Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$80K - $95K *

Transform inpatient coding operations by leading a dedicated team to ensure accurate coding, compliance, and timely billing. Collaborate with clinical and administrative staff to enhance financial per...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$100K - $108K *

Unlock growth by developing product strategies that enhance customer value and drive sales. Collaborate with cross-functional teams to manage product launches, marketing support, and training, ensurin...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

$116K - $155K *

Join a dynamic team as you design and optimize Oracle EBS integrations, enhancing supply chain solutions. Utilize your expertise to drive impactful software engineering efforts that elevate business p...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$125K - $165K *

Lead advanced power system studies while mentoring engineers and driving innovative solutions for grid modernization and renewable energy integration. Collaborate with teams to ensure accuracy and hig...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$160K - $180K *

Drive financial excellence by overseeing accounting, compliance, and internal controls. Collaborate with agency leadership to enhance processes, ensure accuracy, and maintain balance sheet integrity w...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Media

$95K - $115K *

Unlock potential by leveraging data science to drive informed decision-making through advanced analytics, modeling, and collaboration in a dynamic research environment...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$88K - $105K *

Lead estimating efforts by developing precise project estimates, analyzing impacts, and guiding teams. Leverage expertise in construction methods and cost structures to support project pursuits and dr...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$138K - $165K *

Champion the future of quantum computing by defining product vision and driving development for innovative solutions. Collaborate with cross-functional teams to integrate quantum capabilities into SAS...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$84K - $129K *

Drive innovative structural engineering solutions for nuclear facilities, collaborating with multidisciplinary teams to enhance safety and efficiency. Guide junior engineers while leveraging advanced...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$77K - $118K *

Elevate your career by designing high voltage substations, collaborating with engineers to create detailed drawings and plans. Utilize your expertise in AutoCAD or MicroStation to deliver high-quality...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$85K - $130K *

Drive the design and modification of power plant electrical systems, collaborating with multi-disciplined teams to create detailed diagrams and wiring drawings. Engage in field data gathering and ensu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$114K - $200K *

Champion growth by leading the Enterprise Sales team, driving member acquisition, and executing strategic sales initiatives in the cybersecurity sector. Collaborate with stakeholders to enhance sales...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $160K *

Transform project scheduling by leading high-visibility initiatives, ensuring compliance with CPM best practices, and mentoring teams to exceed client expectations while managing complex resource allo...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$100K - $145K *

Elevate organizational performance by facilitating hands-on training for construction teams, enhancing skills in safety, quality, and standard processes while championing corporate culture and continu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$162K - $195K *

Shape the future of cardiovascular care by driving the launch of a novel cardiac myosin inhibitor. Collaborate with healthcare professionals and internal teams to establish strategic relationships and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$162K - $195K *

Drive sales performance by launching a novel cardiac myosin inhibitor, building strategic relationships with healthcare providers, and delivering impactful solutions to meet patient needs in your terr...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$162K - $195K *

Lead the launch of a novel cardiac myosin inhibitor in your territory, driving sales and building strategic relationships with healthcare providers. Collaborate with internal teams to meet patient nee...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$121K - $156K *

Join a team that's shaping urban transportation infrastructure by leading innovative rail and transit projects. Collaborate across disciplines to deliver high-quality designs and manage client relatio...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$90K - $105K *

Drive the migration of patient data within a healthcare IT modernization program. Oversee planning, execution, and reporting for your workstream, ensuring alignment with stakeholders and delivery of h...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$160K - $210K *

Lead the charge in transforming Cyber Governance, Risk & Compliance through innovative data, AI, and automation strategies. Drive measurable outcomes and modernize technology platforms while building...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$90K - $110K *

Optimize patient care by leading the rehabilitation department, ensuring compliance and financial performance while fostering teamwork and excellence in service delivery across multiple sites...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Optimize partner relationships by managing implementations and operations for new agreements. Drive success through effective communication, performance monitoring, and strategic growth initiatives, e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$135K - $150K *

Join a team that's redefining business intelligence through Power BI. You'll develop impactful reports and dashboards, enhance client-facing platforms, and ensure data integrity while collaborating wi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$154K - $216K *

Champion community engagement by designing and executing lifecycle programs that educate and empower moderators through strategic, multichannel campaigns, ensuring seamless communication and community...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Media

$100K - $115K *

Optimize revenue accounting and billing operations for a rapidly growing SaaS organization. Collaborate with leadership on process improvements, ASC 606 compliance, and support integration initiatives...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.