Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Dir, EHR Revenue Cycle Applications
$141K - $211K *
Transform clinical and revenue-cycle operations by leading cross-functional teams to optimize technology solutions, ensuring efficient charge capture and financial reporting while enhancing patient sa...
6 days ago
Senior Financial Transformation Consultant
$98K - $163K *
Drive your career forward by transforming financial management processes, enhancing operational efficiency, and collaborating with senior stakeholders to implement innovative solutions in a dynamic co...
1 week ago
Physical Therapist | Physical Therapist | Shift 5x8 Days
$82K *
Provide skilled physical therapy services, evaluating patients and developing tailored treatment plans to restore function and mobility while ensuring compliance with regulations and collaborating wit...
Today
$330K - $390K *
Join a team that's driving enterprise-level strategic statistical leadership across Biostatistics. You'll oversee programs, mentor statisitians, and ensure collaboration for successful drug developmen...
Reposted 3 weeks ago
Senior Compensation Consultant
$110K - $130K *
Lead complex compensation initiatives, ensuring equitable pay programs while managing projects. Serve as a subject matter expert in various compensation areas and collaborate with teams to enhance org...
Reposted 6 days ago
$90K - $110K *
Shape the future of technical content by building a robust function from the ground up, focusing on client engagement and leveraging emerging technologies to enhance understanding and communication...
6 days ago
$86K - $138K *
Champion financial analysis and reporting by conducting in-depth research, preparing forecasts, and collaborating across departments to enhance decision-making and drive business success...
1 week ago
Senior Product Manager, Provider Experience
$170K - $220K *
Drive product strategy and development to enhance clinician experience, optimizing patient care through innovative solutions and stakeholder collaboration across a nationwide healthcare network...
2 weeks ago
$116K - $155K *
Shape the future of HR technology by leading strategy, governance, and optimization of HRIS. Drive operational excellence, enhance user experience, and ensure compliance while managing a high-performi...
4 days ago
Patient and Site Engagement Lead (US/UK)
$90K - $178K *
Transform the patient engagement landscape in clinical trials by developing and delivering strategic support initiatives. Partner with diverse stakeholders to enhance participation and optimize patien...
Reposted 1 week ago
Medical Imaging Field Engineer - CT/MI - Hershey, PA
$80K - $110K *
Optimize customer satisfaction by servicing and maintaining medical imaging equipment. Leverage your expertise to install, troubleshoot, and train operators, while managing financial performance and f...
1 week ago
Clinical Scientist - Oncology - Home-based anywhere in the US - FSP
$110K - $130K *
Elevate your career by supporting clinical studies through scientific expertise, operational delivery, and compliance. Collaborate with cross-functional teams and stakeholders to ensure successful tri...
4 weeks ago
Senior Financial and Budget Analyst (Remote)
$120K - $130K *
Elevate financial management and strategic planning efforts by providing expert analysis, guidance, and support for budget formulation and execution within a dynamic team focused on mission delivery f...
2 weeks ago
Associate Director, Regulatory Science
$177K - $221K *
Champion regulatory excellence by leading cross-functional teams, ensuring compliance, and driving successful oncology drug development through strategic planning and expert guidance...
1 week ago
$95K - $158K *
Champion high-availability database platforms, driving automation and cloud modernization. Collaborate with engineering teams to enhance reliability and performance across hybrid environments, ensurin...
2 weeks ago
$110K - $130K *
Analyze and evaluate network anomalies in a 24/7 SOC environment. Collaborate with analysts on cyber threats, develop incident reports, and enhance SOC processes. Build test labs for research and prov...
2 weeks ago
Program Administration Director
$130K - $216K *
Transform program administration for a large federal services initiative, overseeing workforce planning, financial operations, and compliance. Collaborate with diverse teams to enhance operational eff...
2 weeks ago
$145K - $160K *
Lead the charge in transforming member support by defining strategy, enhancing team performance, and integrating AI solutions. Drive operational excellence while fostering a culture of empathy and acc...
3 days ago
$69K - $101K *
Lead the charge in holistic clinical care management, enhancing health outcomes through comprehensive assessments, care planning, and coordination for diverse member populations with complex needs...
2 weeks ago
Digital Marketing Channel Specialist
$70K - $99K *
Empower our digital marketing efforts by managing website updates, social media, and email campaigns. Analyze performance data to drive actionable insights, enhance engagement, and support organizatio...
2 weeks ago
$80K - $90K *
Elevate your career by building and maintaining a network of specialist consultants and physicians. Drive business growth and enhance clinical trial delivery through strong relationships and strategic...
Yesterday
Manager, Product Management - Content Management Systems
$128K - $178K *
Lead the evolution of our CMS and AI web strategy, driving product vision and execution for public sector clients. Collaborate with cross-functional teams to deliver innovative, customer-focused solut...
6 days ago
$168K - $285K *
Shape the future of financial strategy by leading R&D finance, partnering with executives to drive investment decisions, optimize spending, and enhance forecasting accuracy in a dynamic, AI-driven env...
2 weeks ago
Transaction Management Director - Healthcare
$175K - $220K *
Shape the future of healthcare real estate by leading a dynamic transaction management team. Oversee negotiations, staff development, and strategic planning to drive client success and enhance operati...
6 days ago
Chief Financial Officer, The AI Access Initiative
$240K - $270K *
Architect the financial backbone of a rapidly scaling AI-focused organization. Collaborate with leadership to design systems, drive compliance, and enable international expansion while leveraging AI f...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.