Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
Average Salary: $110,974
Manager, Data Protection Analysts (Americas)
$120K - $145K *
Shape the future of data protection by leading a high-performing team of analysts. Drive incident response, enhance security strategies, and collaborate with clients to mitigate risks in a fast-paced...
5 days ago
Talent Acquisition and Employee Engagement Manager
$100K - $120K *
Partner with us to shape the future of talent acquisition and employee engagement. Lead strategies that attract, retain, and support exceptional talent while enhancing the employee experience across a...
5 days ago
Sr. Manager, Global Channel Partner Marketing
$135K - $160K *
Shape the future of partner marketing by building and executing joint plans with key resellers and distributors, driving engagement and pipeline growth through innovative campaigns and strategic commu...
5 days ago
$150K - $180K *
Unlock your potential as a Senior Applied AI Engineer, leading teams to design and deliver impactful AI solutions. Drive technical excellence and mentor engineers while shaping the future of AI system...
5 days ago
Sr. Security Operations Manager
$172K - $269K *
Lead and modernize global security operations, managing a distributed team while enhancing detection strategies and incident response. Drive AI integration for efficiency and ensure accountability thr...
5 days ago
Senior Product Manager (Healthcare Data Products)
$120K - $145K *
Transform healthcare data products by leading strategy, execution, and cross-functional collaboration. Drive product-market fit and commercialization for API-based solutions, ensuring alignment with c...
5 days ago
Sales Manager - Australia/New Zealand Market
$100K - $120K *
Accelerate sales growth by leading strategies and initiatives across the ANZ market. Collaborate with a multidisciplinary team to drive customer engagement, develop market strategies, and achieve reve...
Reposted 5 days ago
$95K - $115K *
Transform procurement operations by leading strategy and team management in a regulated manufacturing environment. Drive supplier performance, cost efficiency, and material availability to support pro...
5 days ago
Software Engineer 4/5 - Model Serving Systems, AI Platform
$466K - $500K+*
Unlock potential by developing scalable AI/ML model serving infrastructure. Collaborate cross-functionally to enhance performance and availability of high-traffic systems, driving innovation in a dyna...
5 days ago
Staff Product Manager, Activation
$135K - $160K *
Join a team that's redefining onboarding experiences by optimizing customer activation and conversion. You'll lead the charge in creating a seamless journey for new users, ensuring they derive value f...
5 days ago
Cloud Concierge Technical Analyst
$80K - $95K *
Drive cloud onboarding success by guiding application owners through migration complexities, ensuring effective communication and collaboration across teams to enhance operational efficiency and suppo...
5 days ago
Director Strategy for Advanced Networking and Enterprise
$156K - $215K *
Empower innovation in advanced networking and enterprise solutions by defining strategic roadmaps and driving product lifecycle planning across high-speed networking, optical technologies, and AI plat...
5 days ago
Client Sales Enterprise Account Executive
$110K - $145K *
Empower enterprise growth by managing high-value accounts in a dynamic SaaS environment. Drive the full sales cycle, build executive relationships, and navigate complex negotiations to achieve impactf...
5 days ago
Strategic Solution Sales Executive
$140K - $185K *
Drive strategic growth by identifying and developing solution-specific opportunities within key accounts, leveraging industry expertise to influence client transformation initiatives and enhance sales...
5 days ago
$150K - $180K *
Transform the Federal landscape by leading enterprise sales efforts, engaging with SES leaders, and driving digital transformation across major accounts. Collaborate with cross-functional teams to ach...
5 days ago
Diagnosis-Related Group (DRG) Auditor III
$73K - $98K *
Join a team that's dedicated to excellence in DRG auditing. Leverage your expertise in MS-DRG and APR-DRG coding to ensure accuracy and compliance while working remotely. Enjoy a collaborative environ...
5 days ago
$120K - $155K *
Join a team that's dedicated to nurturing and expanding client relationships in the Major Market sector. Drive revenue growth through upselling and cross-selling while ensuring long-term satisfaction...
5 days ago
IT Subject Matter Expert (SME)
$100K - $175K *
Transform operations by leveraging your expertise in IT and cybersecurity. Collaborate with leaders to enhance processes, drive efficiency, and ensure compliance while mentoring teams and aligning str...
Reposted 5 days ago
Staff Machine Learning Engineer, Ads Forecasting & Scenarios
$230K - $322K *
Lead the development of machine learning models to enhance advertiser insights, optimizing campaign performance through advanced forecasting and scenario analysis. Collaborate across teams to drive im...
5 days ago
Senior Software Engineer, Compute Platform
$165K - $225K *
Champion the development of a GPU-accelerated compute platform, enhancing AI training and research capabilities. Collaborate with cross-functional teams to design orchestration systems that optimize r...
5 days ago
Senior Strategic Marketing Manager | East Coast | Remote
$160K - $195K *
Join a team that's redefining account marketing for major clients. Collaborate with cross-functional partners to drive growth, enhance customer engagement, and create tailored marketing strategies tha...
5 days ago
$80K - $95K *
Innovate nursing practices by leading patient care initiatives, enhancing service delivery, and fostering collaboration across departments to improve satisfaction and operational efficiency in a dynam...
5 days ago
Regional Vice President, Central | Remote |
$450K - $475K *
Drive revenue growth by leading a team of Regional Directors, fostering collaboration, and ensuring alignment with company goals. Your leadership will shape the region's success and culture while enha...
5 days ago
Marketing Manager, Large Practice Services
$99K - $155K *
Drive impactful marketing initiatives by executing campaigns, managing operations, and collaborating with teams to enhance brand visibility and support sales growth. Leverage data insights to optimize...
5 days ago
$150K - $180K *
Transform the future of AI-driven infrastructure products by leading strategic growth initiatives, collaborating closely with Marketing and Engineering, and influencing key product decisions for optim...
Reposted 5 days ago
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.