Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,974

Sort By: Relevance

$69K - $119K *

Transform the landscape of clinical documentation by educating and mentoring teams, ensuring compliance, and enhancing documentation accuracy to optimize patient care and coding outcomes...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Drive new business generation in captive management solutions, focusing on multifamily risk and large P&C alternatives. Build relationships with brokers and multifamily owners while managing the full...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$155K - $185K *

Join a dynamic team to oversee security operations, incident response, and automation initiatives. Collaborate with cross-functional teams to enhance security practices and develop tools that streamli...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$82K - $132K *

Unlock potential in revenue cycle management by leading innovative solutions, optimizing processes, and collaborating across departments to enhance operational efficiency and maximize revenue impact...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$186K - $218K *

Innovate with a collaborative team as you build scalable blockchain infrastructure, design APIs, and streamline complex data processes. Your contributions will enhance system reliability and performan...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$106K - $167K *

Pioneer growth as a Senior Field Sales Executive, driving success in the Eastern US. Manage key accounts, develop strategies, and build relationships to enhance customer satisfaction and achieve sales...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Unlock potential by designing and deploying Power BI solutions that transform data into actionable insights. Collaborate with stakeholders to create scalable models and enhance reporting capabilities...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $185K *

Take ownership of our cloud and backend infrastructure, driving technical direction and improvements. Lead a team to ensure reliability and scalability of systems supporting our games and analytics, w...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$115K - $160K *

Drive your career forward by enabling the Groups team to excel in revenue generation through innovative training, AI-driven tools, and strategic partnerships, ensuring consistent performance and growt...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$200K - $250K *

Elevate the search experience by designing and evolving a robust backend system that powers millions of searches. Collaborate across teams to enhance scalability, reliability, and maintainability whil...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$138K - $219K *

Transform credit strategy by leading complex commercial credit relationships, mentoring junior professionals, and ensuring portfolio health through innovative deal structuring and proactive risk manag...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $180K *

Lead organizational capability by bridging strategy and execution across diverse hospitality operations. Drive scalable frameworks and change management to enhance performance and sustain innovation a...

RemoteRemote

4 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$302K - $483K *

Transform the future of secure platforms by leading engineering strategy and execution. Drive innovation, operational excellence, and team performance to empower autonomy and accountability across the...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$220K - $310K *

Empower businesses by architecting and deploying innovative AI solutions that leverage graph databases and LLMs. Collaborate with stakeholders to transform complex data challenges into impactful appli...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Unlock potential by designing and building robust data pipelines for healthcare transactions. Collaborate with partners to ensure seamless integration and reliability of data systems, enhancing operat...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $140K *

Grow your career with us by leading public safety drone sales in small cities. Own your territory, drive full-cycle deals, and collaborate with cross-functional teams to deliver innovative solutions t...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$152K - $223K *

Drive operational transformation and cloud readiness by leading database modernization initiatives, improving reliability and engineering excellence through automation and best practices while mentori...

RemoteRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Telecommunications & Hardware

$150K - $180K *

Drive strategic planning and operational excellence for a dynamic Marketing & Communications team. Own budgeting, resource management, and cross-functional partnerships while leading initiatives that...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$78K - $108K *

Empower our growth by managing and negotiating sales contracts, collaborating with cross-functional teams to ensure compliance and efficiency. Your expertise will drive impactful solutions in a dynami...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$125K - $160K *

Join a dynamic team as a Sr. Health Benefit Plan Consulting Attorney, leveraging your expertise in healthcare law to navigate complex regulatory issues, support consulting services, and drive complian...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $90K *

Manage and analyze Lost-Time Workers Compensation claims, ensuring timely resolution and adherence to service expectations. Collaborate with clients and stakeholders to deliver innovative solutions in...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$66K - $102K *

Optimize client solutions by leveraging SAP FICO expertise to analyze, design, and implement financial processes. Collaborate with teams to enhance system functionality and ensure seamless integration...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$134K - $249K *

Lead the charge in enhancing clinical systems operations, driving efficiency and effectiveness across pharmacy initiatives while managing a dedicated team and overseeing complex workflows and data int...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Take ownership of key client relationships, driving growth in the renewable energy analytics sector while collaborating across teams to support long-term strategic goals and ensure client success with...

RemoteRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$95K - $133K *

Join a team that's building and leading a high-performing Business Development group. Drive prospecting strategies, enhance team performance, and collaborate with Sales and Marketing to accelerate pip...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.