Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Sr. Architect, Professional Services (Alteryx Experience Preferred)
$121K - $132K *
Lead the charge in architecting and implementing scalable analytics solutions for enterprise customers, while collaborating with cross-functional teams to ensure successful platform adoption and opera...
4 weeks ago
$112K - $140K *
Transform your career by leading claims advocacy efforts, managing complex coverage issues, and providing expert guidance to brokers and clients. Collaborate with teams to ensure positive outcomes and...
3 weeks ago
$164K - $305K *
Lead the charge in developing strategic relationships with C-suite executives to drive growth, retention, and value realization across complex health systems, ensuring integrated solutions and measura...
1 week ago
Certified Registered Nurse Anesthetist | Rapid City Hospital
$160K - $190K *
Shape the future of anesthetic care by collaborating with a dedicated team to provide safe, patient-focused services. Your expertise will drive quality outcomes in a supportive environment that champi...
Reposted today
Executive Director, Total Rewards
$168K - $240K *
Lead total rewards strategy for a complex global healthcare tech firm. Drive compensation and benefits governance, align workforce investment with business goals, and ensure compliance while fostering...
Reposted 4 weeks ago
Associate Director, Regulatory Project Management
$136K - $220K *
Unlock project management excellence in Global Regulatory Affairs, driving timelines and compliance for drug submissions. Collaborate cross-functionally to ensure accurate documentation and effective...
Reposted 2 weeks ago
Senior Support Solutions Specialist
$85K - $95K *
Join as a critical team member to manage and enhance productivity platforms, ensuring stability, security, and user satisfaction. Collaborate across teams to drive operational maturity and navigate co...
1 month ago
Section 508 Specialist, Advisor
$86K - $138K *
Transform documentation practices by leading accessibility initiatives, ensuring compliance with federal standards, and mentoring a team of writers to enhance the quality and efficiency of deliverable...
Yesterday
Director, Consultant Relations
$130K - $170K *
Partner with us to enhance consultant relationships in healthcare. Drive business growth by cultivating partnerships, optimizing engagement strategies, and aligning internal teams to effectively posit...
1 month ago
$140K - $185K *
Unlock the power of enterprise data as you design and implement Master Data Management solutions that enhance healthcare operations, drive analytics, and enable AI-driven decision-making with trusted...
Reposted 3 weeks ago
$152K - $202K *
Drive patient access by leveraging your expertise in reimbursement and market access. Collaborate with healthcare providers to navigate complex payer landscapes, ensuring timely access to therapies wh...
3 weeks ago
SENIOR TECHNOLOGY CONTROLS AND COMPLIANCE ANALYST- REMOTE
$115K - $130K *
Join a team that's committed to enhancing regulatory compliance through strategic initiatives, robust IT control design, and effective collaboration across business units to ensure adherence to indust...
Reposted yesterday
Director of Knowledge Management - NAMER
$135K - $160K *
Grow your career with a dynamic team focused on enhancing knowledge management. Lead strategic initiatives, develop talent, and shape self-service experiences while collaborating across departments to...
Today
Senior Oncology Account Manager, Phoenix West
$150K - $230K *
Engineer impactful relationships in oncology by promoting innovative therapies, driving patient access, and exceeding performance goals. Collaborate with stakeholders to enhance care delivery and leve...
1 week ago
Senior Clinical Trial Manager (CTM)
$168K - $188K *
Oversee and manage clinical trials from protocol development to final report, ensuring compliance with GCP and regulatory standards. Collaborate with cross-functional teams to enhance research efficie...
Reposted 4 weeks ago
Associate Director, Product Quality
$117K - $189K *
Join a team that's shaping the future of pharmaceutical quality by leading compliance initiatives and building a robust Quality Management System to support innovative therapies in a dynamic, collabor...
2 weeks ago
Senior Electrical Application Engineer
$125K - $160K *
Elevate your career by owning electrical application engineering for prefabricated platforms. Collaborate across disciplines to deliver scalable solutions, ensuring design integrity and execution read...
3 weeks ago
$200K - $215K *
Advance the cloud platform capabilities, ensuring secure, reliable, and scalable product delivery while enhancing developer experience and shaping reliability practices in a mission-driven healthcare...
4 weeks ago
Enterprise Software Account Manager
$100K - $110K *
Empower corporate veterinary groups by driving software adoption and growth. Collaborate with cross-functional teams to develop strategic partnerships, influence decisions, and enhance customer satisf...
2 days ago
Director, Business Development - RCM Sales
$125K - $150K *
Unlock potential by leading sales strategies that drive revenue growth, collaborating with experts to execute impactful cycles, and consistently achieving quotas in a dynamic market focused on health...
1 month ago
Medicaid Certification Consultant
$70K - $120K *
Lead transformative Medicaid initiatives by guiding project oversight, ensuring timely execution, and enhancing stakeholder engagement. Collaborate with teams to streamline operations and achieve stra...
1 week ago
$61K - $165K *
Join a team that's dedicated to enhancing CAD systems and engineering data management. Drive best practices, support users, and ensure data integrity while collaborating across departments to optimize...
1 week ago
Account Executive (Oncology) Philly
$63K - $112K *
Join a team that's dedicated to enhancing client relationships and driving sales growth through effective product presentations and customer feedback. Collaborate with marketing and sales staff to ens...
1 week ago
$100K - $130K *
Grow your career with a dynamic role that involves conducting in-depth research across various topics, delivering actionable insights, and collaborating with a high-performing team to tackle complex q...
3 weeks ago
Health and Human Services Senior Consultant
$80K - $135K *
Lead the charge in human services policy consulting to enhance operations and compliance for government agencies. Utilize expertise in federal regulations and stakeholder engagement to provide actiona...
4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.