Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Jobs in Iowa

Average Salary in USD

Average Salary: $110,075

Sort By: Relevance

$120K - $150K *

Lead the charge in operational oversight of clinical laboratory services, ensuring compliance with regulatory standards while promoting high-quality, cost-effective testing. Collaborate with healthcar...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$92K - $160K *

Engage with local agencies to drive revenue growth through strategic partnerships. Leverage your expertise in digital sales and agency relations to cultivate relationships, exceed sales targets, and r...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Media

$120K - $220K *

Join a team that's shaping the future of Dynamics 365 solutions by providing technical leadership and architectural guidance. Collaborate with cross-functional teams to design, implement, and enhance...

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Create reliable backend systems and tools that empower engineers, ensuring seamless integration and performance across platforms while enhancing developer experience and operational efficiency...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$171K - $269K *

Engineer cutting-edge machine learning algorithms and models, collaborating across teams to integrate AI functionalities into products. Drive innovation and ensure AI's transformative potential is rea...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$178K - $232K *

Innovate by developing cutting-edge machine learning algorithms and models. Collaborate with cross-functional teams to enhance AI functionalities across products, driving impactful solutions and impro...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Lead the configuration and support of Epic applications, ensuring seamless integration and optimal performance. Collaborate with teams to enhance workflows, troubleshoot issues, and drive project succ...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Lead EMR strategy and manage vendor relationships to drive operational excellence. Oversee the EMR Solution Specialist team, ensuring compliance and quality in system procedures while enhancing EMR su...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$137K - $182K *

Lead the charge in transforming customer experience analytics by partnering with CX leadership to develop actionable insights, scalable reporting, and strategic analytics solutions that drive business...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$99K - $129K *

Drive operational reliability for critical financial systems, enhancing automation and infrastructure across multiple Scrum teams. Collaborate to ensure seamless processing and support business growth...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Lead the strategy and development of digital publishing products, enhancing workflows and user experiences. Collaborate across teams to create a cohesive ecosystem that supports efficient content mana...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Food & Beverages

$93K - $150K *

Empower operational excellence by leading pilot implementations, engaging with customers, and translating insights into scalable solutions. Drive measurable outcomes while navigating complex environme...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Innovate healthcare solutions by leading product strategy for health plans. Collaborate with executives to design competitive offerings, ensuring alignment with market needs and operational execution...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Business Services

$101K - $126K *

Drive clinical excellence by managing Prior Authorizations and Drug Utilization Reviews. Collaborate with healthcare providers to enhance patient care and optimize therapeutic interventions while ensu...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$79K - $98K *

Join us to lead product management for our Medicare Part D program, ensuring compliance with CMS regulations while enhancing processes and client satisfaction. Your expertise will drive operational ex...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Elevate member health through tele-pharmacy by developing clinical programs, providing outreach, and collaborating with healthcare teams to enhance care coordination and adherence to medication guidel...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$135K - $216K *

Shape the future of air traffic management by integrating modern display technology for the FAA. Collaborate with experts to enhance safety and efficiency in the National Airspace System through innov...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Aerospace & Defense

$135K - $216K *

Drive the modernization of air traffic management systems by integrating data and display technologies. Collaborate with FAA teams to enhance safety and efficiency in the National Airspace System thro...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Aerospace & Defense

$135K - $216K *

Partner with us to enhance the National Airspace System by ensuring timely upgrades and installations. Collaborate with FAA and vendors to implement cutting-edge technology, ensuring safety and effici...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Aerospace & Defense

$66K - $106K *

Transform organizational communications by crafting clear, concise technical documents and managing SharePoint resources. Collaborate with teams to ensure quality and consistency in messaging while su...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Aerospace & Defense

$104K - $166K *

Shape the future of database management by supporting and enhancing DB2 environments. Leverage your expertise in administration, troubleshooting, and SQL development to ensure optimal performance acro...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Aerospace & Defense

$220K - $245K *

Tackle financial strategy and analysis for a leading Wellbeing business. Collaborate with leadership to enhance member engagement and operational efficiency, driving growth through insightful financia...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$165K - $210K *

Transform retail sales strategies and lead a dynamic team to achieve revenue goals. Drive account management, develop talent, and collaborate with cross-functional teams to enhance product offerings a...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Consumer Technology

$61K - $119K *

Join a team that's dedicated to empowering clients through personalized financial planning. As a financial advisor, you'll build relationships, create tailored strategies, and drive your entrepreneuri...

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$180K - $207K *

Innovate AI and ML systems as a Principal Architect, collaborating with teams to design agentic architectures and scalable solutions. Drive production delivery while shaping standards and best practic...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.