Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$72K - $120K *

Unlock your potential by leading creative strategy and visual design initiatives. Drive brand evolution and campaign execution while mentoring teams to enhance the College Board's visual identity acro...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$140K - $150K *

Shape the future of foodservice by leading strategic account growth with top chains. Drive market penetration, manage key relationships, and develop actionable plans to enhance profitability and expan...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$95K - $115K *

Unlock operational excellence by optimizing revenue processes and enhancing client experiences. Collaborate with cross-functional teams to drive growth, efficiency, and data-driven decision-making thr...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$126K - $154K *

Help us shape the future of client training and adoption in healthcare technology. This role leads the design and delivery of impactful training programs, ensuring clients achieve operational excellen...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Join a team that's dedicated to safeguarding sensitive health information while enhancing security across cloud and application environments. As a Senior Security Engineer, you'll design and implement...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$97K - $127K *

Lead the charge in optimizing Salesforce CRM strategy to drive commercial growth. Collaborate with cross-functional teams to enhance user adoption, streamline processes, and leverage technology for im...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Elevate your career by designing and deploying GenAI applications that drive innovation. Collaborate with cross-functional teams to solve complex business challenges using cutting-edge AI technologies...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$140K - $167K *

Deliver impactful account-based marketing strategies by owning and scaling bespoke campaigns for enterprise clients. Collaborate with sales to drive engagement and optimize performance through innovat...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Shape the future of financial modeling by building and testing deep learning methods. Collaborate with a skilled team to transform innovative ideas into impactful solutions that enhance credit decisio...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$188K - $225K *

Advance your career by advising top-tier technology leaders globally, guiding them in overcoming challenges, implementing strategies, and leveraging insights to drive transformative change and organiz...

RemoteRemote

Reposted 6 days ago

  •   15+ years exp.  •   Business Services

$175K - $222K *

Engage in architecting high-volume autonomous agent pipelines, ensuring safety, performance, and compliance. Own the generator-verifier architecture and CI/CD processes while setting engineering stand...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's transforming healthcare by connecting groundbreaking products with clients. You'll lead onboarding, design impactful use cases, and advocate for customer success, ensuring seamless...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Healthcare

$186K - $218K *

Drive the development and operation of backend services for a subscription product, enhancing user experience and retention through scalable solutions and cross-functional collaboration...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$130K - $155K *

Accelerate financial transformation by leading planning systems architecture and a team of analysts. Drive scalable reporting and data integration to support strategic decision-making for senior leade...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$143K - $199K *

Strategize and optimize marketing technology architecture and integrations. Drive platform health and feature development while collaborating with cross-functional teams to build robust solutions that...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $165K *

Contribute to governance, risk, and compliance initiatives, leading audit remediation for SOC 2, TISAX, and DORA. Drive proactive risk management and maintain stakeholder confidence through transparen...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Media

$114K - $158K *

Drive financial excellence by leading integrated management of Technology spend, enhancing visibility, and optimizing costs through collaboration with cross-functional teams to improve processes and d...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$240K - $330K *

Pioneer growth in the healthcare sector by driving new business and cultivating strong client relationships. Utilize expert sales skills to oversee complex deals from prospecting to closing in a consu...

RemoteRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$480K - $500K+*

Transform measurement science by leading a skilled team to enhance content performance metrics, ensuring rigorous analysis and fostering individual growth while collaborating with cross-functional lea...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$130K - $155K *

Accelerate progress at a leading eCommerce firm by driving global business strategy, overseeing P&L, and enhancing marketplace operations. Leverage your expertise in digital marketing and account mana...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $190K *

Drive impactful multi-channel field marketing strategies that enhance demand generation, strengthen customer relationships, and optimize pipeline performance. Lead a high-performing team while collabo...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Drive efficiency and scalability in legal operations by optimizing processes, managing technology, and controlling costs. Lead cross-functional projects and enhance compliance initiatives to support t...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Transportation

$110K - $130K *

Optimize project execution by leading a team in Startup and Commissioning activities, ensuring timely delivery, quality standards, and adherence to budget while fostering a safe and collaborative work...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Drive compliance and policy excellence as a Senior HR Advisor, overseeing employee relations, complex cases, and immigration. Collaborate globally to harmonize policies during acquisition, leveraging...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$350K *

Shape the future of AI-driven automation by partnering with key accounts to drive strategic sales initiatives, ensuring customers achieve maximum value from innovative solutions in a high-performance...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.