Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$135K - $160K *

Advance security integration by leading DevSecOps initiatives, enhancing software delivery, and establishing robust security standards across engineering teams to mitigate risks and improve efficiency...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$68K - $113K *

Lead project coordination efforts by ensuring effective communication and management of materials, schedules, and documentation. Collaborate with teams to streamline processes and enhance project effi...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$103K - $154K *

Lead the commercial success of a diverse product portfolio across North America. Drive growth, customer adoption, and lifecycle management while collaborating with cross-functional teams to align stra...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive your career with a pivotal role in CMC regulatory affairs, ensuring compliance for biologics and small molecules. Collaborate across teams to prepare high-quality submissions and strategies, imp...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$104K - $174K *

Champion ecosystem growth by collaborating across teams to enhance partner operations, drive strategic initiatives, and optimize performance metrics, ensuring value delivery to customers and stakehold...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$95K - $115K *

Join a team that's driving integration data migration strategies and analysis. Collaborate with project teams to execute and support data governance initiatives, ensuring quality and efficiency across...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$210K - $230K *

Accelerate progress at the forefront of clinical supply chain management, leading strategic initiatives to ensure seamless delivery of investigational products for global trials while collaborating ac...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$73K - $102K *

Champion ERP solutions by collaborating with stakeholders to customize and integrate systems, ensuring alignment with business goals. Drive enhancements and maintain compliance while delivering effect...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$81K - $137K *

Unlock financial insights by leading complex accounting operations, ensuring accuracy in reporting, and collaborating with cross-functional teams to enhance processes and drive business decisions in a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$160K - $190K *

Unlock your potential as you lead end-to-end design for complex AI-driven systems. Collaborate with cross-functional teams to create intuitive, secure user experiences that prioritize trust and precis...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$184K - $356K *

Innovate at the forefront of AI infrastructure validation by designing and implementing robust tooling for cluster readiness and certification, ensuring optimal performance for GPU deployments in prod...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$70K - $96K *

Empower your career by joining our dynamic team to drive client engagement, identify opportunities, and develop innovative sales strategies. Collaborate with stakeholders and enhance your skills in a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Transform healthcare initiatives by leading projects from inception to completion. Coordinate teams, manage timelines, and ensure clear communication to drive organizational priorities and deliver mea...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $195K *

Lead the charge in powering global initiatives by overseeing operations support, ensuring compliance, and implementing best practices across a vast energy portfolio to drive performance and safety in...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$204K - $254K *

Drive customer success by leveraging technical expertise to engage, educate, and empower clients. Collaborate with sales to articulate value propositions and enhance product offerings in a dynamic, re...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Drive customer success by leveraging technical expertise to enhance product adoption and value. Engage with enterprise clients, ensuring alignment with their business goals while shaping product evolu...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$187K - $234K *

Empower the Integrations team to scale impact by leading third-party integrations, creating reusable capabilities, and fostering a collaborative culture that drives effective delivery and continuous i...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$90K - $156K *

Transform the multifamily project landscape by serving as the key client liaison, managing project lifecycles, and ensuring quality standards are met from design to construction. Drive success through...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$175K - $195K *

Lead the charge in shaping enterprise data architecture, ensuring scalable, secure access across systems. Collaborate with engineering teams to deliver impactful data solutions that drive business val...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Shape the future of pediatric rheumatology by educating future leaders, conducting impactful research, and providing exceptional patient care in a collaborative academic environment dedicated to healt...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Manage multiple Corporate Performance Management projects, providing strategic guidance and ensuring timely deliverables. Utilize strong communication and organizational skills to coordinate tasks and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $130K *

Join a team that's building a robust data platform to transform health data into actionable insights. Collaborate on backend services and data systems, enhancing reliability and performance while driv...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$228K - $342K *

Elevate oncology project management by leading a high-performing team, ensuring operational excellence, and driving global programs through the development lifecycle while fostering strategic partners...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K - $185K *

Optimize product performance through data-driven insights, collaborating with cross-functional teams to define metrics, analyze customer behavior, and support strategic planning for impactful product...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $185K *

Unlock potential by leading global product strategies that drive growth and innovation. Collaborate cross-functionally to prioritize customer needs, enhance product performance, and support internatio...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.