Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,974

Sort By: Relevance

$77K - $118K *

Lead the design and development of substation and transmission line projects, collaborating with engineers and project teams to deliver high-quality civil site designs and ensure compliance with regul...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Technical Services

$141K - $196K *

Unlock potential by developing causal machine-learning models to optimize customer offers, analyzing complex data, and translating findings into actionable strategies for enhanced conversion rates acr...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$168K - $232K *

Lead the charge in executing innovative financing strategies for our AI lending marketplace. Collaborate with investors and stakeholders to drive structured transactions, ensuring scalable funding sol...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$78K - $85K *

Build your career in outpatient orthopedic physical therapy, focusing on patient care while enjoying competitive pay, mentorship, and growth opportunities in a supportive environment...

4 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $90K *

Champion customer success by managing strategic accounts, driving retention, and ensuring satisfaction through effective onboarding and ongoing support. Collaborate with internal teams to achieve cust...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$200K - $250K *

Lead the charge in advancing electrical infrastructure services, driving strategic growth and operational excellence across heavy industrial sectors. Foster client relationships and mentor teams to en...

United StatesRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Energy & Utilities

$120K - $145K *

Unlock potential by leading strategic partnerships and driving growth initiatives. Collaborate cross-functionally to enhance business opportunities and ensure partner success through data-driven insig...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$140K - $160K *

Lead strategic life sciences accounts, driving growth and team development while ensuring project success and client satisfaction through strong relationships and innovative solutions...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$85K - $124K *

Drive impactful SAP projects as a Project Manager/Scrum Master, leading teams to deliver innovative solutions. Collaborate with stakeholders, manage product backlogs, and ensure agile practices to mee...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$84K - $120K *

Lead the charge in coordinating installations of advanced imaging solutions, ensuring seamless communication and execution throughout the pre-installation and installation phases to enhance customer s...

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$250K - $300K *

Join a dynamic team as you drive enterprise sales across mid-market to Fortune 500 accounts. Own the entire sales cycle, engage multi-stakeholder buying committees, and leverage AI tools to redefine b...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$190K - $220K *

Shape the future of global accounts by aligning technical strategy with business vision. Engage with C-suite stakeholders to drive innovation, define KPIs, and integrate AI analytics into service deli...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$200K - $240K *

Drive the growth and impact of the B Corp movement in the US and Canada, leading strategic initiatives, fostering partnerships, and enhancing community engagement to position purpose-driven business a...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Business Services

$80K - $95K *

Elevate nursing excellence by directing patient care activities and collaborating with teams to enhance service delivery, optimize resources, and ensure compliance with standards, fostering satisfacti...

4 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$130K - $160K *

Join a team that's dedicated to optimizing customer success through technical expertise. As a trusted advisor, you'll manage relationships, guide deployments, and ensure seamless adoption for federal...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Transform higher education through innovative Salesforce solutions, guiding institutions in architecture design, implementation, and best practices to enhance student engagement and operational effici...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Staffing

$107K - $161K *

Join a team that's dedicated to managing complex Auto and General Liability claims. You'll handle high exposure cases, oversee litigation, and develop resolution strategies while collaborating with va...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$160K - $200K *

Drive strategic growth and operational excellence in cardiology, fostering physician partnerships and overseeing clinical and financial performance to enhance patient care and organizational success...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$83K - $133K *

Optimize customer interactions by managing order entry, tracking, and support activities across local business units and agent accounts, ensuring timely delivery and effective communication in a dynam...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$175K - $210K *

Unlock potential by leading a transformative sales organization across diverse markets. Drive growth through strategic sales initiatives, team development, and robust forecasting, while transitioning...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$190K - $230K *

Lead the accounting and financial reporting functions within a growing healthcare organization. Drive integrity across multiple entities, ensure compliance, and strategize cash management while suppor...

United StatesRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Healthcare

$135K - $160K *

Lead the strategic design and management of comprehensive benefits programs, ensuring alignment with employee needs and company objectives. Drive innovation and compliance while enhancing employee eng...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Grow your career by driving revenue growth in the acute care market through new customer acquisition and account expansion. Manage the full sales lifecycle while collaborating with internal teams to d...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$228K - $342K *

Advance the future of R&D governance and portfolio management by leading strategic decision-making processes, optimizing operational efficiency, and ensuring seamless progression of therapeutic assets...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$105K - $120K *

Engage with public health labs to enhance customer satisfaction and drive sales. Collaborate with cross-functional teams to execute market strategies and foster relationships with key opinion leaders...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.