Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$80K - $95K *

Grow your career with a dynamic role managing end-to-end event strategies, logistics, and sales partnerships. Drive impactful industry conferences and user events that significantly contribute to pipe...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $125K *

Join a team that's dedicated to delivering expert tax solutions while ensuring compliance and fostering client relationships. Leverage your extensive experience in tax preparation and planning to driv...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$180K - $210K *

Accelerate progress at the forefront of AI integration, designing secure enterprise architectures that enhance healthcare services for Veterans. Lead initiatives across cloud and on-premise platforms...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$158K - $197K *

Transform real-world health data into actionable insights by leveraging advanced bioinformatics and AI techniques. Lead innovative analyses in oncology and genomics, facilitating cross-functional coll...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $100K *

Shape the future of medical communications by crafting high-quality, scientifically accurate content. Collaborate with diverse teams to deliver impactful resources that meet client needs while mentori...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$124K - $207K *

Transform global benefits strategies by leading a dynamic team, ensuring compliance, and enhancing employee wellbeing. Drive innovative solutions while managing vendor relationships and collaborating...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $159K *

Lead the charge in transforming audience intelligence through innovative product strategies, enhancing consumer insights and data-driven solutions for brands and partners while ensuring privacy and co...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $159K *

Drive product health standards by defining metrics and telemetry for all products. Collaborate with cross-functional teams to ensure consistent data definitions and empower teams with self-serve dashb...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Advance payer integrations by managing complex processes and relationships. Drive outreach and research to establish direct connectivity with 3,000+ payers, ensuring accurate data and efficient handof...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$54K - $159K *

Champion contract negotiations by driving initiatives, cultivating relationships, and ensuring compliance with performance goals. Leverage expertise to support cost-saving strategies and enhance cross...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $160K *

Manage labor and employment legal matters, ensuring compliance and providing strategic counsel. Collaborate with HR and stakeholders to develop solutions, supervise outside counsel, and educate on pol...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$120K - $145K *

Drive mobile engineering excellence by leading app development, mentoring engineers, and integrating AI solutions to enhance user experiences across iOS and Android platforms while collaborating with...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$80K - $95K *

Join a dynamic team as a strategic HR partner, driving organizational success through effective talent management, employee engagement, and operational support. Collaborate with leaders to align HR in...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$100K - $150K *

Accelerate progress at a dynamic SaaS company by driving revenue growth through strategic sales cycles. Leverage your expertise in complex enterprise solutions to build relationships and exceed target...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $115K *

Empower patient health by managing care in a dynamic pediatric critical care unit. Collaborate with physicians to assess, diagnose, and implement comprehensive care plans while mentoring nursing staff...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$155K - $259K *

Shape the future of our captive and reinsurance business by leading actuarial strategies, optimizing structures, and delivering insights that drive profitable growth through collaboration and analytic...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$110K - $130K *

Drive growth and expand market presence by managing territory sales, developing customer relationships, and collaborating cross-functionally to achieve strategic objectives in the Motion Control secto...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$186K - $218K *

Champion the development of critical cryptographic infrastructure, leading high-availability services and innovative solutions while collaborating with cross-functional teams to ensure secure executio...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Transform asset management processes by developing and enhancing Oracle EBS modules, ensuring seamless integration and automation for improved efficiency and compliance in financial operations...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Join a team that's driving sales growth in the home improvement sector. This role focuses on developing dealer partnerships, expanding market presence, and achieving sales objectives through strategic...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$78K - $130K *

Drive financial accuracy and transparency by managing external reporting, technical accounting, and equity accounting. Collaborate with cross-functional teams to ensure compliance with U.S. GAAP and S...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$99K - $110K *

Lead the preparation and delivery of tax returns for ultra-high-net-worth clients. Enjoy a supportive environment with no billable hours, focusing on client service and tax compliance while benefiting...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$240K - $330K *

Transform security operations by leading a dynamic Product Security team. Drive risk-based strategies, empower engineering teams, and enhance security posture through automation and collaboration. Sha...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Contribute to impactful consulting services in government pricing, leveraging your expertise to guide clients through compliance, data analysis, and strategic initiatives while leading a collaborative...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$130K - $155K *

Drive innovation by developing AI-driven software solutions that enhance secure application delivery. Collaborate with cross-functional teams to tackle complex challenges and shape the future of softw...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.