Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Director/Sr. Director, Patient Support Programs
$150K - $180K *
Join a team that's dedicated to enhancing patient access through strategic design and management of support programs. Oversee vendor relationships and ensure compliance while driving initiatives that...
3 weeks ago
$95K - $115K *
Champion compliance and security excellence by driving NIST 800-53 and FedRAMP initiatives. Partner with clients to ensure federal authorization, author vital documents, and manage multiple A&A projec...
Reposted 2 weeks ago
$100K - $120K *
Unlock growth potential by managing strategic accounts and cultivating executive relationships. Drive revenue through tailored strategies and consultative selling, while aligning cross-functional team...
Reposted 2 weeks ago
$116K - $167K *
Elevate your career by leading planned giving strategies and donor engagement. Collaborate across teams to enhance legacy giving, cultivate relationships, and drive philanthropic support while managin...
2 weeks ago
Senior Director, Regulatory CMC
$220K - $275K *
Elevate your career by leading global CMC regulatory strategies for biologics. Collaborate with cross-functional teams, ensure compliance, and drive successful product development while mentoring a hi...
Reposted 3 weeks ago
$100K - $120K *
Drive the development and integration of advanced nuclear energy systems by applying systems engineering methods to translate objectives into clear, verifiable requirements and solutions, while collab...
1 week ago
Solution Sales Executive - Governance Risk & Compliance
$143K - $230K *
Drive customer acquisition by leveraging your expertise in Governance, Risk, and Compliance solutions. Collaborate with sales teams to identify opportunities, present compelling demonstrations, and cl...
2 weeks ago
Solution Architect, Identity Security
$200K - $250K *
Shape the future of enterprise solutions by bridging technical expertise and strategic vision. Collaborate with cross-functional teams to design impactful architectures that drive customer success and...
1 week ago
Senior Manager, PVRM Safety Scientist
$157K - $196K *
Drive safety evaluation and risk management for assigned programs, collaborating with cross-functional teams to ensure compliance and effective governance in pharmacovigilance activities, while suppor...
Today
Assistant Superintendent- Special Projects
$80K - $95K *
Unlock your potential as a key player in our Special Projects Division, driving construction excellence through effective planning, communication, and safety compliance while managing project schedule...
2 weeks ago
Senior Manager, Global Site Start-Up Lead
$134K - $219K *
Unlock potential by leading global site start-up strategies for complex clinical trials. Drive operational excellence, ensure compliance, and collaborate with cross-functional teams to accelerate stud...
Reposted 2 weeks ago
Deputy Director, Partnerships & Technical Integration
$196K - $210K *
Partner with us to shape the future of semiconductor workforce development by aligning industry needs with educational strategies, fostering partnerships, and leading initiatives that ensure technical...
Reposted yesterday
$74K - $92K *
Empower our channel partner division by managing operational activities, coordinating RFPs, and driving cross-functional collaboration to enhance sales and partner engagement. Your insights will shape...
2 days ago
Core Enterprise Account Executive Midwest
$222K - $278K *
Manage strategic enterprise customer relationships, drive complex sales cycles, and inspire transformation through innovative solutions, impacting industries that power our world and enhancing efficie...
Reposted 2 weeks ago
Senior Director, Market Access Pricing & Contracting
$175K - $210K *
Drive the development and execution of U.S. pricing and contracting strategies, optimizing patient access and revenue performance. Collaborate across functions to ensure successful commercialization a...
3 weeks ago
Contracts Administration, Senior Advisor
$112K - $179K *
Transform the contract management landscape by expertly overseeing diverse government contracts, optimizing processes, and guiding teams to success from proposal to closeout while fostering robust sta...
Reposted 6 days ago
Contracts Administration, Senior Advisor
$112K - $179K *
Take ownership of a diverse portfolio of GSA/GWAC contracts, ensuring compliance and operational excellence through strategic management, collaboration with stakeholders, and training initiatives for...
1 month ago
Lead, Operations Strategy - Specialty Services Implementation
$90K - $100K *
Join a dynamic team to drive the implementation of innovative service lines, enhancing clinician and patient experiences. Collaborate cross-functionally to optimize operations and lead initiatives tha...
2 weeks ago
Deal Advisory Director (Healthcare)
$192K - $334K *
Tackle complex healthcare M&A engagements, leading due diligence efforts, and collaborating with clients and teams to drive value. Manage multiple projects while utilizing your expertise to influence...
Reposted 3 weeks ago
$125K - $150K *
Lead the charge in transforming public sector consulting by guiding organizations through digital transformation and ERP implementations, while managing high-impact teams and fostering client relation...
3 weeks ago
Pathology Coder III - Remote - 140825
$78K - $103K *
Champion accurate coding by interpreting diagnoses and resolving claim errors in this remote role. Leverage your expertise to ensure compliance with CPT, ICD-10, and HCPCS standards while collaboratin...
Reposted 2 days ago
Clinical Sales Representative - Atlanta
$100K - $120K *
Provide strategic leadership in territory management, driving revenue growth and innovation within complex healthcare environments. Cultivate executive relationships and promote clinical adoption to e...
Reposted 3 weeks ago
Account Specialist (Roseville, CA)
$160K - $192K *
Accelerate progress at driving commercial performance by engaging healthcare providers, building relationships, and supporting product launches to ensure patient access to innovative therapies across...
1 week ago
Director, Insights and Analytics
$150K - $180K *
Optimize your career by leading insights-driven strategies that shape brand decisions. Collaborate across functions to deliver actionable market research and analysis, driving impactful outcomes in a...
3 weeks ago
Senior Product Manager, Enterprise Solutions
$174K - $218K *
Reimagine healthcare by shaping partnerships that drive innovative virtual-first care solutions. As a Senior Product Manager, you will bridge product and commercial teams, enhancing member engagement...
Reposted 4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.