Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
Average Salary: $111,580
Senior Product Manager (Healthcare Data Products)
$120K - $145K *
Transform healthcare data products by leading strategy, execution, and cross-functional collaboration. Drive product-market fit and commercialization for API-based solutions, ensuring alignment with c...
1 week ago
Sales Manager - Australia/New Zealand Market
$100K - $120K *
Accelerate sales growth by leading strategies and initiatives across the ANZ market. Collaborate with a multidisciplinary team to drive customer engagement, develop market strategies, and achieve reve...
Reposted 1 week ago
$95K - $115K *
Transform procurement operations by leading strategy and team management in a regulated manufacturing environment. Drive supplier performance, cost efficiency, and material availability to support pro...
1 week ago
Software Engineer 4/5 - Model Serving Systems, AI Platform
$466K - $500K+*
Unlock potential by developing scalable AI/ML model serving infrastructure. Collaborate cross-functionally to enhance performance and availability of high-traffic systems, driving innovation in a dyna...
1 week ago
Director Strategy for Advanced Networking and Enterprise
$156K - $215K *
Empower innovation in advanced networking and enterprise solutions by defining strategic roadmaps and driving product lifecycle planning across high-speed networking, optical technologies, and AI plat...
1 week ago
Strategic Solution Sales Executive
$140K - $185K *
Drive strategic growth by identifying and developing solution-specific opportunities within key accounts, leveraging industry expertise to influence client transformation initiatives and enhance sales...
1 week ago
$150K - $180K *
Transform the Federal landscape by leading enterprise sales efforts, engaging with SES leaders, and driving digital transformation across major accounts. Collaborate with cross-functional teams to ach...
1 week ago
Diagnosis-Related Group (DRG) Auditor III
$73K - $98K *
Join a team that's dedicated to excellence in DRG auditing. Leverage your expertise in MS-DRG and APR-DRG coding to ensure accuracy and compliance while working remotely. Enjoy a collaborative environ...
1 week ago
IT Subject Matter Expert (SME)
$100K - $175K *
Transform operations by leveraging your expertise in IT and cybersecurity. Collaborate with leaders to enhance processes, drive efficiency, and ensure compliance while mentoring teams and aligning str...
Reposted 1 week ago
Staff Machine Learning Engineer, Ads Forecasting & Scenarios
$230K - $322K *
Lead the development of machine learning models to enhance advertiser insights, optimizing campaign performance through advanced forecasting and scenario analysis. Collaborate across teams to drive im...
1 week ago
Senior Software Engineer, Compute Platform
$165K - $225K *
Champion the development of a GPU-accelerated compute platform, enhancing AI training and research capabilities. Collaborate with cross-functional teams to design orchestration systems that optimize r...
1 week ago
Senior Strategic Marketing Manager | East Coast | Remote
$160K - $195K *
Join a team that's redefining account marketing for major clients. Collaborate with cross-functional partners to drive growth, enhance customer engagement, and create tailored marketing strategies tha...
1 week ago
$80K - $95K *
Innovate nursing practices by leading patient care initiatives, enhancing service delivery, and fostering collaboration across departments to improve satisfaction and operational efficiency in a dynam...
1 week ago
Regional Vice President, Central | Remote |
$450K - $475K *
Drive revenue growth by leading a team of Regional Directors, fostering collaboration, and ensuring alignment with company goals. Your leadership will shape the region's success and culture while enha...
1 week ago
Marketing Manager, Large Practice Services
$99K - $155K *
Drive impactful marketing initiatives by executing campaigns, managing operations, and collaborating with teams to enhance brand visibility and support sales growth. Leverage data insights to optimize...
1 week ago
$150K - $180K *
Transform the future of AI-driven infrastructure products by leading strategic growth initiatives, collaborating closely with Marketing and Engineering, and influencing key product decisions for optim...
Reposted 1 week ago
Principal Consultant - Senior SAP Account Manager
$150K - $180K *
Grow enterprise SAP relationships by managing key accounts and driving new business. Leverage your expertise to expand client portfolios, develop strategic plans, and ensure client satisfaction while...
1 week ago
$163K - $224K *
Drive strategic planning and execution of acquisitions/divestitures, ensuring seamless integration and value creation across teams. Collaborate cross-functionally to manage milestones, risks, and comm...
Reposted 1 week ago
Associate Vice President - Strategic Accounts & Client Success - Remote
$144K - $240K *
Transform healthcare delivery by leading strategic initiatives and optimizing infusion services. Drive client success through expert guidance, operational excellence, and innovative solutions, ensurin...
Reposted 1 week ago
AI Infrastructure Engineer [Senior]
$150K - $180K *
Transform AI infrastructure by designing and maintaining production-grade systems across multiple cloud providers. Engage in hands-on architecture decisions, ensuring reliability, security, and automa...
1 week ago
$120K - $145K *
Unlock potential by leading pre-sales technical strategies that align solutions with client needs, driving revenue growth and retention through collaboration with sales teams and delivering tailored p...
1 week ago
Senior SaaS Client Relationship Manager
$63K - $108K *
Lead enterprise accounts with 75+ locations, driving SaaS adoption and maximizing business value. Utilize industry expertise to resolve challenges, enhance client relationships, and support strategic...
1 week ago
Director, Marketing Investment + Effectiveness (Remote)
$189K - $235K *
Lead the marketing investment strategy, optimizing budget allocation between brand and performance. Collaborate with finance and executive teams to ensure effective spending and measurable returns, dr...
1 week ago
Controls Engineer - Field Service
$95K - $115K *
Transform control systems in the field as you analyze PLC code, troubleshoot equipment, and ensure regulatory compliance. Collaborate with internal teams and clients while traveling extensively across...
Reposted 1 week ago
$128K - $192K *
The Workday Financials Integrations Senior Principal Consultant - Global AMS is a seasoned professional responsible for leading integration efforts and managing Workday financial services for clients...
Reposted 1 week ago
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.