Find high-paying career opportunities across Illinois with Ladders. Browse vetted professional jobs offering salaries of $100,000 or more, from openings in Chicago to roles in cities and communities throughout the state. Whether you’re ready to take the next step in your career or explore a new industry, discover Illinois positions that match your experience and goals.
Illinois offers a broad range of professional opportunities, with a concentration of employers and roles in the Chicago area and opportunities across the rest of the state. Explore positions in fields such as finance, technology, healthcare, manufacturing, consulting, and business leadership. Available roles and compensation vary by employer, location, and experience.
Use Ladders to explore professional openings with salaries of $100,000 or more. Review job details, compare opportunities, and focus your search on the locations, industries, and responsibilities that align with your career plans. Check listings for requirements, work arrangements, and compensation details.
Start your search for a high-paying job in Illinois by browsing current listings and applying to roles that fit your qualifications. New opportunities can become available over time, so check back regularly to find the latest vetted professional jobs on Ladders.
Average Salary: $117,836
Staff/Principal AI Scientist - Virtual Tissue
$150K - $180K *
Engineer advanced protein design models and collaborate with experts to innovate in AI Drug Discovery, driving the development of candidate antibody therapeutics through deep learning and systems biol...
Reposted 6 days ago
$102K - $170K *
Accelerate progress at transforming data solutions by building production-grade assets. Leverage your expertise in data engineering and business fluency to create trusted, reusable data products that...
6 days ago
Database Support Engineer (US East)
$150K - $200K *
Shape the future of data solutions as a Database Support Engineer, driving customer success through onboarding, technical support, and collaboration with sales teams to enhance product adoption and op...
6 days ago
$150K - $251K *
Pioneer innovative technology strategies and architectural solutions across Agile teams, driving AI-enabled engineering transformation and ensuring scalable, secure, and maintainable solutions for ent...
6 days ago
$118K - $135K *
Engage customers and drive renewal success by managing a portfolio, reinforcing value, and leading negotiations. Collaborate cross-functionally to mitigate risks and ensure a positive customer experie...
6 days ago
Benefits Analyst, North America
$68K - $102K *
Drive your career with a dynamic role in global benefits administration, ensuring compliance and enhancing employee wellness programs. Collaborate with vendors and support Total Rewards initiatives wh...
Reposted 6 days ago
$115K - $130K *
Lead the charge in optimizing search channels for diverse clients, managing a global team while driving SEO, PPC, GEO, and AIO strategies. Ensure performance efficiency and deliver insightful reportin...
6 days ago
Manager, Inventory Optimization & Advanced Analytics
$112K - $188K *
Join us to lead inventory optimization initiatives that enhance customer solutions through advanced analytics and strategic planning, partnering with cross-functional teams to drive operational effici...
Reposted 6 days ago
LICENSE PENDING REGISTERED NURSE- 2ND MEDICAL
$71K - $94K *
Join a team that's dedicated to delivering compassionate care in a fast-paced medical environment. As a License Pending RN, you'll assess, plan, and implement patient care while collaborating with hea...
6 days ago
Manager, Global Network Design & Optimization
$112K - $188K *
Optimize your career by leveraging advanced analytics and modeling to enhance supply chain network design. Lead cross-functional projects, influence strategic decisions, and mentor team members in a h...
Reposted 6 days ago
$210K - $250K *
Innovate in AI-native primary care by leading a dynamic medical group. Manage physicians, enhance care delivery, and shape clinical programs while maintaining direct patient care involvement. Drive ex...
6 days ago
$210K *
Lead the charge in managing IT projects for our enterprise payments ecosystem. Collaborate with technical teams to develop detailed project plans, ensuring successful execution and alignment with busi...
6 days ago
$94K - $118K *
Unlock your potential by managing a comprehensive benefits program, ensuring compliance, and enhancing employee experience. Collaborate with cross-functional teams to streamline operations and support...
6 days ago
Professional Liability Underwriting Lead
$200K - $240K *
Pioneer the development of a new Professional Liability product, focusing on E&O and MPL. Lead underwriting strategy, drive profitable growth, and leverage technology to enhance client-centric process...
6 days ago
Professional Liability Underwriting Lead
$200K - $240K *
Transform the future of commercial insurance by leading the development of a new Professional Liability product. Drive strategy, build broker relationships, and ensure profitable growth while collabor...
6 days ago
Sr. CRA, FSP - Surgical / Medical Device - Central region
$130K - $133K *
Advance clinical research by leading site monitoring and management efforts. Ensure compliance with regulatory standards while overseeing study protocols and data integrity. Collaborate with teams to...
6 days ago
RN Navigator - Oncology (Methodist)
$72K - $118K *
Optimize patient care by guiding individuals through the cancer treatment journey. Collaborate with healthcare teams to ensure timely access to resources, education, and support, enhancing patient sat...
6 days ago
$125K - $150K *
Lead treasury operations and investment strategies, ensuring compliance and optimizing cash flow. Collaborate with senior leadership to enhance financial planning and reporting, while managing a subst...
6 days ago
$85K - $97K *
Join a dynamic team to manage billing processes, ensuring accuracy and compliance while collaborating with attorneys and clients. Drive efficiency in billing operations and enhance client service thro...
6 days ago
Lead Information Systems Security Officer (ISSO) - Post-Quantum Cryptography
$105K - $155K *
Join a team that's dedicated to safeguarding critical systems through expert security management. Leverage your RMF knowledge to ensure compliance, drive remediation, and maintain robust security post...
Reposted 6 days ago
Principal Experience Designer - Visual Design & Design Systems
$190K - $315K *
Shape the future of visual design for an enterprise design system, leading the evolution of its visual language and guiding teams to create consistent, high-quality experiences across products and maj...
6 days ago
Founding Forward Deployed Engineer
$125K - $150K *
Unlock potential by leading the development of innovative AI solutions that transform complex learning workflows into impactful autonomous agents, collaborating closely with strategic clients to shape...
6 days ago
Staff Attack Engineer, External
$238K - $280K *
Lead the charge in developing autonomous attack workflows for external surfaces, leveraging your expertise to enhance reconnaissance capabilities and mentor engineers while driving strategic technical...
6 days ago
Senior Attack Engineer, External
$206K - $242K *
Transform external attack capabilities by developing scalable workflows and automating reconnaissance processes. Drive innovation in offensive security, mentor teammates, and contribute to a high-impa...
6 days ago
Mid-Enterprise Account Executive, East Coast
$200K - $250K *
Empower growth in the cybersecurity sector by driving sales, acquiring new accounts, and fostering strong customer relationships. Leverage your expertise to introduce innovative solutions and exceed s...
6 days ago
What types of $100,000+ jobs can I find in Illinois?
Illinois listings may include professional and leadership roles in areas such as finance, technology, healthcare, manufacturing, consulting, and business operations. Job availability and qualifications vary by employer.
Are there high-paying jobs outside Chicago?
Yes. While many opportunities are based in the Chicago area, listings may also be available in other Illinois cities and communities. Search by location to explore current openings.
How can I find Illinois jobs that pay $100,000 or more?
Browse Illinois listings on Ladders and review each job’s salary information, qualifications, location, and work arrangement. Listings feature vetted professional opportunities with salaries of $100,000 or more.
Do Illinois job listings include remote or hybrid roles?
Some listings may offer remote or hybrid work, depending on the employer and position. Check each job description for the specific work arrangement.