Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$130K - $155K *

Unlock your potential by owning the technical design of a comprehensive data platform. Collaborate with cross-functional teams to deliver trustworthy data solutions that enhance product performance an...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$110K - $140K *

Champion the design and execution of eCOA studies, ensuring compliance and data integrity. Collaborate with cross-functional teams to deliver high-quality clinical outcomes while managing multiple pro...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Join a team that's dedicated to providing expert clinical support in radiation oncology. Oversee the radiation physics program, ensuring accurate treatment plans, compliance with safety standards, and...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$201K - $251K *

Champion Quality governance by leading the development and management of Quality Agreements across global operations, ensuring compliance and effective partnerships with internal and external stakehol...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$62K - $125K *

Transform the sales landscape by building your own pipeline through relentless prospecting and effective demos. Collaborate with leadership to refine strategies and drive growth in a dynamic startup e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$70K - $118K *

Join a dynamic team to deliver impactful data analysis and reporting solutions, enhancing operational efficiency and decision-making through the Microsoft Power Platform and hands-on analytical suppor...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$100K - $120K *

Empower your career by cultivating client relationships and driving sales growth. This role focuses on renewing software subscriptions and upselling products, leveraging strategic insights to enhance...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$130K - $160K *

Partner with us to showcase cutting-edge workforce management solutions, leveraging your pre-sales expertise and presentation skills to drive value for prospective clients in a dynamic, fast-paced env...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$46K - $122K *

Join a team that's redefining healthcare contracts by leveraging financial expertise and strategic negotiation skills to enhance client relationships and drive business success in a dynamic environmen...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Lead cross-functional projects in health plan relations, enhancing revenue cycle performance and outcomes. Utilize strong communication and project management skills to coordinate initiatives, track p...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Engage in strategic leadership to enhance wholesale market placements, ensuring optimal coverage and pricing. Oversee national partnerships and market execution while driving team performance and resp...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$80K - $95K *

Analyze and evaluate AI-generated chatbot responses to enhance accuracy and relevance. Collaborate with stakeholders to document requirements and deliver structured assessments that drive improvements...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Staffing

$160K *

Drive enterprise-level implementations of phishing-resistant authentication solutions, leading technical deployments and integrations across various identity platforms while ensuring customer success...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $180K *

Lead strategic health plan implementations and optimize client solutions. Drive cross-functional collaboration, manage complex projects, and enhance operational workflows to ensure successful launches...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $120K *

Shape your career as you take ownership of key accounts, driving sales and building relationships. Collaborate with top performers to modernize government services, while gaining invaluable experience...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Drive business growth by assessing market opportunities, developing strategies, and delivering compelling presentations. Collaborate with teams to align marketing efforts and support client proposals...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$105K - $150K *

Inspire impactful change by leading complex federal digital services programs. Oversee strategy, execution, and customer relationships while managing multidisciplinary teams to deliver high-quality te...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Lead the product vision and strategy for a cutting-edge cloud service, shaping capabilities and defining AI-driven insights while collaborating with engineering and operations teams to ensure market a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $110K *

Join a team that's shaping evidence strategies and insights in health economics and outcomes research. Lead client engagements, oversee analytics, and drive impactful decision-making in biopharma and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$115K - $120K *

Contribute to client well-being by providing virtual therapy sessions for individuals, couples, and families. Manage case documentation and coordinate additional support as needed while maintaining co...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Join a team that's shaping the future of software development by leading projects, mentoring engineers, and architecting innovative solutions that enhance performance and meet business goals in a coll...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$170K - $205K *

Unlock the potential of our Pro offering by leading product strategy and roadmap. Collaborate across teams to enhance customer experiences for short-term rental operators and HOAs, ensuring scalable s...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$138K - $214K *

Optimize project outcomes by leading preconstruction efforts for large-scale Data Center initiatives. Drive team performance, manage budgets, and ensure exceptional client relationships while overseei...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Champion client success by managing key relationships and driving strategic initiatives. Lead cross-functional teams to deliver high-quality work while ensuring financial performance and growth for as...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Advance your career by building high-throughput services that power AI workflows. Collaborate with cross-functional teams to design scalable infrastructure and tackle complex challenges in a dynamic e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.