by owning the Professional Services intake and workflow governance processes, ensuring efficient request management and seamless team collaboration to enhance service deli...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Shape the future of talent acquisition by managing end-to-end recruitment processes, collaborating with cross-functional teams, and optimizing hiring strategies to attract top talent in a fast-paced e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Transportation

$100K - $120K *

Engage with government agencies to drive revenue through strategic partnerships. Cultivate relationships, identify opportunities, and execute sales strategies to meet growth objectives in the Intellig...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Transportation

$131K - $237K *

Unlock potential by driving business growth in the cruise missile sector, engaging with U.S. Navy and Marine Corps stakeholders to identify and capture new opportunities while collaborating with cross...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$185K - $344K *

Join a dynamic team driving strategic planning and performance management across analytics capabilities. Lead portfolio governance and execution initiatives to align resources and priorities, ensuring...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $113K *

Lead strategic initiatives to enhance advocacy for California's children and youth. Collaborate with stakeholders, manage programs, and drive fundraising efforts to ensure impactful policy changes and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $110K *

Drive end-to-end payroll processes across multiple entities, ensuring accuracy and compliance. Manage domestic and international payroll, tax setups, and employee inquiries while building scalable sys...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$81K - $136K *

Join a team that's pioneering innovative radar and surveillance solutions. Lead proposal management and program execution, ensuring high-quality submissions while collaborating across functions to dri...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Lead the charge in managing a technical team focused on Gitaly, driving performance, scalability, and maintainability while fostering a culture of accountability and ownership across distributed teams...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$148K - $313K *

Unlock potential by serving as a strategic advisor to enterprise clients, guiding them in architecting AI-first solutions within the Life Sciences sector, while driving internal initiatives and enhanc...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's redefining application security by guiding customers through complex evaluations. Leverage your expertise in offensive security to build relationships, deliver impactful demos, and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Drive growth by building and expanding enterprise pipelines through strategic outbound efforts and executive networking. Collaborate cross-functionally to secure high-value deals and establish long-te...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Lead the charge in providing comprehensive psychiatric care to individuals and families. Utilize your expertise to assess, diagnose, and treat mental health conditions while collaborating with medical...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$125K - $150K *

Unlock potential by architecting innovative IT solutions that align with client goals. Collaborate with sales teams and engage directly with customers to deliver tailored strategies, ensuring successf...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$73K - $132K *

Join a dynamic team as a Senior Environmental Chemist, providing expert oversight in environmental data management and validation. Lead projects ensuring compliance and quality in remediation efforts...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Technical Services

$144K - $230K *

Engage with our sales team as a Technical Sales Lead, driving technology evaluations and managing customer relationships. Leverage your expertise in telecommunications to ensure satisfaction throughou...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$110K - $159K *

Empower the Clinical Documentation Integrity team by ensuring staff competency through quality assurance, training, and performance management. Collaborate on action plans and foster associate develop...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$225K - $418K *

Champion advanced analytics to enhance patient outcomes through data-driven insights. Lead a team in analyzing healthcare data, fostering strategic partnerships, and communicating complex findings to...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$152K - $283K *

Accelerate analytics governance and operations by leading initiatives that enhance decision-making processes, streamline reporting, and modernize workflows across teams, ensuring effective collaborati...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.