Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Gastroenterologist Jobs in South Dakota

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$141K - $211K *

Transform clinical and revenue-cycle operations by leading cross-functional teams to optimize technology solutions, ensuring efficient charge capture and financial reporting while enhancing patient sa...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$98K - $163K *

Drive your career forward by transforming financial management processes, enhancing operational efficiency, and collaborating with senior stakeholders to implement innovative solutions in a dynamic co...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$82K *

Provide skilled physical therapy services, evaluating patients and developing tailored treatment plans to restore function and mobility while ensuring compliance with regulations and collaborating wit...

Today

  •   Less than 5 years exp.  •   Staffing

$330K - $390K *

Join a team that's driving enterprise-level strategic statistical leadership across Biostatistics. You'll oversee programs, mentor statisitians, and ensure collaboration for successful drug developmen...

United StatesRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead complex compensation initiatives, ensuring equitable pay programs while managing projects. Serve as a subject matter expert in various compensation areas and collaborate with teams to enhance org...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $110K *

Shape the future of technical content by building a robust function from the ground up, focusing on client engagement and leveraging emerging technologies to enhance understanding and communication...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$86K - $138K *

Champion financial analysis and reporting by conducting in-depth research, preparing forecasts, and collaborating across departments to enhance decision-making and drive business success...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$170K - $220K *

Drive product strategy and development to enhance clinician experience, optimizing patient care through innovative solutions and stakeholder collaboration across a nationwide healthcare network...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$116K - $155K *

Shape the future of HR technology by leading strategy, governance, and optimization of HRIS. Drive operational excellence, enhance user experience, and ensure compliance while managing a high-performi...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$90K - $178K *

Transform the patient engagement landscape in clinical trials by developing and delivering strategic support initiatives. Partner with diverse stakeholders to enhance participation and optimize patien...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $110K *

Optimize customer satisfaction by servicing and maintaining medical imaging equipment. Leverage your expertise to install, troubleshoot, and train operators, while managing financial performance and f...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Elevate your career by supporting clinical studies through scientific expertise, operational delivery, and compliance. Collaborate with cross-functional teams and stakeholders to ensure successful tri...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $130K *

Elevate financial management and strategic planning efforts by providing expert analysis, guidance, and support for budget formulation and execution within a dynamic team focused on mission delivery f...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$177K - $221K *

Champion regulatory excellence by leading cross-functional teams, ensuring compliance, and driving successful oncology drug development through strategic planning and expert guidance...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $158K *

Champion high-availability database platforms, driving automation and cloud modernization. Collaborate with engineering teams to enhance reliability and performance across hybrid environments, ensurin...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Analyze and evaluate network anomalies in a 24/7 SOC environment. Collaborate with analysts on cyber threats, develop incident reports, and enhance SOC processes. Build test labs for research and prov...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $216K *

Transform program administration for a large federal services initiative, overseeing workforce planning, financial operations, and compliance. Collaborate with diverse teams to enhance operational eff...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$145K - $160K *

Lead the charge in transforming member support by defining strategy, enhancing team performance, and integrating AI solutions. Drive operational excellence while fostering a culture of empathy and acc...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$69K - $101K *

Lead the charge in holistic clinical care management, enhancing health outcomes through comprehensive assessments, care planning, and coordination for diverse member populations with complex needs...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$70K - $99K *

Empower our digital marketing efforts by managing website updates, social media, and email campaigns. Analyze performance data to drive actionable insights, enhance engagement, and support organizatio...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $90K *

Elevate your career by building and maintaining a network of specialist consultants and physicians. Drive business growth and enhance clinical trial delivery through strong relationships and strategic...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$128K - $178K *

Lead the evolution of our CMS and AI web strategy, driving product vision and execution for public sector clients. Collaborate with cross-functional teams to deliver innovative, customer-focused solut...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$168K - $285K *

Shape the future of financial strategy by leading R&D finance, partnering with executives to drive investment decisions, optimize spending, and enhance forecasting accuracy in a dynamic, AI-driven env...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$175K - $220K *

Shape the future of healthcare real estate by leading a dynamic transaction management team. Oversee negotiations, staff development, and strategic planning to drive client success and enhance operati...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$240K - $270K *

Architect the financial backbone of a rapidly scaling AI-focused organization. Collaborate with leadership to design systems, drive compliance, and enable international expansion while leveraging AI f...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.