Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Certified Anesthesiologist Assistant
$100K - $120K *
Join a team that's dedicated to providing exceptional anesthetic care in a Level II Trauma Center. Engage in diverse procedures and enjoy a supportive work environment with opportunities for professio...
3 weeks ago
Certified Anesthesiologist Assistant
$100K - $120K *
Unlock potential by joining a dynamic anesthesia team at a Level II Trauma Center, where you'll practice diverse techniques and collaborate closely with anesthesiologists to ensure safe, effective pat...
3 weeks ago
$250K - $300K *
Join a dedicated team to assess, diagnose, and treat patients, ensuring quality care and health education. Collaborate with healthcare professionals to enhance patient outcomes and maintain accurate m...
Yesterday
$80K - $95K *
Unlock potential by leading compliance audits, ensuring accurate coding and documentation in anesthesia. Collaborate with teams to mitigate risks, deliver training, and maintain regulatory standards w...
Today
$150K - $180K *
Join a pioneering team to build an AI-enabled care delivery platform, bridging clinical expertise and engineering to create safe, effective patient care solutions. Drive innovation from concept to pro...
3 weeks ago
Analyst - Information Technology
$66K - $113K *
Champion enterprise portfolio reporting and analytics, developing insights to drive strategic decision-making and enhance project visibility. Collaborate across teams to create actionable dashboards a...
4 weeks ago
Medical Director - Critical Care
$300K - $309K *
Transform patient care by leading medical strategy and clinical innovation. As a vital member of the team, you'll guide product development and trial execution while engaging with key stakeholders to...
Reposted 3 weeks ago
$210K - $250K *
Deliver comprehensive case reviews and clinical guidance, ensuring regulatory compliance and optimal patient outcomes. Collaborate with healthcare teams across multiple states to enhance service quali...
3 weeks ago
Senior Manager - Automation - RCM
$89K - $151K *
Deliver exceptional automation solutions that enhance operational efficiency and accuracy across the healthcare revenue cycle. Lead strategic initiatives to streamline processes, optimize performance...
4 weeks ago
$262K - $404K *
Optimize patient care and operational leadership as you manage Anesthesia APP teams, ensure regulatory compliance, and build strong client relationships while driving growth in practices and enhancing...
4 weeks ago
Physician | Neurosurgery Inpatient Only
$280K - $350K *
Lead the charge in providing exceptional medical care and patient education. Collaborate with a dedicated team to assess, diagnose, and treat patients, ensuring adherence to safety standards and quali...
1 week ago
$180K - $220K *
Join a team that's dedicated to transforming patient care through a Whole Health System, managing inpatient medical cases, and collaborating with healthcare professionals to enhance the well-being of...
Yesterday
Certified Registered Nurse Anesthetist | Rapid City Hospital
$160K - $190K *
Shape the future of anesthetic care by collaborating with a dedicated team to provide safe, patient-focused services. Your expertise will drive quality outcomes in a supportive environment that champi...
Reposted today
$120K - $250K *
Transform clinical trials by ensuring patient safety and scientific integrity. Collaborate with stakeholders to uphold regulatory standards and optimize study protocols, while providing expert medical...
2 weeks ago
$198K - $297K *
Engage in a dynamic role that empowers team collaboration and drives results in a leading organization recognized for innovation and excellence in performance, fostering an environment of growth and p...
Reposted 2 weeks ago
Physician (Diagnostic Radiologist)
$210K - $250K *
Empower patient care through expert image interpretation and guidance in diagnostic radiology. Collaborate on quality assurance, oversee technical standards, and educate staff while ensuring optimal p...
3 days ago
Solutions Architect (Contract)
$156K - $187K *
Transform the data landscape by designing and implementing robust integration solutions. Collaborate with cross-functional teams to enhance analytics infrastructure, ensuring seamless data flow and go...
3 weeks ago
$160K - $200K *
Elevate patient care by administering anesthesia and collaborating with healthcare teams. Develop pre-anesthetic plans, monitor patients, and ensure safety during procedures while communicating effect...
5 days ago
$160K - $200K *
Administer anesthesia and sedation for diverse procedures, develop pre-anesthetic plans, collaborate with healthcare teams, and monitor patient responses to ensure optimal care and safety throughout s...
5 days ago
$170K - $200K *
Unlock your potential in a dynamic anesthesia role, collaborating with a skilled team to deliver exceptional patient care. Enjoy a balanced schedule with generous time off while managing diverse surgi...
2 weeks ago
$110K - $130K *
Join a team that's dedicated to creating impactful medical education content for healthcare providers and patients. Collaborate closely with scientific and account teams to deliver high-quality materi...
Reposted yesterday
$180K - $220K *
Shape the future of compassionate care by leading a multidisciplinary team to enhance the quality of life for patients in their final stages, ensuring comfort, dignity, and emotional support through p...
1 week ago
$210K - $250K *
Transform patient care by providing comprehensive medical evaluations, diagnoses, and treatments. Collaborate with healthcare teams to enhance health education and ensure quality care while adhering t...
6 days ago
$210K - $250K *
Join a dedicated team providing comprehensive medical care and education to patients. Assess, diagnose, and treat with a focus on quality and safety, while collaborating with healthcare professionals...
6 days ago
$80K - $95K *
Empower healthcare technology by enhancing clinical systems and integrations. Collaborate with IT and business stakeholders to optimize workflows, manage projects, and ensure system performance across...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.