Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Jobs in Iowa

Average Salary in USD

Average Salary: $110,033

Sort By: Relevance

$181K - $266K *

Accelerate global market access strategies for a transformative gene therapy portfolio. Lead cross-functional teams to ensure timely patient access while shaping payer policies and maintaining pricing...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$118K - $190K *

Lead the charge in delivering innovative solutions by managing complex technical projects. Collaborate with cross-functional teams to ensure successful implementation while promoting best practices an...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $115K *

Bring your expertise to drive new business growth by selling innovative solutions in a consultative manner. Manage the full sales cycle while building lasting relationships with enterprise-level clien...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Elevate software solutions by designing and developing applications that enhance genetic testing workflows. Collaborate with cross-functional teams to ensure reliability and efficiency in clinical dia...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $220K *

Lead successful outcomes across complex technology programs and large-scale customer environments. Drive governance, manage risks, and facilitate executive relationships while coordinating multiple cr...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Lead the charge in building and delivering high-quality software features, overseeing architecture, design, and implementation while collaborating with cross-functional teams to ensure readiness and m...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $184K *

Lead the charge in enhancing platform security and infrastructure as a Senior Software Engineer. Utilize your Python expertise and SRE mindset to drive critical improvements, mentor teammates, and ens...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Join a team that's driving sales excellence in the Workday ecosystem. Leverage your expertise to build relationships, create strategies, and maximize ROI for clients while managing a large geographica...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Lead a dynamic sales team to drive growth in the oncology market. Foster relationships, develop strategies, and ensure execution of corporate initiatives while mentoring account managers and specialis...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$146K - $180K *

Advance your career by leading innovative bioinformatics projects focused on machine learning for early cancer detection. Collaborate with experts to develop cutting-edge methods and mentor a dynamic...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $157K *

Champion data governance and integrity in a global EPM environment. Lead operational execution, ensure compliance, and drive continuous improvements while collaborating with finance and IT stakeholder...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$170K - $200K *

Engineer scalable Salesforce architectures, ensuring alignment with business goals and best practices. Lead complex initiatives, mentor teams, and drive integration strategies across systems to enhanc...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Business Services

$161K - $258K *

Shape the future of national security policy by leading strategic government engagement, assessing risks, and advocating for impactful telecommunications initiatives that drive global operations and m...

RemoteRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$80K - $95K *

Empower the CEO by managing their calendar, prioritizing engagements, and ensuring seamless communication across teams. This role requires strategic thinking and proactive problem-solving to support l...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Elevate client operations by implementing and managing Procore solutions, ensuring seamless project management and integration. Collaborate with stakeholders to enhance software adoption and deliver e...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$54K - $159K *

Lead the charge in integrating CAM capabilities across diverse business lines. Collaborate with cross-functional teams to ensure effective implementation and operational success, driving alignment on...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$67K - $100K *

Champion system support and configuration for Production Operations and Sales systems, enhancing user experience and driving process improvements. Collaborate with teams to troubleshoot issues and imp...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Join a dynamic litigation practice group, handling diverse cases including medical negligence and insurance disputes. Ideal for self-starters eager to grow in a supportive environment with potential f...

2 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$125K - $175K *

Engage in a pivotal role overseeing project delivery excellence, guiding project managers to enhance financial performance and mitigate risks across a diverse portfolio while fostering professional de...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$120K - $145K *

Elevate your career by developing scalable software solutions for IoT systems. Collaborate with cross-functional teams to enhance infrastructure that detects electrical fire risks, making a significan...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$88K - $163K *

Champion a strategic approach to outbound sales by optimizing contact lists, analyzing data, and enhancing team performance across regions. Drive effective targeting and ensure reps maximize their out...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$101K - $125K *

Innovate power systems engineering by leading studies, enhancing models, and training teams. Collaborate on projects involving renewable resources and grid modernization, ensuring quality and efficien...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$180K - $220K *

Unlock the potential of consumer experiences by owning the discovery surfaces that connect eaters with their meals. Collaborate with cross-functional teams to enhance user engagement and drive impactf...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Food & Beverages

$92K - $114K *

Engineer scalable application solutions by leading complex development projects, ensuring code quality, and guiding best practices. Collaborate with teams to resolve advanced issues and align with ent...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$136K - $187K *

Transform financial operations by leading a global accounting team, enhancing workflows, and driving automation. Collaborate across departments to ensure compliance and efficiency while managing criti...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.