Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
Average Salary: $111,580
Senior Software Security Architect
$135K - $160K *
Advance security integration by leading DevSecOps initiatives, enhancing software delivery, and establishing robust security standards across engineering teams to mitigate risks and improve efficiency...
1 week ago
$68K - $113K *
Lead project coordination efforts by ensuring effective communication and management of materials, schedules, and documentation. Collaborate with teams to streamline processes and enhance project effi...
Reposted 1 week ago
Regional Product Manager (Protein Diagnostics)
$103K - $154K *
Lead the commercial success of a diverse product portfolio across North America. Drive growth, customer adoption, and lifecycle management while collaborating with cross-functional teams to align stra...
1 week ago
Regulatory Affairs Consultant, CMC - Biologics
$110K - $130K *
Drive your career with a pivotal role in CMC regulatory affairs, ensuring compliance for biologics and small molecules. Collaborate across teams to prepare high-quality submissions and strategies, imp...
1 week ago
Manager, Ecosystem Partnerships
$104K - $174K *
Champion ecosystem growth by collaborating across teams to enhance partner operations, drive strategic initiatives, and optimize performance metrics, ensuring value delivery to customers and stakehold...
Reposted 1 week ago
$95K - $115K *
Join a team that's driving integration data migration strategies and analysis. Collaborate with project teams to execute and support data governance initiatives, ensuring quality and efficiency across...
1 week ago
Director, Clinical Supply Chain (or Senior)
$210K - $230K *
Accelerate progress at the forefront of clinical supply chain management, leading strategic initiatives to ensure seamless delivery of investigational products for global trials while collaborating ac...
1 week ago
$73K - $102K *
Champion ERP solutions by collaborating with stakeholders to customize and integrate systems, ensuring alignment with business goals. Drive enhancements and maintain compliance while delivering effect...
1 week ago
$81K - $137K *
Unlock financial insights by leading complex accounting operations, ensuring accuracy in reporting, and collaborating with cross-functional teams to enhance processes and drive business decisions in a...
1 week ago
$160K - $190K *
Unlock your potential as you lead end-to-end design for complex AI-driven systems. Collaborate with cross-functional teams to create intuitive, secure user experiences that prioritize trust and precis...
1 week ago
$184K - $356K *
Innovate at the forefront of AI infrastructure validation by designing and implementing robust tooling for cluster readiness and certification, ensuring optimal performance for GPU deployments in prod...
1 week ago
Business Development Associate
$70K - $96K *
Empower your career by joining our dynamic team to drive client engagement, identify opportunities, and develop innovative sales strategies. Collaborate with stakeholders and enhance your skills in a...
1 week ago
Healthcare Program & Project Manager (Remote)
$80K - $95K *
Transform healthcare initiatives by leading projects from inception to completion. Coordinate teams, manage timelines, and ensure clear communication to drive organizational priorities and deliver mea...
1 week ago
$170K - $195K *
Lead the charge in powering global initiatives by overseeing operations support, ensuring compliance, and implementing best practices across a vast energy portfolio to drive performance and safety in...
Reposted 1 week ago
Senior Solutions Engineer, Acquisition | West Coast | Remote
$204K - $254K *
Drive customer success by leveraging technical expertise to engage, educate, and empower clients. Collaborate with sales to articulate value propositions and enhance product offerings in a dynamic, re...
1 week ago
Senior Customer Technical Specialist
$110K - $130K *
Drive customer success by leveraging technical expertise to enhance product adoption and value. Engage with enterprise clients, ensuring alignment with their business goals while shaping product evolu...
1 week ago
Engineering Manager, Integrations
$187K - $234K *
Empower the Integrations team to scale impact by leading third-party integrations, creating reusable capabilities, and fostering a collaborative culture that drives effective delivery and continuous i...
1 week ago
Architectural Service Consultant - Project Manager (National Multi-Family)
$90K - $156K *
Transform the multifamily project landscape by serving as the key client liaison, managing project lifecycles, and ensuring quality standards are met from design to construction. Drive success through...
1 week ago
$175K - $195K *
Lead the charge in shaping enterprise data architecture, ensuring scalable, secure access across systems. Collaborate with engineering teams to deliver impactful data solutions that drive business val...
1 week ago
Assistant Professor- Pediatric Rheumatology - Department of Pediatrics
$100K - $120K *
Shape the future of pediatric rheumatology by educating future leaders, conducting impactful research, and providing exceptional patient care in a collaborative academic environment dedicated to healt...
1 week ago
$80K - $95K *
Manage multiple Corporate Performance Management projects, providing strategic guidance and ensuring timely deliverables. Utilize strong communication and organizational skills to coordinate tasks and...
1 week ago
Backend Software Engineer II- Data Platform
$120K - $130K *
Join a team that's building a robust data platform to transform health data into actionable insights. Collaborate on backend services and data systems, enhancing reliability and performance while driv...
Reposted 1 week ago
Senior Director, Head of Oncology
$228K - $342K *
Elevate oncology project management by leading a high-performing team, ensuring operational excellence, and driving global programs through the development lifecycle while fostering strategic partners...
1 week ago
Senior Product Analytics Manager
$175K - $185K *
Optimize product performance through data-driven insights, collaborating with cross-functional teams to define metrics, analyze customer behavior, and support strategic planning for impactful product...
1 week ago
$175K - $185K *
Unlock potential by leading global product strategies that drive growth and innovation. Collaborate cross-functionally to prioritize customer needs, enhance product performance, and support internatio...
1 week ago
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.