Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,974

Sort By: Relevance

$104K - $166K *

Lead and execute comprehensive penetration testing assessments to identify and remediate security vulnerabilities across applications, networks, and cloud environments, while providing technical guida...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$104K - $166K *

Transform enterprise file transfer operations by leveraging your expertise in IBM Sterling and Unix/Linux systems. Drive efficiency and security in a critical financial services environment while coll...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$104K - $166K *

Lead strategic sourcing and procurement for Defense and Health sectors, managing a team to drive supplier value, cost savings, and compliance while supporting growth and operational excellence across...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$112K - $179K *

Optimize cloud infrastructure and CI/CD processes as a Cloud DevOps Engineer. Collaborate with Agile teams to enhance security, automate deployments, and ensure mission-critical support while leveragi...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$142K - $177K *

Lead legal initiatives by drafting documents, managing records, and providing counsel. Collaborate with executives to shape organizational direction while ensuring compliance and supporting continuous...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$152K - $190K *

Drive the future of data analytics by leading a dynamic team to enhance enterprise data strategies, governance, and insights that align with business objectives and foster innovation across the organi...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$138K - $165K *

Unlock potential by leveraging your data science expertise to innovate generative AI solutions. Lead cross-functional collaborations, build evaluation frameworks, and drive best practices within a dyn...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$160K - $190K *

Transform corporate governance and compliance by advising on legal matters, preparing SEC filings, and managing risk programs. Collaborate with stakeholders to ensure adherence to regulations while dr...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Join a team that's dedicated to enhancing client experiences through exceptional facility management. Oversee multiple locations, collaborate on strategic initiatives, and ensure a welcoming atmospher...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$90K - $128K *

Transform data-driven applications by leveraging your software development expertise. Collaborate with multidisciplinary teams to design, implement, and enhance solutions that improve decision-making...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$159K - $215K *

Join a team that's driving operational excellence across 25+ sites, overseeing facilities, real estate, and security operations to ensure safe, efficient environments that support high-quality care de...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $135K *

Lead the charge in ensuring the quality and reliability of Enrollment data operations. Collaborate with offshore teams to execute timely processes, troubleshoot issues, and drive continuous improvemen...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Join a team that's enhancing data integration for the U.S. Coast Guard. As a Senior Systems Engineer, you'll lead the implementation and maintenance of the Cloud Data Pipeline, ensuring robust data sh...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$114K - $145K *

Unlock your potential as a Data Engineer, transforming raw data into impactful systems. Collaborate with stakeholders, optimize data architecture, and drive efficiency through automation while managin...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$90K - $120K *

Help us accelerate progress by supporting project managers in delivering financial analyses and technical reports, while collaborating with a dynamic team to drive impactful solutions in utility finan...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Business Services

$180K - $200K *

Lead strategic initiatives within the Financial Management Group, focusing on client growth, project delivery, and team development while mentoring staff and enhancing service offerings in utility fin...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Business Services

$130K - $175K *

Empower financial analysis and project management in the utility sector. Lead cost-of-service studies, develop client relationships, and mentor junior staff while ensuring quality and timely delivery...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Business Services

$95K - $158K *

Engage with high voltage operations, ensuring safe, reliable maintenance and training for renewable energy projects. Lead technical support and oversee compliance for BOP and substation systems across...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $200K *

Lead the charge in modernizing backend capabilities and AWS infrastructure, ensuring secure, reliable software development at scale. Collaborate with teams to enhance platform usability and drive prod...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Staffing

$105K - $124K *

Lead and optimize research intern activities, ensuring alignment with project goals and technical standards. Manage workflows, provide coaching, and conduct hands-on research while supporting the Dire...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Unlock potential by leading innovative strategies for AI-enabled maternal care. Drive program implementation, manage complex projects, and engage stakeholders to enhance health outcomes in low- and mi...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$125K *

Join a team that's redefining nonprofit leadership. Leverage your expertise to empower organizations, enhance governance, and drive sustainable growth across diverse communities while navigating compl...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Transform your career by leading a dynamic sourcing team, driving strategic initiatives, and shaping sourcing solutions for critical energy infrastructure projects. Your expertise will influence decis...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$193K - $252K *

Join a team that's passionate about solving complex business challenges. As a Principal Solutions Engineer, you'll engage with enterprise clients, drive strategic relationships, and showcase the value...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$101K - $125K *

Drive the execution of immersive projects by providing technical oversight and support, ensuring seamless integration and coordination with partners globally while maintaining high standards of qualit...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.