Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$217K - $294K *

Innovate the U.S. Cardiovascular & Metabolic Medical strategy, leading evidence generation and stakeholder engagement for chronic weight management. Collaborate cross-functionally to ensure launch rea...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$68K - $109K *

Empower customer satisfaction by representing the Voice of the Customer, resolving cases through data-driven analysis, and coaching teams to enhance quality and prevent non-conformance. Drive cross-fu...

Reposted 6 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$120K - $135K *

Elevate our proposal management efforts by leading strategic submissions, fostering collaboration among teams, and enhancing our pursuit capabilities to secure high-value projects that improve infrast...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Technical Services

$86K - $138K *

Lead the charge in defining and executing a comprehensive product strategy, driving value across product portfolios. Collaborate with key stakeholders to align strategic vision while overseeing perfor...

RemoteRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Lead the charge in delivering complex renewable energy projects, ensuring safety, quality, and budget adherence. Collaborate with diverse stakeholders to drive project success from development through...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$90K *

Empower surgical teams by providing expert clinical support and training on Intracept devices. This role involves case coverage, technical education, and ensuring compliance, all aimed at enhancing pa...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $100K *

Join a team that's driving franchise sales success by leading, coaching, and developing a high-performing sales team. Optimize processes, leverage analytics, and collaborate across departments to enha...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$80K - $95K *

Elevate your career as a Senior Accountant, driving day-to-day operations and enhancing internal processes. Collaborate with teams to transition activities, ensuring accuracy and scalability in a fast...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$115K - $120K *

Innovate solutions for time capture and billing in a dynamic team. Leverage AI tools to enhance software development, ensuring accuracy and efficiency in invoicing processes while collaborating across...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Business Services

$80K - $96K *

Join a team that's driving automation and digital transformation in government and defense. Leverage your RPA expertise to design, develop, and deploy innovative solutions while collaborating with div...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$74K - $91K *

Contribute to national health data collection efforts by leveraging your nursing expertise and survey research skills. Engage in participant-centered data collection, quality control, and training whi...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$119K - $221K *

Advance your career by driving strategic sales initiatives within large enterprises. Collaborate with cross-functional teams to exceed sales quotas and develop innovative solutions that meet client ne...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$140K - $170K *

Join us to drive growth in the travel loyalty sector by building relationships with airlines, hotels, and gaming operators. You'll lead new business initiatives, shaping partnerships that enhance cust...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $200K *

Lead the charge in providing tailored financial planning and investment strategies for senior executives. Collaborate with a dedicated team to enhance client relationships and drive business growth wh...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$130K - $163K *

Champion the analytical validation of NGS assays, driving real-world evidence studies and collaborating with cross-functional teams to enhance oncology applications and support regulatory submissions...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$135K - $198K *

Contribute to leadership development and talent management initiatives while partnering with stakeholders to strengthen organizational capability and talent pipelines, ensuring alignment with workforc...

Reposted 6 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$175K - $215K *

Lead the charge in driving strategic growth and client satisfaction by managing senior-level relationships, leveraging cross-functional resources, and delivering measurable business value within a por...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Champion the clinician experience by designing and optimizing tools that enhance daily workflows, ensuring seamless integration of clinical data and improving patient care delivery in home settings...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $160K *

Shape the future of networking by designing and implementing advanced SDN orchestration systems for high-performance, isolated networking in distributed computing environments, enabling seamless acces...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$183K - $301K *

Accelerate growth by leading strategic partnerships and go-to-market initiatives in the healthcare ecosystem. Drive revenue through collaboration, executive influence, and innovative business models w...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Healthcare

$78K - $119K *

Lead the charge in enhancing palliative care operations, ensuring high-quality support for patients with advanced chronic illnesses. Collaborate with diverse teams to improve care coordination and pat...

Pascagoula, MSRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$54K - $159K *

Pioneer the implementation of customer benefit plans for self-funded clients, ensuring alignment with organizational goals. Lead project execution, manage risks, and coach teams to exceed client expec...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $159K *

Inspire excellence in clinical documentation by leading a team of specialists, ensuring quality assurance, and fostering professional development. Collaborate with stakeholders to enhance operational...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$280K - $360K *

Accelerate progress at building and expanding a territory across the Pacific Northwest and Mountain Range States, driving enterprise software sales and fostering relationships with key stakeholders in...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$175K - $200K *

Join a team that's dedicated to overseeing compliance and security initiatives, including FedRAMP and SOC audits. Collaborate across departments to enhance data protection and drive organizational suc...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.