Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$140K - $190K *
Unlock your potential by engaging key Gastroenterology stakeholders, driving product utilization, and exceeding sales goals through strategic collaboration and compliance in a dynamic healthcare envir...
4 weeks ago
Medical Director, Gastroenterology
$210K - $250K *
Unlock potential by leveraging your GI expertise to enhance product development, strengthen customer relationships, and drive growth in a dynamic SaaS environment. Collaborate across teams to deliver...
1 week ago
Medical Monitor (US Board-Certified Gastroenterologist)
$210K - $250K *
Innovate with us to enhance patient safety in global clinical studies. As a key medical expert, you'll provide critical input, oversee trial safety, and collaborate with teams to ensure compliance and...
2 weeks ago
Specialty Development Executive - West Territory
$140K - $180K *
Advance healthcare by driving product adoption and education in colorectal cancer screening across a key geographic territory. Collaborate with healthcare providers to enhance market penetration and e...
Reposted 2 weeks ago
Specialty Development Executive - North Central Territory
$130K - $140K *
Help us drive the adoption of innovative colorectal cancer screening solutions by effectively engaging healthcare providers through education, consultation, and strategic support in your assigned terr...
Reposted 2 weeks ago
$180K - $220K *
Shape the future of compassionate care by leading a multidisciplinary team to enhance the quality of life for patients in their final stages, ensuring comfort, dignity, and emotional support through p...
1 week ago
$66K - $99K *
Champion patient care by utilizing your nursing expertise to lead clinical teams, coordinate care, and mentor staff. Engage in effective communication and critical thinking to enhance patient outcomes...
1 week ago
Specialty Development Executive - Southeast Territory
$130K - $140K *
Empower healthcare providers by promoting innovative colorectal cancer screening solutions, delivering exceptional support and education while strategically expanding product adoption across a designa...
Reposted 2 weeks ago
Specialty Development Executive - Northeast Territory
$130K - $140K *
Accelerate the growth of colorectal cancer screening solutions by engaging healthcare providers and driving product adoption. Collaborate with partners while strategically planning to maximize market...
Reposted 2 weeks ago
Clinical Applications Specialist, Contrast Media Delivery Solutions
$100K - $150K *
Join a team that's dedicated to enhancing clinical support through technical expertise and customer training. Drive product demonstrations and ensure customer satisfaction while collaborating with sal...
2 weeks ago
National Director, Integrated Specialty Practices
$160K - $200K *
Drive strategic growth and business development for National Accounts in Urology and Oncology, optimizing resources and leading negotiations to enhance healthcare outcomes through innovative diagnosti...
3 weeks ago
$145K - $165K *
Drive impactful clinical research strategies by collaborating with cross-functional teams, analyzing data, and disseminating findings through publications and presentations. Elevate your career while...
Today
Medical Specialist I Pulmonology Los Angeles East
$140K - $190K *
Join a team that's dedicated to driving revenue growth in the Pulmonary sector by engaging healthcare professionals and implementing strategic initiatives to enhance product utilization and foster str...
3 weeks ago
$120K - $250K *
Transform clinical trials by ensuring patient safety and scientific integrity. Collaborate with stakeholders to uphold regulatory standards and optimize study protocols, while providing expert medical...
2 weeks ago
Director, Integrated Specialty Practices
$150K - $180K *
Help us drive business development in oncology by leading strategic partnerships and optimizing resources to enhance clinical outcomes and market potential for our innovative diagnostic and therapeuti...
4 weeks ago
Medical Director - Critical Care
$300K - $309K *
Transform patient care by leading medical strategy and clinical innovation. As a vital member of the team, you'll guide product development and trial execution while engaging with key stakeholders to...
Reposted 3 weeks ago
Specialty Development Executive - Atlantic Territory
$130K - $140K *
Elevate your career by joining a dynamic sales team driving colorectal cancer screening solutions. Engage healthcare professionals, provide education, and strategize business growth across a vibrant t...
Reposted 2 weeks ago
Principal, Data Governance Platforms
$149K - $224K *
Shape the future of data governance by leading the design and implementation of enterprise platforms that ensure data integrity, quality, and compliance across the organization, while collaborating wi...
2 weeks ago
$198K - $297K *
Champion utilization management by conducting patient reviews, collaborating with medical staff, and leading initiatives to enhance compliance and efficiency. Drive results through effective communica...
Yesterday
$210K - $250K *
Deliver comprehensive case reviews and clinical guidance, ensuring regulatory compliance and optimal patient outcomes. Collaborate with healthcare teams across multiple states to enhance service quali...
3 weeks ago
Director, Sales – Global Strategic Accounts
$150K - $180K *
Empower a high-performing sales team to drive strategic growth and customer engagement in the biopharma sector. Lead complex sales initiatives, build executive relationships, and translate business st...
Yesterday
Theranostics Specialist - Southeast
$110K - $130K *
Advance the adoption of cutting-edge prostate cancer imaging solutions while leading site activations, enhancing workflows, and ensuring optimal product utilization in the oncology sector, supporting...
Reposted 3 weeks ago
Diagnosis-Related Group (DRG) Auditor III
$73K - $98K *
Join a team that's dedicated to excellence in DRG auditing. Leverage your expertise in MS-DRG and APR-DRG coding to ensure accuracy and compliance while working remotely. Enjoy a collaborative environ...
Today
Clinical Director, Clinical Development
$221K - $335K *
Elevate clinical research by leading innovative studies, ensuring data integrity and patient safety. Collaborate cross-functionally to drive strategic initiatives and enhance clinical development whil...
Today
Data and AI Governance Specialist
$108K - $149K *
Advance the organization by establishing robust data and AI governance practices. Collaborate across teams to ensure compliance, integrity, and responsible usage of data and AI assets, supporting both...
Reposted 6 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.