Explore $100K+ Jobs in Massachusetts

Find professional opportunities in Massachusetts with salaries of $100,000 or more. From Boston and Cambridge to Worcester, Springfield, and other communities, the state offers a varied job market for experienced professionals seeking their next career move. Browse vetted listings on Ladders and explore roles aligned with your skills, experience, and compensation goals.

Discover Opportunities Across Massachusetts

Massachusetts is home to employers in industries including biotechnology, healthcare, finance, technology, higher education, consulting, and advanced manufacturing. Opportunities can range from specialized individual-contributor positions to director, vice president, and executive roles. Availability varies by employer and location, so review each listing for its requirements and work arrangement.

Find Roles That Match Your Experience

Use Ladders to explore high-paying professional jobs and focus your search by title, location, and area of expertise. Review responsibilities and qualifications carefully, then tailor your résumé to highlight relevant achievements, leadership experience, and measurable results.

Build Your Massachusetts Job Search

Whether you are targeting a role in Greater Boston or considering opportunities elsewhere in the state, a focused search can help you identify positions that fit your career priorities. Explore Massachusetts listings on Ladders to take the next step toward a role paying $100,000 or more.

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1,000+

Jobs in Massachusetts

Average Salary in USD

Average Salary: $125,890

Sort By: Relevance

$160K - $190K *

Drive your career forward by leading scientific strategy in precision medicine. Collaborate with biopharma partners to design impactful analyses and insights, while mentoring a team of scientists in a...

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $150K *

Transform patient care by leveraging multimodal AI models in a hands-on role. Collaborate with life sciences to innovate solutions, ensuring regulatory compliance while contributing to impactful resea...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Champion the adoption of MRD testing services by engaging clinicians and stakeholders, driving strategic business development, and maximizing client relationships within major cancer centers and healt...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $220K *

Lead the charge in developing AI-driven healthcare products, overseeing the entire lifecycle from inception to commercialization. Collaborate with Life Sciences partners to align product strategies wi...

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$102K - $134K *

Join a team that's redefining project estimating by leading the preparation of competitive bids and cost analyses for electrical construction projects. Collaborate with estimators and suppliers to ens...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$97K - $156K *

Elevate operational excellence by leading continuous improvement initiatives across manufacturing. Drive performance through Lean, Six Sigma, and project management, fostering a culture of high perfor...

Reposted 3 days ago

  •   8 - 10 years exp.  •   Business Services

$80K - $100K *

Support a diverse team in delivering exceptional field service for high-tech vacuum products. Engage with customers, troubleshoot systems, and ensure operational excellence while traveling for install...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$85K - $115K *

Collaborate with engineers to design and develop advanced vacuum valves, ensuring manufacturability and reliability through all product lifecycle phases. Engage with customers to innovate solutions fo...

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$128K - $225K *

Unlock potential by leading cloud engineering strategy and product development. Oversee a high-performing team to deliver secure, scalable cloud solutions across multiple providers, ensuring alignment...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$71K - $118K *

Advance your career by analyzing and responding to cyber incidents in a dynamic 24x7 Security Operations Center, supporting U.S. State, Local, Tribal, and Territorial governments with critical securit...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$131K - $209K *

Engage with teams to deliver comprehensive AI enablement programs, designing tailored learning paths and fostering a culture of proficiency across all departments. Collaborate closely with HR to integ...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$195K - $220K *

Lead the design and development of cloud-native applications, driving architectural excellence and collaborating with global teams to deliver scalable, secure software solutions while mentoring engine...

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$125K - $150K *

Elevate HR leadership by driving people strategies that enhance organizational effectiveness and employee engagement across multiple locations in the North America Industrial & Construction sector, pa...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Transportation

$135K - $160K *

Lead the charge in building a unified technical organization that enhances customer experience through application support and field service, driving project conversions and fostering a culture of con...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$61K - $104K *

Drive customer success by managing high-value enterprise accounts, ensuring growth and retention through strategic planning and consultative partnerships. Lead renewal efforts and align customer goals...

Boston, MARemote

3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Deliver innovative solutions by leveraging your expertise in project management, collaborating across teams, and driving strategic initiatives to enhance operational efficiency and achieve organizatio...

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$56K - $104K *

Lead the charge in delivering high-quality laboratory services, utilizing advanced technical skills to perform complex assays, ensure accuracy, and collaborate effectively with healthcare professional...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $130K *

Join a dynamic tax team to deliver innovative planning and compliance services. Leverage your expertise in individual and fiduciary taxation while mentoring staff and ensuring client satisfaction in a...

3 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$189K - $255K *

Drive strategic sales initiatives by developing account plans, fostering C-level relationships, and leading negotiations to maximize customer success and revenue growth across a diverse product portfo...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Accelerate client relationships by managing strategic accounts, driving revenue growth, and expanding service lines. Collaborate with internal teams to ensure client satisfaction and deliver tailored...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$125K - $150K *

Accelerate account management strategy and execution for premier accounts. Strengthen relationships through planning, product penetration, and high-quality execution while collaborating across teams t...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$105K - $163K *

Empower AI seeks to optimize ITSM solutions by leading ServiceNow development for a Department of War agency. Drive high-quality, secure applications while enhancing user experience through Agile meth...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $160K *

Unlock potential by leading strategic capture efforts for federal opportunities. Drive business development initiatives, engage with customers and partners, and coordinate cross-functional teams to se...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Business Services

$120K - $130K *

Join our dynamic sales team to drive growth in the rail and transit market. Engage with OEMs and engineering teams, providing tailored connectivity solutions while managing strategic accounts across a...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$90K - $99K *

Elevate your career by shaping complex materials using advanced machinery. Lead a team in a dynamic environment, ensuring precision and quality while exploring innovative technologies and continuous i...

3 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include experienced professional, management, director, vice president, and executive roles across fields such as technology, healthcare, biotechnology, finance, education, and manufacturing. Specific openings and requirements vary.

  • Where in Massachusetts can I find high-paying jobs?question toggle

    Opportunities may be available in Boston, Cambridge, Worcester, Springfield, and other parts of the state. Browse current listings and check each posting for its location and work arrangement.

  • How can I search for Massachusetts jobs paying $100,000 or more?question toggle

    Browse Massachusetts listings on Ladders and refine your search by job title, location, and expertise. Review each posting's compensation information and qualifications.

  • Are Massachusetts jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional job listings. Check the details of each listing to learn about the employer, role, location, compensation, and application requirements.