Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$110K - $130K *

Unlock potential by leading strategic digital transformation sales across industries. Drive complex pursuits integrating Cybersecurity, AI solutions, and Manufacturing Operations Management to enhance...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Join us to lead transformational sales in digital operations, driving complex solutions across cybersecurity and manufacturing. Collaborate with stakeholders to unlock value and accelerate customer ou...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$145K - $215K *

Elevate your career by managing key accounts in the rare disease sector. Drive sales, build relationships with healthcare professionals, and ensure compliance while achieving ambitious territory goals...

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$104K - $141K *

Lead the charge in transforming Human Genetics strategy into actionable plans, ensuring measurable progress across R&D. Collaborate with cross-functional teams to align priorities and drive successful...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$144K - $194K *

Accelerate progress at the forefront of oncology marketing by leading global initiatives, synthesizing insights, and driving execution across teams to enhance product strategies and launch readiness...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$145K - $215K *

Elevate your career by driving sales and education for innovative healthcare solutions. In this role, you'll manage accounts, build relationships with healthcare professionals, and enhance patient car...

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Empower healthcare transformation by educating Integrated Delivery Networks on EHR systems. Collaborate with cross-functional teams to enhance patient management and care delivery through innovative h...

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$155K - $210K *

Shape the future of regulatory policy by leading initiatives that influence key decisions and drive alignment across teams. Collaborate with stakeholders to advocate for impactful policies that suppor...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$193K - $262K *

Lead and optimize field effectiveness initiatives, driving sales performance through insights and operational excellence. Manage a high-performing team while collaborating cross-functionally to enhanc...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$204K - $276K *

Lead the charge in global observational research, driving clinical operational strategy and execution. Collaborate with cross-functional teams to ensure quality and efficiency in evidence generation t...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$145K - $215K *

Empower healthcare professionals by driving product demand and managing accounts. Collaborate with teams to address client needs and exceed sales goals in a dynamic environment focused on rare disease...

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Champion strategic workforce planning and AI-driven work design to enhance capability, improve productivity, and advance internal mobility across teams. Drive tools and strategies aligning workforce p...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Healthcare

$285K - $385K *

Lead regulatory due diligence for clinical/commercial assets, assessing risks and strategies for licensing, acquisitions, and partnerships. Collaborate across teams to ensure regulatory integration in...

RemoteRemote

5 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$189K - $246K *

Lead clinical pharmacology strategies, integrating PK/PD assessments across development phases. Collaborate with cross-functional teams to guide decision-making and regulatory submissions, ensuring al...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$75K - $150K *

Drive branch operations by leading teams to achieve financial goals, enhance customer service, and implement strategic initiatives. Collaborate across departments to optimize performance and foster a...

5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$145K - $220K *

Shape the future of Finance by managing AI transformation initiatives, collaborating with stakeholders to identify high-value use cases, and ensuring successful integration of AI solutions within Fina...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Information Technology

$121K - $170K *

Lead the transformation of storage solutions by leveraging deep technical expertise in NetApp Keystone and Storage-as-a-Service. Collaborate with customers to architect tailored solutions that optimiz...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$91K - $128K *

Join a team that's dedicated to empowering educators through impactful training sessions. You'll create engaging content and deliver customized Google for Education engagements, enhancing customer rel...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$176K - $236K *

Lead the charge in global regulatory project management, driving oncology strategies and submissions across regions. Collaborate with cross-functional teams to ensure compliance and timely market acce...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$114K - $154K *

Transform supply chain operations by managing SAP systems and processes, ensuring seamless logistics and distribution support. Drive efficiency and issue resolution across Commercial and Clinical Supp...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$178K - $238K *

Drive impactful oncology drug development by leading program management, optimizing team efficiency, and ensuring strategic alignment across global projects to enhance patient outcomes and organizatio...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$97K - $165K *

Shape the future of cloud solutions by leading technical relationships, validating AWS architectures, and driving presales strategies. Empower teams through mentorship while ensuring secure, scalable...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Business Services

$121K - $206K *

Lead the charge in architecting and delivering Microsoft Azure and 365 solutions for SMBs. Oversee cloud migrations, security implementations, and project management while fostering strong partner rel...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Business Services

$105K - $149K *

Drive security excellence by enhancing data protection and detection capabilities. Collaborate with cross-functional teams to implement DLP policies, automate processes, and ensure enterprise systems...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$99K - $117K *

Lead strategic commercial initiatives to enhance performance and profitability across a portfolio of franchised hotels. Collaborate with stakeholders to drive revenue growth, optimize market share, an...

United StatesRemote

Reposted 5 days ago

  •   11 - 15 years exp.  •   Hospitality & Recreation

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.