Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,974

Sort By: Relevance

$190K - $267K *

Champion innovation by leading cross-functional teams to design and deliver scalable, high-performance infrastructure solutions that enhance reliability and efficiency across diverse applications and...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Media

$130K - $160K *

Join a team that's building from the ground up, shaping the engineering foundation and culture while collaborating closely with leadership to define and deliver innovative products...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$500K+*

Join a team that's driving sales success through strategic leadership and collaboration. Oversee resource planning, manage budgets, and coach a team of Regional Sales Managers while achieving revenue...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$250K - $500K+*

Optimize and innovate software kernels for hardware integration, collaborating with ML Research and Hardware Engineering teams to enhance performance and efficiency in cutting-edge technology applicat...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$165K - $225K *

Elevate infrastructure capabilities by designing and implementing a unified platform that integrates bare-metal servers, storage, and networking for large-scale computation and AI workloads, ensuring...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Champion growth by owning the full sales cycle, educating clients, and driving custom part sourcing for hardware companies. Collaborate with a remote team to deliver exceptional service and build last...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$170K - $200K *

Transform customer experiences by providing technical expertise and solutions. Collaborate with sales and engineering teams to deliver impactful product demonstrations and address technical challenges...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $200K *

Join a team that's dedicated to advancing clinical research by leading operational aspects of trials, ensuring compliance with protocols and regulations, and fostering collaboration among stakeholders...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $220K *

Lead transformative technology initiatives as a strategic Chief Technology Officer, driving modernization and AI integration while ensuring business continuity and team development in a dynamic softwa...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Enterprise Technology

$135K - $145K *

Lead the charge in optimizing payroll integration operations, managing teams, and driving strategic alignment across functions. Elevate customer experience through data-driven insights and innovative...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$189K - $231K *

Innovate and shape the future of AI platforms as a Senior Engineer, designing and building critical subsystems for enterprise Kubernetes environments. Collaborate with customers and mentor engineers t...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$187K - $281K *

Redefine market access strategies by leading payer engagement to enhance patient access to genomic testing. Collaborate cross-functionally to drive favorable coverage and reimbursement policies, ensur...

United StatesRemote

4 days ago

  •   15+ years exp.  •   Pharmaceuticals & Biotech

$320K - $405K *

Transform the future of data center engineering by resolving on-site technical issues, collaborating with contractors, and ensuring project success through effective problem-solving and communication...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $160K *

Create impactful solutions as a Senior Product Engineer, owning projects from concept to delivery. Collaborate with a dynamic team, leveraging AI tools to enhance development while mentoring peers and...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Business Services

$466K - $500K+*

Elevate your career by building a cutting-edge ML data platform that enhances productivity for ML practitioners. Collaborate with experts to create innovative solutions for feature computation and sha...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$200K - $250K *

Champion the evolution of fraud prevention strategies, enhancing customer experience while safeguarding against risks. Collaborate cross-functionally to design innovative solutions that balance securi...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Inspire enterprise-wide transformation initiatives that enhance growth and innovation. Collaborate across departments to identify opportunities, leverage AI, and apply data-driven insights to drive im...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$180K - $220K *

Lead the evaluation of outpatient referrals and inpatient admissions for medical necessity, utilizing guidelines and criteria to ensure quality care. Collaborate with providers and mentor UM nurses to...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Join a dynamic team as you develop and maintain dealer partnerships, driving growth and enhancing customer satisfaction in the auto finance sector. Leverage your expertise to navigate market trends an...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $160K *

Elevate your career by supporting senior leaders in a dynamic tech environment. Manage complex calendars, coordinate travel, and streamline processes to enhance productivity and drive success across g...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Unlock potential by leading a dynamic SQA team to enhance software quality. Drive testing strategies, mentor team members, and ensure compliance with best practices while managing multiple projects in...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $125K *

Analyze customer needs and drive product initiatives using AI tools. Own features from discovery to delivery, ensuring alignment with business priorities and quality outcomes while collaborating acros...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$150K - $170K *

Join a team that's expanding strategic partnerships with consulting firms to enhance supply chain solutions. Drive growth through collaboration, relationship management, and innovative go-to-market st...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$210K - $230K *

Drive your career with a dynamic role focused on enterprise B2B sales, where you'll cultivate relationships, leverage data insights, and collaborate cross-functionally to close high-value deals in a f...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$122K - $205K *

Drive measurable SEO results by owning key surfaces and experiments, leveraging AI tools for hands-on building, and collaborating across teams to enhance organic growth and visibility in a dynamic, re...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.