Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
Average Salary: $111,580
Asset Lead Medical Director - Obesity and Related Conditions
$217K - $294K *
Innovate the U.S. Cardiovascular & Metabolic Medical strategy, leading evidence generation and stakeholder engagement for chronic weight management. Collaborate cross-functionally to ensure launch rea...
6 days ago
Customer Quality Engineering Specialist
$68K - $109K *
Empower customer satisfaction by representing the Voice of the Customer, resolving cases through data-driven analysis, and coaching teams to enhance quality and prevent non-conformance. Drive cross-fu...
Reposted 6 days ago
$120K - $135K *
Elevate our proposal management efforts by leading strategic submissions, fostering collaboration among teams, and enhancing our pursuit capabilities to secure high-value projects that improve infrast...
Reposted 6 days ago
Product Manager - Wellness and Social Health
$86K - $138K *
Lead the charge in defining and executing a comprehensive product strategy, driving value across product portfolios. Collaborate with key stakeholders to align strategic vision while overseeing perfor...
Reposted 6 days ago
$120K - $145K *
Lead the charge in delivering complex renewable energy projects, ensuring safety, quality, and budget adherence. Collaborate with diverse stakeholders to drive project success from development through...
6 days ago
Intracept Clinical Specialist - Louisiana / Mississippi
$90K *
Empower surgical teams by providing expert clinical support and training on Intracept devices. This role involves case coverage, technical education, and ensuring compliance, all aimed at enhancing pa...
6 days ago
$90K - $100K *
Join a team that's driving franchise sales success by leading, coaching, and developing a high-performing sales team. Optimize processes, leverage analytics, and collaborate across departments to enha...
6 days ago
$80K - $95K *
Elevate your career as a Senior Accountant, driving day-to-day operations and enhancing internal processes. Collaborate with teams to transition activities, ensuring accuracy and scalability in a fast...
6 days ago
Software Engineer (Time & Billing)
$115K - $120K *
Innovate solutions for time capture and billing in a dynamic team. Leverage AI tools to enhance software development, ensuring accuracy and efficiency in invoicing processes while collaborating across...
6 days ago
$80K - $96K *
Join a team that's driving automation and digital transformation in government and defense. Leverage your RPA expertise to design, develop, and deploy innovative solutions while collaborating with div...
6 days ago
$74K - $91K *
Contribute to national health data collection efforts by leveraging your nursing expertise and survey research skills. Engage in participant-centered data collection, quality control, and training whi...
6 days ago
Direct of Strategic Sales- PR/ Comms/ Media
$119K - $221K *
Advance your career by driving strategic sales initiatives within large enterprises. Collaborate with cross-functional teams to exceed sales quotas and develop innovative solutions that meet client ne...
6 days ago
Founding Account Executive - Travel & Hospitality
$140K - $170K *
Join us to drive growth in the travel loyalty sector by building relationships with airlines, hotels, and gaming operators. You'll lead new business initiatives, shaping partnerships that enhance cust...
6 days ago
Vice President, Executive Planning Consultant - Southeast Market
$160K - $200K *
Lead the charge in providing tailored financial planning and investment strategies for senior executives. Collaborate with a dedicated team to enhance client relationships and drive business growth wh...
6 days ago
Lead Bioinformatics Scientist (Oncology)
$130K - $163K *
Champion the analytical validation of NGS assays, driving real-world evidence studies and collaborating with cross-functional teams to enhance oncology applications and support regulatory submissions...
6 days ago
$135K - $198K *
Contribute to leadership development and talent management initiatives while partnering with stakeholders to strengthen organizational capability and talent pipelines, ensuring alignment with workforc...
Reposted 6 days ago
$175K - $215K *
Lead the charge in driving strategic growth and client satisfaction by managing senior-level relationships, leveraging cross-functional resources, and delivering measurable business value within a por...
6 days ago
$100K - $120K *
Champion the clinician experience by designing and optimizing tools that enhance daily workflows, ensuring seamless integration of clinical data and improving patient care delivery in home settings...
6 days ago
Senior Software Engineer, Network Platform
$135K - $160K *
Shape the future of networking by designing and implementing advanced SDN orchestration systems for high-performance, isolated networking in distributed computing environments, enabling seamless acces...
6 days ago
$183K - $301K *
Accelerate growth by leading strategic partnerships and go-to-market initiatives in the healthcare ecosystem. Drive revenue through collaboration, executive influence, and innovative business models w...
6 days ago
Manager, Palliative Care (IKC)
$78K - $119K *
Lead the charge in enhancing palliative care operations, ensuring high-quality support for patients with advanced chronic illnesses. Collaborate with diverse teams to improve care coordination and pat...
6 days ago
Manager, Project Management (IC)
$54K - $159K *
Pioneer the implementation of customer benefit plans for self-funded clients, ensuring alignment with organizational goals. Lead project execution, manage risks, and coach teams to exceed client expec...
6 days ago
Clinical Documentation Integrity Supervisor
$110K - $159K *
Inspire excellence in clinical documentation by leading a team of specialists, ensuring quality assurance, and fostering professional development. Collaborate with stakeholders to enhance operational...
Reposted 6 days ago
Regional Sales Manager (RSM) - PNW (Remote)
$280K - $360K *
Accelerate progress at building and expanding a territory across the Pacific Northwest and Mountain Range States, driving enterprise software sales and fostering relationships with key stakeholders in...
6 days ago
$175K - $200K *
Join a team that's dedicated to overseeing compliance and security initiatives, including FedRAMP and SOC audits. Collaborate across departments to enhance data protection and drive organizational suc...
6 days ago
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.