Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$110K - $130K *

Transform the member experience by owning the full lifecycle of features across a cutting-edge AI-first platform, leveraging technologies from React to GraphQL and AI services to deliver personalized...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

$100K - $120K *

Join a team that's driving growth in the commercial sector by leveraging data and AI solutions. As an Account Executive, you'll cultivate relationships, manage accounts, and optimize customer success...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$134K - $205K *

Drive civil and structural construction excellence by managing on-site activities, ensuring compliance with safety and quality standards, and collaborating with diverse teams to meet project milestone...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Technical Services

$160K - $180K *

Drive innovation as a Senior Product Manager, leading strategic initiatives in Adaptive Training and Continuous Learning. Collaborate with cross-functional teams to enhance user experiences and achiev...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $190K *

Lead project scheduling across a diverse portfolio, ensuring timely execution and risk mitigation. Collaborate with teams to develop critical path schedules, manage resources, and enhance project deli...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$115K - $175K *

Lead the charge in ensuring mission-critical projects meet quality standards through effective commissioning strategies, technical oversight, and stakeholder coordination. Drive operational readiness...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$180K - $225K *

Join a team that's driving operational excellence in platform management. As a key leader, you'll enhance mission readiness, enforce standards, and integrate cross-functional teams to ensure seamless...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$120K - $155K *

Join a team that's dedicated to enhancing national security through expert program analysis. Leverage your extensive experience to support critical FAA initiatives, ensuring compliance and effective p...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$164K - $228K *

Transform complex systems into a cohesive architecture by leading end-to-end solutions across CRM, billing, and integrations. Collaborate with stakeholders to address challenges and drive modernizatio...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $115K *

Drive high-quality technical support for aviation connectivity systems, ensuring customer satisfaction through troubleshooting, training, and collaboration with cross-functional teams in a fast-paced...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$93K - $134K *

Drive impactful data mining initiatives by analyzing complex claims across Medicare, Medicaid, and Commercial sectors. Leverage your expertise to identify anomalies and enhance recovery opportunities...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Optimize reimbursement strategies and regulatory compliance by leading analysis, developing policies, and mentoring teams. Drive operational excellence and foster relationships with stakeholders to en...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Unlock potential by leading technical vision and mentoring engineers. Drive modernization and collaboration across teams to build resilient, scalable infrastructure while fostering a high-performance...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$145K - $175K *

Lead commercial legal initiatives by providing strategic counsel, drafting agreements, and collaborating with cross-functional teams to drive business objectives while managing legal risks effectively...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Lead the charge in directing clinical rehabilitation operations across multiple practices, ensuring quality patient care and achieving financial and operational objectives through effective management...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $150K *

Drive growth by owning the self-serve revenue engine, optimizing user experiences, and leading experimentation to boost conversions. Collaborate across teams to enhance product adoption and revenue, p...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Media

$125K - $150K *

Join a team that's dedicated to providing exceptional dental care in a supportive environment. This role offers clinical autonomy, mentorship, and opportunities for professional growth while serving t...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Champion growth by developing and executing territory plans to maximize revenue. Collaborate with sales, marketing, and business development teams to drive results and enhance market share through eff...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Transform your career by leading the legal function for a pioneering foundation. You'll navigate complex IP, AI regulation, and nonprofit governance, ensuring compliance while fostering innovation and...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Accelerate progress at the forefront of clinical research by managing site operations, ensuring compliance, and fostering strong relationships throughout study phases. Your expertise will drive site p...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Lead the charge in transforming patient engagement by integrating booking into our core product. Drive innovative experiments and optimize multi-channel outreach to ensure underserved communities rece...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $143K *

Engage actively in assessing credit risk for commercial clients, ensuring compliance and sound lending practices while collaborating closely with relationship managers to facilitate decision-making an...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $145K *

Unlock potential by driving AI security marketing initiatives, creating demos, and collaborating with cross-functional teams to enhance product visibility and adoption. Serve as the technical voice fo...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$98K - $122K *

Empower progress at the intersection of project management and benefits innovation. Lead initiatives for 401(k) MEP and Benefits Billing, collaborating with diverse stakeholders to enhance operational...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Business Services

$95K - $158K *

Transform the Property Intelligence platform by connecting customer needs with product insights. Collaborate across teams to enhance product adoption and engagement through analytics and feedback, dri...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.