Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From positions in Jackson and the Gulf Coast to opportunities in communities across the state, find roles that match your experience, skills, and career goals.

Professional Opportunities Across Mississippi

Mississippi employers hire experienced professionals across industries such as healthcare, finance, manufacturing, technology, energy, and business operations. Available roles and compensation vary by employer, location, and qualifications, so review each listing for details about responsibilities, salary, and requirements.

Search in Mississippi Cities and Regions

Find opportunities in major employment centers including Jackson, Gulfport, and Southaven, as well as other Mississippi communities. Use location and job-title filters to focus your search, and consider remote or hybrid listings when available.

Find a Role That Fits Your Career

Compare opportunities by seniority, specialty, and work arrangement. Keep your résumé current, highlight measurable results, and tailor your application to the qualifications in each listing. Ladders helps professionals explore vetted jobs with salaries of at least $100,000.

Start Your Mississippi Job Search

Browse Mississippi jobs on Ladders and take the next step toward a professional opportunity aligned with your expertise and compensation goals. Listings change frequently, so check back for new roles.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,063

Sort By: Relevance

$120K - $140K *

Drive project success by leading cross-functional teams and managing multiple initiatives from inception to completion, ensuring alignment with client goals and quality standards while fostering stron...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Transform commissioning & startup projects by leading onsite teams, ensuring delivery on time and within budget while maintaining safety and quality standards. Collaborate with management and clients...

RemoteRemote

Reposted today

  •   8 - 10 years exp.  •   Real Estate & Construction

$108K - $162K *

Transform regional marketing efforts by executing targeted programs that align with sales priorities and drive pipeline growth across the U.S. West territory. Collaborate with cross-functional teams t...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Enterprise Technology

$235K - $310K *

Join a team that empowers translational medicine innovation in early-phase oncology, owning strategies from IND-enabling studies to proof of concept. Drive impactful biomarker integration and clinical...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$200K - $250K *

Champion supply chain strategy and execution for clinical operations, ensuring timely, compliant delivery of materials for global oncology trials. Collaborate with cross-functional teams to manage ris...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$165K - $195K *

Join a dynamic biotech team to drive strategic initiatives, manage cross-functional operations, and lead business development efforts. Leverage your scientific expertise and leadership skills to shape...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$165K - $200K *

Deliver exceptional user experiences by refining complex tools into intuitive designs. Collaborate closely with engineers to enhance UX, ensuring our LLM platform meets user needs with responsiveness...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Drive customer support excellence by managing a frontline team to ensure timely resolutions, operational efficiency, and a culture of continuous improvement, paving the way for stellar service in heal...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$86K - $149K *

Unlock your potential as a key technical leader, ensuring optimal performance of critical systems in a dynamic data center environment. Collaborate with teams to enhance operations, drive efficiency...

Today

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$114K - $191K *

Lead the charge in shaping high-impact SaaS solutions by driving technical strategy and empowering a high-performing engineering team. Collaborate across disciplines to foster innovation in a fast-pac...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$150K - $175K *

Lead community engagement initiatives to enhance patient advocacy for Becker Muscular Dystrophy. Collaborate with local organizations, educate patients, and build networks to ensure access to quality...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Join a dynamic team to deliver innovative design engineering solutions for power projects. Leverage your expertise in mechanical engineering to create impactful designs and ensure project success thro...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$100K - $125K *

Advance business growth by fostering relationships and crafting innovative strategies that drive revenue. Collaborate across teams to identify opportunities and enhance operational excellence while en...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Business Services

$105K - $255K *

The Senior Account Executive at Justworks is responsible for expanding the user base and driving significant growth by managing a complete end-to-end sales pipeline. This role requires a proven closer...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Business Services

$83K - $163K *

Accelerate your career by managing a full sales cycle, from prospecting to closing deals. Engage with the entrepreneurial community and drive revenue growth while building lasting relationships in you...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Business Services

$85K - $103K *

As an Account Executive in-territory in Miami, you will be responsible for managing the full sales cycle, including building and managing a sales pipeline, prospecting, and closing deals. This role re...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Business Services

$100K - $120K *

Partner with us to enhance relationships with executive partners, enabling pipeline growth and revenue generation. Leverage cross-functional collaboration while managing multiple engagements, driving...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Transform client engagement by driving growth in untapped markets, shaping impactful solutions, and delivering measurable results. Collaborate with diverse teams to connect client needs with innovativ...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Business Services

$107K - $195K *

Join a team that's shaping the future of microgrid automation and renewable energy. Leverage your expertise in control systems and collaborate on innovative projects that drive sustainable energy solu...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Technical Services

$150K - $238K *

Shape the future of digital manufacturing by leading strategic IT and operations initiatives. Drive multi-site transformation, ensuring seamless integration of technology and processes to enhance effi...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$155K - $160K *

Drive the Order-to-Cash strategy, overseeing cash application, collections, and AR performance. Collaborate cross-functionally to optimize cash flow and enhance financial reporting, ensuring timely re...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Join a dynamic team as you optimize recipe and task build solutions, driving operational excellence and standardization. Collaborate across departments to enhance workflows and implement scalable proc...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Technical Services

$80K - $95K *

Transform healthcare processes by leading quality improvement initiatives. Utilize lean, six sigma, and change management expertise to enhance operational excellence, patient satisfaction, and efficie...

Today

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Shape the future of water and wastewater systems by leading projects from planning to optimization. Collaborate with diverse teams to deliver innovative solutions for municipal and industrial clients...

United StatesRemote

Today

  •   15+ years exp.  •   Technical Services

$80K - $95K *

Drive project success by managing operational aspects and liaising with stakeholders. Oversee schedules, assess issues, and develop solutions to ensure timely objectives. Integrate data for risk manag...

Today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of jobs can I find in Mississippi on Ladders?question toggle

    You can explore professional opportunities across fields such as healthcare, finance, manufacturing, technology, energy, and business operations. Roles and availability vary over time.

  • Are Mississippi jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional jobs that pay $100,000 or more. Check each listing for compensation details, qualifications, and other job-specific information.

  • Where in Mississippi can I search for jobs?question toggle

    Search across the state, including employment centers such as Jackson, Gulfport, and Southaven. You can use location filters to narrow results.

  • How can I find remote or hybrid jobs based in Mississippi?question toggle

    Use available work-arrangement filters or review listing details to identify remote and hybrid opportunities. Availability depends on the employer and role.

  • How do I improve my chances of getting hired for a Mississippi job?question toggle

    Tailor your résumé to the role, emphasize relevant experience and measurable outcomes, and ensure you meet the listed qualifications before applying.