Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,967

Sort By: Relevance

$145K - $185K *

Champion partner growth by developing and executing multi-tiered GTM strategies, driving revenue expansion across the MSSP and MSP ecosystem while collaborating with sales to enhance market awareness...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$132K - $155K *

Unlock potential by providing advanced technical support and solutions, ensuring exceptional customer experiences. Collaborate with teams to resolve issues, mentor peers, and drive product improvement...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$74K - $130K *

Drive financial excellence by managing program life cycles, collaborating across departments, and ensuring accurate projections and reporting to meet business objectives and mitigate risks...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$215K - $408K *

Drive medical leadership in quality improvement and utilization management, ensuring effective care delivery and cost containment. Collaborate with clinical teams to enhance patient outcomes and suppo...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$145K - $175K *

Champion EPAM's growth by leading Advisor Relations strategy across North America. Build trusted relationships with sourcing advisors to drive commercial opportunities and enhance market perception, a...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$175K - $219K *

Help us elevate Field Medical operations by optimizing processes, enhancing communication, and driving strategic initiatives to ensure effective engagement and alignment across teams in a dynamic heal...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$81K - $91K *

Champion innovative grid modernization solutions by leveraging advanced engineering techniques and collaborating with clients to enhance medium voltage distribution systems. Drive project design, plan...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$123K - $160K *

Join a team that's redefining education by driving state-level approvals for innovative credentials. Collaborate with partners to enhance client confidence and influence revenue growth in high school...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Business Services

$80K - $95K *

Support the design and maintenance of Electrical SCADA Systems, ensuring efficient monitoring and control of electrical power across various sites. Collaborate with engineers and stakeholders to enhan...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$106K - $146K *

Elevate community impact by coaching and mentoring Chapter Executive Directors, enhancing their leadership skills and strategic influence while overseeing a portfolio of five to six Chapters to ensure...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$80K - $90K *

Lead the charge in enhancing professional development for infant and early childhood mental health. Collaborate nationally to deliver high-quality training, support certification, and implement innova...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Shape the future of financial content by crafting engaging, SEO-driven copy that informs and converts. Collaborate with SEO experts and compliance teams to produce clear, compliant content that resona...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $160K *

Lead the charge in driving strategic sales growth within higher education, transforming complex challenges into solutions. Collaborate cross-functionally to enhance market share and establish lasting...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$149K - $198K *

Champion the investigation and diagnosis of complex AV behaviors, driving solutions autonomously across simulation and on-road environments. Utilize Python and custom tools to enhance diagnostic capab...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Transportation

$100K - $104K *

Manage daily property operations, lead a dedicated team, and drive leasing success while ensuring resident satisfaction and financial performance in a dynamic environment...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$125K - $168K *

Pioneer application modernization efforts by leading agile teams, driving technical outcomes, and enhancing developer experiences. Collaborate with clients to deliver measurable business results while...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $200K *

Drive growth by leading strategic partnerships in healthcare tech. Collaborate with executives to shape joint strategies, negotiate impactful deals, and operationalize go-to-market initiatives that en...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Elevate AI experiences from concept to value by collaborating with engineering and design teams. Drive strategy, build prototypes, and make data-driven decisions to enhance user engagement and product...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $200K *

Transform client relationships by driving business growth, securing profitable projects, and leveraging market access expertise. Lead teams to exceed expectations while identifying industry trends and...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$165K - $220K *

Join a team that's redefining avionics systems engineering by translating customer needs into innovative architectures and requirements. Collaborate across domains to deliver high-quality solutions in...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$150K - $180K *

Drive your career with a strategic sales leadership role focused on enterprise growth in healthcare. Lead complex business development efforts, build executive relationships, and shape solutions that...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$130K - $155K *

Lead the AI/ML product strategy across multiple business units, driving integration and data-centric solutions that enhance customer value and revenue growth through innovative workflows and collabora...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $210K *

Lead operational excellence in biopharmaceutical manufacturing, overseeing GMP processes, technology transfers, and clinical supply. Drive strategic initiatives, manage CDMO relationships, and build a...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$106K - $146K *

Shape the future of our operations by leading a dynamic team to optimize Quote-to-Cash strategies, enhance analytics, and design streamlined workflows, all while collaborating across functions to driv...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$280K - $350K *

Unlock potential by leading a high-performing Enterprise sales team to drive revenue growth, mentor talent, and align strategies across departments, ensuring success in complex B2B SaaS solutions for...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.