Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$100K - $130K *

Transform healthcare by leading a dynamic PMO, ensuring program transparency and compliance across multiple customer accounts while fostering collaboration and continuous improvement...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$75K - $90K *

Unlock new business opportunities by developing strategic marketing and sales plans. Collaborate with executives to secure and grow employer accounts, driving revenue growth and expanding market share...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Join a team that's transforming healthcare by driving enterprise sales and partnerships with leading health systems. Leverage your expertise to educate executives on innovative solutions that enhance...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $100K *

Develop strategic customer relationships and expand international presence by acquiring new enterprise clients and nurturing existing accounts in the pharmaceutical and life sciences sectors...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$88K - $120K *

Explore innovative marketing automation solutions by collaborating with teams to implement Salesforce Marketing Cloud technologies, ensuring high-quality execution and strategic alignment for client c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$165K - $185K *

Unlock your potential by leading the design and implementation of innovative digital solutions for Veteran healthcare services. Collaborate with cross-functional teams to enhance enterprise applicatio...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$166K - $200K *

Engage with strategic accounts to drive sales growth and build influential relationships. Leverage deep industry knowledge to create tailored solutions, manage complex negotiations, and achieve perfor...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$100K - $120K *

Elevate project outcomes by leading cross-functional teams to deliver clinical research projects on time and within budget, ensuring compliance with regulatory standards and client expectations while...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$126K - $172K *

Transform customer experiences by providing expert technical support, troubleshooting issues, and implementing scalable solutions. Collaborate with global teams to enhance service delivery and ensure...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $190K *

Shape the future of our legal operations by leading in-house legal efforts, managing contracts, advising on compliance, and collaborating with leadership to drive strategic initiatives across commerci...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $159K *

Analyze and build evaluation frameworks for AI agents, ensuring quality and performance meet client and business standards. Collaborate with cross-functional teams to establish testing methodologies a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$75K - $90K *

Unlock potential by exploring various technology disciplines at the Designer I level. Collaborate with mentors, gain hands-on experience, and apply fundamental skills across ICT, Security, AV, and mor...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$69K - $101K *

Grow your career with a dynamic team providing holistic clinical care management services. Collaborate with diverse populations to enhance health outcomes through assessment, care planning, and coordi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$126K - $170K *

Elevate your career by driving risk selection and profitability in a dynamic Excess Liability Division. Collaborate with clients and internal teams to deliver tailored insurance solutions while mainta...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$228K - $285K *

Pioneer advancements in AI inference platforms, driving strategy and execution across cross-functional teams to enhance scalability and reliability for enterprise customers. Lead product initiatives f...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$144K - $200K *

Shape the future of enterprise technology by leading transformative consulting engagements. Collaborate with C-level executives to drive strategic initiatives in AI, cloud, and analytics, ensuring imp...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$80K - $95K *

Drive growth by acquiring new customers for our innovative SaaS solutions. Leverage your sales expertise to engage decision-makers, understand their needs, and promote our Amplify Platform, focusing o...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Unlock potential by driving growth in our Enterprise Content Management business. Engage with diverse stakeholders, navigate complex sales cycles, and expand client relationships across the Midwest wh...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$115K - $130K *

Drive financial success by overseeing BIM project operations, managing budgets, and collaborating with stakeholders to ensure alignment with organizational objectives while delivering comprehensive fi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $245K *

Unlock your potential as a Senior Sales Account Executive, driving strategic sales initiatives across diverse industries. Engage with C-level executives, manage complex sales cycles, and leverage inno...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Manage key capital markets activities, overseeing debt operations, cash flow forecasting, and financial risk management. Collaborate with stakeholders to prepare executive materials and support pensio...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$86K - $110K *

Take ownership of digital marketing operations, managing CRM campaigns and creative processes. Collaborate across teams to enhance performance, streamline workflows, and leverage AI for improved resul...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $200K *

Transform compliance within a dynamic enterprise by designing and overseeing an effective Ethics and Compliance Program that aligns with regulations and promotes enterprise growth. Drive culture and a...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Business Services

$140K - $160K *

Unlock potential by driving the evolution of AWS environments and CI/CD pipelines, enhancing observability and security, while collaborating with engineers to optimize platform reliability and perform...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $120K *

Lead the charge in regulatory affairs by providing strategic guidance, ensuring compliance, and fostering collaboration across institutions. Drive initiatives from research to implementation while men...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.