Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
Average Salary: $111,580
Sales Executive - Secure Digital Operations, Automotive & Tire
$110K - $130K *
Unlock potential by leading strategic digital transformation sales across industries. Drive complex pursuits integrating Cybersecurity, AI solutions, and Manufacturing Operations Management to enhance...
5 days ago
Sales Executive, Secure Digital Operations - OEM
$110K - $130K *
Join us to lead transformational sales in digital operations, driving complex solutions across cybersecurity and manufacturing. Collaborate with stakeholders to unlock value and accelerate customer ou...
5 days ago
Account Manager/Specialty Account Manager -KRYSTEXXA (Rare Disease) - Shreveport, LA
$145K - $215K *
Elevate your career by managing key accounts in the rare disease sector. Drive sales, build relationships with healthcare professionals, and ensure compliance while achieving ambitious territory goals...
5 days ago
Business Performance Manager, Human Genetics
$104K - $141K *
Lead the charge in transforming Human Genetics strategy into actionable plans, ensuring measurable progress across R&D. Collaborate with cross-functional teams to align priorities and drive successful...
5 days ago
Global Marketing Senior Manager - Oncology (IMDELLTRA)
$144K - $194K *
Accelerate progress at the forefront of oncology marketing by leading global initiatives, synthesizing insights, and driving execution across teams to enhance product strategies and launch readiness...
5 days ago
Account Manager / Specialty Account Manager - IgG4 - (Rare Disease) - Jackson, MS
$145K - $215K *
Elevate your career by driving sales and education for innovative healthcare solutions. In this role, you'll manage accounts, build relationships with healthcare professionals, and enhance patient car...
5 days ago
Medical Value and Health Information Technology (MVHIT) Manager - Health IT Liaison - South Central
$110K - $130K *
Empower healthcare transformation by educating Integrated Delivery Networks on EHR systems. Collaborate with cross-functional teams to enhance patient management and care delivery through innovative h...
5 days ago
Regulatory Policy and Intelligence Associate Director
$155K - $210K *
Shape the future of regulatory policy by leading initiatives that influence key decisions and drive alignment across teams. Collaborate with stakeholders to advocate for impactful policies that suppor...
5 days ago
Director, Field Effectiveness, Obesity and Related Conditions
$193K - $262K *
Lead and optimize field effectiveness initiatives, driving sales performance through insights and operational excellence. Manage a high-performing team while collaborating cross-functionally to enhanc...
5 days ago
Senior Director, Observational Research, CPSO
$204K - $276K *
Lead the charge in global observational research, driving clinical operational strategy and execution. Collaborate with cross-functional teams to ensure quality and efficiency in evidence generation t...
5 days ago
Account Manager / Specialty Account Manager - UPLIZNA (Rare Disease), Neurology-Jackson, MS
$145K - $215K *
Empower healthcare professionals by driving product demand and managing accounts. Collaborate with teams to address client needs and exceed sales goals in a dynamic environment focused on rare disease...
5 days ago
Director, Workforce Strategy & Transformation
$150K - $180K *
Champion strategic workforce planning and AI-driven work design to enhance capability, improve productivity, and advance internal mobility across teams. Drive tools and strategies aligning workforce p...
Reposted 5 days ago
Vice President, Regulatory Strategy Diligence
$285K - $385K *
Lead regulatory due diligence for clinical/commercial assets, assessing risks and strategies for licensing, acquisitions, and partnerships. Collaborate across teams to ensure regulatory integration in...
5 days ago
Director, Clinical Pharmacology
$189K - $246K *
Lead clinical pharmacology strategies, integrating PK/PD assessments across development phases. Collaborate with cross-functional teams to guide decision-making and regulatory submissions, ensuring al...
5 days ago
$75K - $150K *
Drive branch operations by leading teams to achieve financial goals, enhance customer service, and implement strategic initiatives. Collaborate across departments to optimize performance and foster a...
5 days ago
Sr. Finance Transformation Manager (Remote)
$145K - $220K *
Shape the future of Finance by managing AI transformation initiatives, collaborating with stakeholders to identify high-value use cases, and ensuring successful integration of AI solutions within Fina...
5 days ago
Consulting Solution Architect - NetApp
$121K - $170K *
Lead the transformation of storage solutions by leveraging deep technical expertise in NetApp Keystone and Storage-as-a-Service. Collaborate with customers to architect tailored solutions that optimiz...
5 days ago
Senior Education Consultant - Google Workspace
$91K - $128K *
Join a team that's dedicated to empowering educators through impactful training sessions. You'll create engaging content and deliver customized Google for Education engagements, enhancing customer rel...
5 days ago
Director, Global Regulatory Project and Submission Management
$176K - $236K *
Lead the charge in global regulatory project management, driving oncology strategies and submissions across regions. Collaborate with cross-functional teams to ensure compliance and timely market acce...
5 days ago
Manager, Global Supply Chain Capabilities
$114K - $154K *
Transform supply chain operations by managing SAP systems and processes, ensuring seamless logistics and distribution support. Drive efficiency and issue resolution across Commercial and Clinical Supp...
5 days ago
Director, Oncology Program Management
$178K - $238K *
Drive impactful oncology drug development by leading program management, optimizing team efficiency, and ensuring strategic alignment across global projects to enhance patient outcomes and organizatio...
5 days ago
$97K - $165K *
Shape the future of cloud solutions by leading technical relationships, validating AWS architectures, and driving presales strategies. Empower teams through mentorship while ensuring secure, scalable...
Reposted 5 days ago
Sr Microsoft Solutions Architect
$121K - $206K *
Lead the charge in architecting and delivering Microsoft Azure and 365 solutions for SMBs. Oversee cloud migrations, security implementations, and project management while fostering strong partner rel...
Reposted 5 days ago
Security Engineer - DLP and Insider threat
$105K - $149K *
Drive security excellence by enhancing data protection and detection capabilities. Collaborate with cross-functional teams to implement DLP policies, automate processes, and ensure enterprise systems...
Reposted 5 days ago
Area Director, Franchise Performance (Virginia/North Carolina)
$99K - $117K *
Lead strategic commercial initiatives to enhance performance and profitability across a portfolio of franchised hotels. Collaborate with stakeholders to drive revenue growth, optimize market share, an...
Reposted 5 days ago
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.