Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From positions in Jackson and the Gulf Coast to opportunities in communities across the state, find roles that match your experience, skills, and career goals.

Professional Opportunities Across Mississippi

Mississippi employers hire experienced professionals across industries such as healthcare, finance, manufacturing, technology, energy, and business operations. Available roles and compensation vary by employer, location, and qualifications, so review each listing for details about responsibilities, salary, and requirements.

Search in Mississippi Cities and Regions

Find opportunities in major employment centers including Jackson, Gulfport, and Southaven, as well as other Mississippi communities. Use location and job-title filters to focus your search, and consider remote or hybrid listings when available.

Find a Role That Fits Your Career

Compare opportunities by seniority, specialty, and work arrangement. Keep your résumé current, highlight measurable results, and tailor your application to the qualifications in each listing. Ladders helps professionals explore vetted jobs with salaries of at least $100,000.

Start Your Mississippi Job Search

Browse Mississippi jobs on Ladders and take the next step toward a professional opportunity aligned with your expertise and compensation goals. Listings change frequently, so check back for new roles.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,063

Sort By: Relevance

$100K - $120K *

Elevate your career by leading a dynamic team in outsourced finance and accounting. Drive client success through exceptional service, innovative solutions, and strategic business development while men...

Today

  •   8 - 10 years exp.  •   Legal & Accounting

$110K - $130K *

Reimagine client finance solutions by leading a dynamic team, enhancing service delivery, and driving business growth through innovative strategies and technology integration. Foster relationships and...

Today

  •   8 - 10 years exp.  •   Legal & Accounting

$80K - $95K *

Contribute to dental practice success by delivering impactful, in-person training on digital workflows and intraoral scanning. Collaborate with clinicians and staff to enhance clinical performance and...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$125K - $225K *

Join a team that's driving innovation in AI by developing scalable backend systems in Go, Python, and Java. Tackle complex challenges while enhancing distributed architectures to empower high-performa...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$120K - $151K *

Shape the product roadmap and drive delivery from discovery to launch, collaborating with cross-functional teams to ensure customer-centric solutions and measurable business outcomes in a dynamic B2B...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$71K - $113K *

Contribute to project success by managing cost and schedule for plant outages. Collaborate with project teams to analyze budgets, track progress, and ensure timely reporting, all while adhering to pro...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Energy & Utilities

$93K - $104K *

Join a nationwide team as a Physical Therapist Assistant, delivering essential rehab services across various settings while enhancing patient independence under expert supervision. Enjoy the flexibili...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$85K - $135K *

Collaborate to drive technical issue resolution and enhance support systems while serving enterprise clients across our AI platform, ensuring seamless communication and operational excellence in a fas...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Finance & Insurance

$144K - $211K *

Lead the charge in managing complex Industrial Controls workstreams, ensuring seamless execution of NPI programs. Collaborate across teams to deliver innovative automation solutions on time and within...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$90K - $110K *

Transform complex systems through expert programming in Natural and ADABAS. Lead large-scale projects on IBM Mainframe/Linux, enhancing automated eligibility systems while providing strategic recommen...

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$142K - $235K *

Deliver strategic leadership in driving sales growth across non-commercial channels. Manage a team to implement innovative strategies, enhance customer partnerships, and achieve financial goals while...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Food & Beverages

$116K - $194K *

Elevate your career by joining a dynamic engineering team focused on ATM and TCR technologies. As a key technical specialist, you'll enhance customer-facing banking services through innovative solutio...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $167K *

Join a team that's driving impactful earned media strategies in a dynamic, fast-paced environment. Lead media relations, secure placements, and maintain brand consistency while leveraging AI tools for...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$224K - $431K *

Join a team that's redefining AI networking by driving innovation in performance and scalability of distributed systems, optimizing data processing for large language models and generative AI workload...

RemoteRemote

Reposted today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$85K - $100K *

Analyze performance metrics to empower ACOs in Value-Based Care programs. Collaborate with teams to provide actionable insights, track KPIs, and optimize risk scores, driving data-driven decisions for...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$76K - $87K *

Unlock potential by delivering personalized patient care through advanced technology and collaboration with a dedicated dental team. Enjoy flexible scheduling and ongoing professional development in a...

Today

  •   Less than 5 years exp.  •   Healthcare

$76K - $87K *

Empower patient care by joining a dynamic team that values collaboration, innovation, and professional growth. Enjoy flexible scheduling and advanced technology while delivering exceptional dental hyg...

Today

  •   Less than 5 years exp.  •   Healthcare

$79K - $117K *

Deliver strategic leadership by optimizing patient billing processes to enhance the financial health of healthcare services, ensuring compliance with regulations while driving team performance and cus...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$160K *

Drive growth by leading strategic initiatives across Google Workspace, Cloud, and Gemini. Empower a high-performing consulting team while enhancing partner engagement and optimizing category performan...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$99K - $131K *

Innovate data-driven strategies to enhance decision-making and drive growth. Lead complex data analysis, transform insights into actionable recommendations, and collaborate across teams to optimize pe...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$85K *

Engage with US partner institutions to drive adoption and renewals, fostering strong relationships with faculty and leadership. Shape the future of educational success through strategic account manage...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$231K - $244K *

Lead the charge in shaping proactive legal strategies to navigate evolving regulatory landscapes, ensuring compliance and fostering collaboration across teams, while addressing legislative challenges...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Consumer Technology

$193K - $244K *

Support business growth by drafting and negotiating partner agreements, providing strategic legal advice, and leading cross-functional projects. Collaborate with internal teams to ensure compliance an...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Consumer Technology

$192K - $202K *

Lead the technical roadmap and modernize data solutions infrastructure, enhancing off-platform integrations and measurement capabilities while driving AI-first engineering initiatives and cross-team c...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Consumer Technology

$128K - $135K *

Unlock potential by expanding grassroots engagement across key regions, connecting with shoppers and communities to advocate for app-based workers and food security. Drive digital strategies and build...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of jobs can I find in Mississippi on Ladders?question toggle

    You can explore professional opportunities across fields such as healthcare, finance, manufacturing, technology, energy, and business operations. Roles and availability vary over time.

  • Are Mississippi jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional jobs that pay $100,000 or more. Check each listing for compensation details, qualifications, and other job-specific information.

  • Where in Mississippi can I search for jobs?question toggle

    Search across the state, including employment centers such as Jackson, Gulfport, and Southaven. You can use location filters to narrow results.

  • How can I find remote or hybrid jobs based in Mississippi?question toggle

    Use available work-arrangement filters or review listing details to identify remote and hybrid opportunities. Availability depends on the employer and role.

  • How do I improve my chances of getting hired for a Mississippi job?question toggle

    Tailor your résumé to the role, emphasize relevant experience and measurable outcomes, and ensure you meet the listed qualifications before applying.