Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$128K - $176K *
Transform complex clinical and regulatory documents into clear, compliant submissions. Collaborate with teams to ensure accuracy and adherence to standards while managing multiple projects in a fast-p...
2 weeks ago
Medical Science Liaison, Southeast (Multiple Territories)
$155K - $175K *
Develop trusted relationships with key stakeholders, delivering scientific insights and supporting prelaunch activities. Operate independently in a dynamic environment, influencing adoption through cr...
2 weeks ago
Senior Director, Head of Analytical Development
$250K - $275K *
Transform the future of drug development by leading Analytical Development for small molecules and oligonucleotides. Drive scientific strategy, build a high-performing team, and ensure regulatory read...
2 weeks ago
Medical Science Liaison, Northeast (Multiple Territories)
$155K - $175K *
Serve as a key scientific partner in the field, driving prelaunch and launch strategies through trusted relationships, high-quality exchanges, and actionable insights to enhance product adoption and c...
2 weeks ago
Forward Deployed Process Consultant- R37
$113K - $226K *
Lead the charge in optimizing healthcare processes by bridging strategy and execution. Collaborate with teams to enhance coding workflows, drive change management, and ensure alignment with strategic...
2 weeks ago
CT (Computerized Tomography) Installation Engineer - Remote/Travel/Field
$74K - $102K *
Advance your career by providing expert installation support for CT systems, ensuring quality and timely project completion while collaborating with vendors and stakeholders. Travel required for custo...
2 weeks ago
CT (Computerized Tomography) Installation Engineer - Remote/Travel/Field
$74K - $102K *
Drive the charge in expert CT installations, ensuring quality and timely project completion while providing top-tier support and troubleshooting for field service teams and vendors...
2 weeks ago
Director of Operations, ES, North Carolina
$143K - $196K *
Elevate healthcare delivery by leading strategic partnerships and enhancing operational performance. Collaborate across teams to drive exceptional customer engagement and ensure alignment with clinica...
2 weeks ago
Director of Operations, ES - Tampa, FL
$143K - $196K *
Elevate healthcare delivery by leading strategic partnerships and optimizing operations within Oncology service lines. Drive performance through exceptional customer engagement and collaboration acros...
2 weeks ago
Manager Enterprise Authorization Services
$80K - $95K *
Drive the success of insurance prior authorization processes by leading a team of specialists. Ensure timely approvals and minimize payment denials through effective management, communication, and pro...
2 weeks ago
Nurse Practitioner | Avera at Home
$92K - $110K *
Provide comprehensive medical care by assessing and treating patients, collaborating with physicians, and ensuring quality health education. Contribute to patient safety and care standards while maint...
2 weeks ago
Senior Site Identification Analyst (Contractor)
$100K - $120K *
Join a team that's dedicated to enhancing clinical operations through strategic site identification and management. Leverage your expertise to build relationships, track project timelines, and contrib...
2 weeks ago
$136K - $204K *
Champion impactful scientific dialogue with key healthcare leaders in Cardiology, promoting evidence-based practices and insights. Collaborate cross-functionally to enhance clinical decision-making an...
Reposted 2 weeks ago
Clinical Application Support Specialist II- RO
$70K - $105K *
Unlock potential by providing exceptional support and training in clinical software, ensuring customer satisfaction through effective communication and problem-solving in a fast-paced environment. Joi...
2 weeks ago
$73K - $109K *
Drive your career with impactful service as you troubleshoot and maintain advanced medical equipment, ensuring optimal performance and customer satisfaction across the Pacific Region, with a focus on...
2 weeks ago
$96K - $144K *
Lead the charge in delivering exceptional customer service and technical support at assigned medical equipment sites, ensuring compliance with contracts and fostering strong client relationships throu...
2 weeks ago
$110K - $130K *
Transform patient care by engaging with Cardiology KOLs as a medical liaison, fostering scientific dialogue, and mentoring teams in advancing innovative healthcare strategies. Drive educational initia...
Reposted 2 weeks ago
Biomedical Equipment Technician 2
$71K - $107K *
Drive customer satisfaction by evaluating and repairing complex biomedical equipment. Collaborate with teams to ensure effective service delivery and maintain compliance with safety standards while en...
2 weeks ago
Epic Professional Billing Analyst 2
$70K - $100K *
Join a team that's dedicated to optimizing Epic Resolute Professional Billing. Support daily operations, troubleshoot issues, and enhance workflows while collaborating with analysts and users to ensur...
2 weeks ago
Physical Therapist Traveler - Nationwide
$87K - $100K *
Transform your career as a Full-Time Internal Traveler, delivering expert physical therapy across diverse clinics nationwide while enjoying the stability of full-time employment and comprehensive bene...
2 weeks ago
Revenue Cycle Managed Services - Utilization Management (UM) / Utilization Review (UR) Lead
$110K - $130K *
Lead the charge in optimizing utilization management operations, enhancing efficiency, and driving performance improvements. Collaborate with clinical and operational teams to ensure timely reviews an...
2 weeks ago
Medical Science Liaison, West (Multiple Territories)
$155K - $175K *
Champion the field as a Medical Science Liaison, driving prelaunch strategies and fostering relationships with key stakeholders. Leverage clinical insights to educate and influence healthcare professi...
2 weeks ago
$80K - $95K *
Champion the success of a dynamic lab team by overseeing daily operations, ensuring compliance, and driving performance. Collaborate across departments to enhance processes and maintain high-quality s...
2 weeks ago
Director/Sr. Director, Patient Support Programs
$150K - $180K *
Join a team that's dedicated to enhancing patient access through strategic design and management of support programs. Oversee vendor relationships and ensure compliance while driving initiatives that...
2 weeks ago
Manager of Insurance Verification & Authorizations
$101K - $146K *
Elevate the insurance verification and authorization process by managing staff, developing strategies, and ensuring excellent service delivery while resolving complex patient financial needs in a coll...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.