Find $100K+ Jobs in Massachusetts

Explore professional opportunities across Massachusetts with Ladders. Browse vetted jobs paying $100,000 or more, from roles in Boston and Cambridge to opportunities in Worcester, Springfield, and other communities throughout the state. Whether you’re pursuing your next leadership position or advancing your career in a specialized field, discover openings that match your experience and goals.

Explore Massachusetts Career Opportunities

Massachusetts is home to a diverse economy with employers in technology, healthcare, financial services, education, biotechnology, manufacturing, and professional services. Job availability and compensation vary by employer, role, and experience. Use Ladders to explore current openings and identify opportunities aligned with your skills.

Search by Location and Specialty

Focus your search on major employment centers such as Boston, Cambridge, and Worcester, or look across the state for roles that fit your preferences. Refine your search by job title, industry, seniority, and other relevant criteria to find opportunities suited to your career direction.

Advance Your Career with Ladders

Ladders specializes in vetted professional jobs paying $100,000 or more. Review listings, compare role requirements, and apply to positions that align with your qualifications. Set up a complete profile and keep your resume current to make it easier to pursue your next Massachusetts opportunity.

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1,000+

Jobs in Massachusetts

Average Salary in USD

Average Salary: $125,890

Sort By: Relevance

$143K *

Join a team that's redefining virtual healthcare by delivering high-quality, patient-centered care. As a key member, you'll provide comprehensive virtual medical services, collaborate with stakeholder...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$200K - $250K *

Transform your career by driving new business growth for SMBs through innovative cloud, backup, and disaster recovery solutions. Own your pipeline and strategy while collaborating with a dedicated tea...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$249K - $374K *

Elevate your career by leading clinical development initiatives, designing studies, and collaborating with global teams to shape innovative therapeutic strategies in the Cell Therapy domain...

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$135K - $176K *

Innovate patient care by leading a pharmacy team to enhance service quality, ensure compliance, and foster a culture of excellence. Drive operational efficiency while supporting team development and d...

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$124K - $158K *

Transform patient care by leading pharmacy operations, ensuring safe dispensing, and fostering a culture of excellence. Collaborate with the pharmacy team to enhance patient experiences and support he...

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$132K - $154K *

Elevate customer engagement by leading strategic initiatives in the insurance sector. As a trusted advisor, you'll bridge client needs with platform capabilities, driving revenue and enhancing Solutio...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$186K - $279K *

Elevate clinical development by leading AI strategy and projects across Oncology. Collaborate with cross-functional teams to innovate and implement cutting-edge AI methods, driving measurable advancem...

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$187K - $257K *

Empower transformation initiatives by leading enterprise projects, managing stakeholder relationships, and driving strategic outcomes. Collaborate with diverse teams to define program strategies and e...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Empower transformative telehealth solutions by designing and implementing robust software infrastructure. Join a dynamic team to innovate, automate, and streamline applications, impacting the healthca...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$145K - $185K *

Lead and inspire engineering teams to deliver high-quality digital products, ensuring alignment with business priorities while fostering a culture of collaboration and continuous improvement in a dyna...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Unlock potential by coordinating patient care across the continuum, ensuring optimal health outcomes through effective resource management and compliance with regulatory standards. Collaborate with he...

Today

  •   Less than 5 years exp.  •   Healthcare

$96K - $126K *

Innovate with us to advance bio-analytical assays for cutting-edge DNA therapeutics. Join a dynamic team where your scientific rigor and creativity will drive impactful research in a fast-paced biotec...

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$140K - $180K *

Elevate municipal water projects by leading innovative solutions in drinking water infrastructure. Manage multidisciplinary teams, enhance client relationships, and drive project success from planning...

Today

  •   8 - 10 years exp.  •   Real Estate & Construction

$321K - $500K+*

Shape the future of patient safety in a leading role overseeing benefit-risk strategies, directing high-level governance, and building a world-class safety organization to drive science-based decision...

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$77K - $100K *

Lead culinary operations to enhance patient dining and retail experiences. Drive innovation, team development, and compliance while ensuring exceptional service and satisfaction across diverse culinar...

Today

  •   Less than 5 years exp.  •   Hospitality & Recreation

$287K - $359K *

Drive growth as you cultivate federal accounts, enhance sales strategies, and facilitate large, strategic deals. Leverage your expertise to position mission-critical solutions in a competitive landsca...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$137K - $192K *

Drive the operational execution of complex clinical trials, managing timelines, budgets, and cross-functional teams to ensure efficient study delivery while maintaining compliance with regulations and...

Today

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Drive operational excellence by developing pricing models and analytical tools that enhance visibility into performance metrics. Collaborate with cross-functional teams to align pricing strategies wit...

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $100K *

Transform community connections by engaging directly with customers to promote high-speed telecommunication solutions. Drive sales growth through tailored proposals and exceptional service, while navi...

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$66K - $105K *

Lead the charge in safeguarding corporate data by implementing robust security measures, conducting risk assessments, and collaborating with teams to ensure system integrity and compliance across dive...

Reposted today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$70K - $90K *

Join a team that's shaping the future of government compliance by managing ITSG-33 and FedRAMP authorizations. Collaborate with technical teams to ensure data protection and privacy standards while fa...

Reposted today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Champion your career as a Senior Accountant, overseeing key accounting processes, month-end close, and financial reporting. Collaborate with cross-functional teams to enhance workflows and lead an off...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Media

$232K - $348K *

Drive revenue growth and client engagement in the Mountain States market. Lead proposals, manage key relationships, and execute business strategies to enhance practice presence and deliver high-qualit...

Today

  •   11 - 15 years exp.  •   Finance & Insurance

$140K - $170K *

Transform the future of robotics by developing machine learning systems that empower autonomous robots to perceive and interact with their environment, enhancing efficiency in automated fulfillment op...

Reposted today

  •   Less than 5 years exp.  •   Staffing

$125K - $135K *

Drive the evolution of critical DNS infrastructure, ensuring operational excellence, collaborating across teams, and enhancing production services through automation and API development...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include professional and leadership roles across fields such as technology, healthcare, finance, biotechnology, education, manufacturing, and business services. Available positions change, so browse current listings for the latest opportunities.

  • Where can I find professional jobs in Massachusetts?question toggle

    Search across the state, including major employment centers such as Boston, Cambridge, and Worcester. You can also use location filters to explore roles in other Massachusetts communities.

  • Are the Massachusetts jobs on Ladders vetted?question toggle

    Ladders features vetted professional job listings paying $100,000 or more. Review each listing for details about the employer, responsibilities, qualifications, and compensation.

  • How can I find a Massachusetts job that matches my experience?question toggle

    Use filters such as location, job title, industry, and seniority to narrow your search. Keep your resume current and compare each listing’s requirements with your skills and career goals.