Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Jobs in Iowa

Average Salary in USD

Average Salary: $110,033

Sort By: Relevance

$138K - $165K *

Transform AI capabilities by building robust SDKs and infrastructure. Collaborate with product teams to enhance agent workflows, ensuring reliability and performance while driving innovation in AI exp...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$297K - $367K *

Grow your career with a pivotal role driving hospital data integration and compliance. Lead execution of clinical data operations, build relationships, and ensure secure data handling while shaping a...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Join a team that's redefining financing experiences by leading product strategy and execution for Originations. Drive growth through innovative apply and checkout solutions while collaborating across...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$127K - $224K *

Drive impactful product modeling and marketing measurement as a Staff Data Scientist. Own the lifecycle of ML models, collaborate with PMs, and communicate insights effectively to enhance user experie...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$96K - $169K *

Engineer robust Salesforce applications and integrations, driving full-lifecycle development from design to deployment. Collaborate with cross-functional teams to enhance sales and service tools, ensu...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$83K - $147K *

Join a team that's shaping the future of sales training by architecting and delivering innovative programs for agents. Collaborate with leaders to enhance strategies, improve performance, and drive ex...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$165K - $292K *

Shape the future of user experience by leading design across multiple products. In this strategic role, you will influence a team of designers, drive innovative product development, and elevate design...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$147K - $293K *

Lead the charge in building delightful digital experiences for life insurance consumers, advocating user needs while driving strong business growth through innovative product management and data-drive...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$123K - $217K *

Drive your career with impactful cross-functional programs, leading initiatives from planning to launch. Collaborate with diverse teams to navigate complexity, ensuring successful delivery and continu...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$139K - $235K *

Lead the development of innovative CX solutions using AI tools, enhancing workflows and integrations across platforms. Collaborate with cross-functional teams to deliver production-quality software an...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$183K - $323K *

Lead design initiatives to transform user journeys into intuitive experiences ensuring clarity, engagement, and conversion. Collaborate across teams to elevate design excellence and mentor talented de...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$215K - $307K *

Lead the charge in designing and evolving global cloud infrastructure, leveraging deep Azure expertise to build secure, scalable systems that enhance enterprise SaaS platforms and improve developer ex...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$160K - $200K *

Join a team that's redefining cloud operations by leading a unified infrastructure organization. Drive platform reliability, cost efficiency, and operational excellence while collaborating with cross...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$215K - $408K *

Drive medical management and quality improvement initiatives, ensuring effective utilization and cost containment while collaborating with clinical teams to enhance patient care and outcomes across mu...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Inspire growth by driving enterprise partnerships in healthcare. Leverage your sales expertise to lead complex cycles, build relationships with C-suite stakeholders, and shape strategic initiatives in...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $150K *

Accelerate progress at building trades by cultivating relationships with contractors, generating leads, and collaborating with sales teams to enhance customer experiences and represent the brand at in...

6 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$120K - $145K *

Lead and develop dynamic engineering teams to enhance communication systems that improve health equity outcomes for underserved patients. Drive technical direction, manage shared codebases, and collab...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Lead the charge in executing capital projects, overseeing design to startup, and ensuring engineering standards are met while managing budgets and schedules for small to medium-sized initiatives...

6 days ago

  •   Less than 5 years exp.  •   Staffing

$110K - $130K *

Lead the charge in implementing enterprise software solutions in healthcare, coordinating cross-functional teams to ensure compliance with financial and PCI standards while driving project success and...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Grow your career with a dynamic role focused on expanding strategic accounts in healthcare. Drive sales, enhance customer relationships, and lead initiatives to meet objectives while collaborating wit...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$110K *

Champion marketing analytics to drive insights and improve enrollment performance. Collaborate with teams to evaluate marketing effectiveness, optimize strategies, and enhance decision-making through...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$125K - $150K *

Accelerate growth by leading innovative marketing strategies that drive customer expansion and partner engagement. Collaborate cross-functionally to create data-driven campaigns that enhance retention...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$118K - $216K *

Lead the development of innovative ad solutions for a high-traffic mobile app, enhancing user experience while driving revenue. Collaborate with cross-functional teams to implement AI-driven workflows...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $90K *

Manage board relations and special projects, ensuring effective communication and support for the Executive Director. Collaborate across teams to execute organizational priorities and enhance governan...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$81K - $129K *

Partner with us to drive project excellence across the Americas by managing upgrade planning and costing, ensuring high standards in productivity, customer satisfaction, and operational metrics throug...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.