Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$72K - $107K *

Join a team that's dedicated to enhancing resident development through effective program management, collaboration with clinical leaders, and innovative professional development sessions to ensure a s...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$174K - $240K *

Champion innovative research in AI/digital safety, leading methodologies and partnerships to enhance assessment tools. Drive project management and team development to advance the mission of digital s...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$69K - $95K *

Lead and empower a dedicated clinical team to deliver high-quality home care. Oversee operations, ensure compliance, and enhance patient outcomes while fostering a supportive environment for clinician...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$117K - $161K *

Drive your career with this strategic role, leading Workday Compensation solutions. Collaborate with cross-functional teams to optimize compensation processes, ensuring alignment with business goals a...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$86K - $118K *

Join a team that's dedicated to enhancing consumer experiences through innovative solutions. Leverage your technical expertise in a collaborative environment focused on continuous improvement and impa...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$300K - $500K+*

Join a dynamic team as a senior leader driving portfolio performance across the eastern U.S. Oversee regional execution, manage a team of directors, and collaborate on national strategies to enhance b...

RemoteRemote

6 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$90K - $150K *

Unlock member value by managing pharmacy solutions, optimizing contract use, and fostering relationships with healthcare systems to enhance operational efficiency and savings...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $150K *

Join a dynamic team to leverage clinical expertise in healthcare consulting, driving improvements in perinatal care and women's health. Collaborate with leaders to analyze data, share best practices...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$72K - $120K *

Transform healthcare systems by analyzing data, leading client engagements, and implementing performance improvements. Collaborate with a skilled team to deliver actionable insights and drive meaningf...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead transformative Workday implementations, managing client relationships and project lifecycles. Drive innovation and strategic growth while ensuring exceptional customer satisfaction and effective...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$182K - $247K *

Drive innovative clinical operations to enhance member care and outcomes. Collaborate across teams to implement strategies, optimize processes, and scale programs, ensuring seamless coordination and e...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Accelerate your career by leading a dynamic team in sales strategy execution, inventory management, and compliance. Drive growth and enhance customer engagement while ensuring safety and operational e...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$96K - $207K *

Join a dynamic team to design and implement innovative technology solutions using Agile practices. Collaborate with cross-functional teams to deliver critical products while enhancing your skills in a...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$78K - $113K *

Innovate healthcare fraud prevention by leading complex investigations, evaluating medical necessity, and collaborating with regulatory agencies to ensure quality member care and safeguard plan assets...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$78K - $113K *

Unlock potential by leading complex investigations into healthcare fraud, waste, and abuse. Collaborate with regulatory agencies and internal teams to ensure compliance and safeguard member care while...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $189K *

Transform SAP ABAP development for mission-critical DoD logistics systems, ensuring alignment with regulatory requirements and optimizing user interfaces while collaborating across teams to enhance op...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$105K - $231K *

Accelerate progress at the forefront of SAP integration, driving complex data exchanges and ensuring compliance with DoD standards while enhancing transportation operations across diverse systems...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$75K - $158K *

Drive agile excellence by coaching teams in a scaled framework, facilitating planning, and enhancing collaboration. Engage with stakeholders to ensure successful delivery and continuous improvement in...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $189K *

Shape the future of network infrastructure by leading modernization efforts across classified and unclassified systems. Collaborate with teams to design secure, high-performance networks while ensurin...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$75K - $158K *

Join us to lead agile teams in a dynamic environment, coaching and facilitating processes to enhance productivity and collaboration. Drive successful project delivery while fostering strong relationsh...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$90K - $189K *

Contribute to critical government missions as a Release Train Engineer, facilitating Agile Release Train events, coaching teams, and driving continuous improvement to deliver value using cutting-edge...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$75K - $158K *

Elevate your career as a Senior Business Systems Analyst, driving modernization initiatives in federal financial systems. Collaborate with teams to analyze data, implement solutions, and lead developm...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Transform the member experience by owning the full lifecycle of features across a cutting-edge AI-first platform, leveraging technologies from React to GraphQL and AI services to deliver personalized...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

$100K - $120K *

Join a team that's driving growth in the commercial sector by leveraging data and AI solutions. As an Account Executive, you'll cultivate relationships, manage accounts, and optimize customer success...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$134K - $205K *

Drive civil and structural construction excellence by managing on-site activities, ensuring compliance with safety and quality standards, and collaborating with diverse teams to meet project milestone...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.