Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Jobs in Iowa

Average Salary in USD

Average Salary: $110,033

Sort By: Relevance

$120K - $160K *

Join a team that's redefining integrated marketing strategies, leading cross-channel campaigns that drive product narratives and customer engagement. Shape the future of marketing through collaboratio...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$124K - $224K *

Unlock potential by leading revenue operations, bridging sales, finance, and analytics. Drive forecasting, pipeline management, and team development to enhance business performance and ensure data int...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$151K - $248K *

Unlock your potential by driving product innovation and cross-functional alignment in a dynamic environment. Lead initiatives that shape lending solutions, enhance decision-making, and deliver impactf...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$115K - $140K *

Empower your career by driving sales in a dynamic environment. As an Account Manager, leverage your expertise to promote our psychiatry portfolio, navigate market complexities, and build strong relati...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $171K *

Join a team that's redefining integrated technology solutions, providing enterprise-level systems engineering leadership to drive scalable, reliable, and innovative solutions across diverse product po...

1 week ago

  •   11 - 15 years exp.  •   Transportation

$110K - $130K *

Champion your career by leading security engagements, assessing architectures, and enhancing compliance. Collaborate with top professionals to identify risks and implement best practices, ensuring rob...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$139K - $235K *

Transform compensation strategies by leading program design and execution. Collaborate with cross-functional teams to ensure compliance, enhance processes, and deliver accurate outcomes that attract a...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$300K - $350K *

Join a team that's driving sales growth in the cybersecurity sector. This role focuses on acquiring new accounts, building customer relationships, and ensuring satisfaction while exceeding sales quota...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Join a team that's dedicated to enhancing information security through proactive assessments and innovative solutions. Contribute to compliance and risk management while implementing best practices in...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$128K - $142K *

Lead the charge in managing construction sprinkler projects, overseeing sales and project teams while ensuring financial success and exceptional customer service across Eastern Iowa and Western Illino...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$85K - $116K *

Manage and support a complex network environment, ensuring reliability and security. Provide real-time operational support, troubleshoot issues, and coordinate with teams to maintain and enhance netwo...

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$110K - $130K *

Unlock potential by leading strategic digital transformation sales across industries. Drive complex pursuits integrating Cybersecurity, AI solutions, and Manufacturing Operations Management to enhance...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Join us to lead transformational sales in digital operations, driving complex solutions across cybersecurity and manufacturing. Collaborate with stakeholders to unlock value and accelerate customer ou...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$156K - $212K *

Accelerate progress at the forefront of medical science, engaging with healthcare leaders to enhance patient outcomes through strategic scientific communication and collaboration in rare diseases and...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$104K - $141K *

Lead the charge in transforming Human Genetics strategy into actionable plans, ensuring measurable progress across R&D. Collaborate with cross-functional teams to align priorities and drive successful...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Accelerate progress at the forefront of rare disease management by collaborating with key stakeholders to enhance patient access and streamline treatment pathways across health systems and specialty c...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$144K - $194K *

Accelerate progress at the forefront of oncology marketing by leading global initiatives, synthesizing insights, and driving execution across teams to enhance product strategies and launch readiness...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$155K - $210K *

Shape the future of regulatory policy by leading initiatives that influence key decisions and drive alignment across teams. Collaborate with stakeholders to advocate for impactful policies that suppor...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$193K - $262K *

Lead and optimize field effectiveness initiatives, driving sales performance through insights and operational excellence. Manage a high-performing team while collaborating cross-functionally to enhanc...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$204K - $276K *

Lead the charge in global observational research, driving clinical operational strategy and execution. Collaborate with cross-functional teams to ensure quality and efficiency in evidence generation t...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Champion strategic workforce planning and AI-driven work design to enhance capability, improve productivity, and advance internal mobility across teams. Drive tools and strategies aligning workforce p...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$285K - $385K *

Lead regulatory due diligence for clinical/commercial assets, assessing risks and strategies for licensing, acquisitions, and partnerships. Collaborate across teams to ensure regulatory integration in...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$189K - $246K *

Lead clinical pharmacology strategies, integrating PK/PD assessments across development phases. Collaborate with cross-functional teams to guide decision-making and regulatory submissions, ensuring al...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$145K - $220K *

Shape the future of Finance by managing AI transformation initiatives, collaborating with stakeholders to identify high-value use cases, and ensuring successful integration of AI solutions within Fina...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$121K - $170K *

Lead the transformation of storage solutions by leveraging deep technical expertise in NetApp Keystone and Storage-as-a-Service. Collaborate with customers to architect tailored solutions that optimiz...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.