Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$147K - $274K *
Empower innovation by leading applied AI research initiatives that shape product features. Collaborate with cross-functional teams to translate complex problems into impactful AI solutions, mentoring...
6 days ago
Senior Manager, Growth Marketing
$110K - $130K *
Accelerate progress at an innovative healthcare firm by leading account-based marketing initiatives. Collaborate closely with Sales to create impactful marketing plays that engage targeted health syst...
1 month ago
$63K - $96K *
Accelerate progress at the forefront of clinical technology, supporting multi-user systems and enhancing workflows. Collaborate with teams to optimize applications, ensuring effective use and continuo...
Yesterday
Enterprise Account Executive - Financial Services
$240K - $330K *
Join a team that’s pioneering growth in revenue intelligence by driving new business opportunities in financial services and healthcare. Leverage your extensive sales expertise to build relationships...
Reposted yesterday
Principal Technical Marketing Engineer | US | Remote
$183K - $220K *
Elevate technical storytelling by creating impactful demos and workshops that bridge the gap between product capabilities and customer understanding, empowering sales teams and enhancing buyer engagem...
6 days ago
Account Manager, Molecular Diagnostics, QIAstat (Midwest)
$100K - $120K *
Advance healthcare solutions by driving sales of innovative diagnostic instruments. Engage with key stakeholders to promote QIAstat-Dx systems, ensuring successful adoption and customer satisfaction t...
3 days ago
Product Manager, Clinical Programs & Case Management
$86K - $138K *
Unlock innovative healthcare solutions by leading product strategy and lifecycle management for clinical programs. Collaborate across teams to enhance member experiences and drive business value while...
1 week ago
$108K - $135K *
Join our team as a Telehealth Pharmacist, where you'll enhance member health through Medication Therapy Management and clinical outreach programs, ensuring high-quality care and compliance with indust...
4 days ago
$250K - $290K *
Champion growth by developing best-in-class business practices, leading a high-performing new business team, managing pipeline opportunities, and fostering strategic partnerships with leadership to dr...
Reposted 2 weeks ago
Cardiovascular Account Specialist - U.S. Sales, San Antonio, TX
$162K - $195K *
Take ownership of driving sales performance in your territory by launching a novel cardiac myosin inhibitor. Collaborate with internal teams and external stakeholders to build strategic relationships...
1 week ago
Regional Business Director, Southeast
$230K - $260K *
Join us to lead a regional sales team, driving strategic initiatives and fostering relationships to achieve business objectives while enhancing patient outcomes in the oncology sector...
1 week ago
Account Executive - Business Development Sales, Healthcare SaaS
$150K - $180K *
Advance healthcare solutions by building executive relationships and driving enterprise sales. Lead the sales lifecycle, develop strategic accounts, and leverage modern tools to optimize revenue growt...
Yesterday
$152K - $190K *
Drive the future of data analytics by leading a dynamic team to enhance enterprise data strategies, governance, and insights that align with business objectives and foster innovation across the organi...
Today
$83K - $108K *
Join a team that's dedicated to nurturing key accounts and driving customer success. You'll cultivate long-term relationships, collaborate across departments, and ensure optimal performance for our hi...
Reposted 6 days ago
$80K - $95K *
Support clients by providing expert technical assistance and fostering strong relationships. Analyze software usage to enhance client success and drive retention through proactive engagement and colla...
Reposted 6 days ago
$100K - $120K *
Engage in new business acquisition by identifying, qualifying, and closing sales opportunities. Build strong client relationships and deliver tailored presentations while achieving sales quotas in a d...
3 weeks ago
Associate Vice President, Clinical Services - Market Access Marketing
$180K - $220K *
Lead the charge in developing clinical content strategies and overseeing teams within the market access practice. Drive innovation, enhance client strategies, and ensure high standards in service deli...
Reposted 3 weeks ago
Territory Manager | Central Coast
$90K - $180K *
Take ownership of market expansion by driving adoption of innovative medical solutions. Leverage your sales expertise to build relationships with healthcare professionals and capture market share with...
Reposted 6 days ago
IT and Enterprise GTM Strategy, Director
$190K *
Unlock potential by leading strategic initiatives that engage IT and enterprise buyers. Drive value creation, develop go-to-market strategies, and build cross-functional teams to enhance market presen...
3 weeks ago
Account Specialist (Peachtree City, GA)
$160K - $192K *
Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative...
5 days ago
Director, Market Access Payer Accounts - Northeast
$197K - $246K *
Lead strategic initiatives in market access by managing key payer accounts, ensuring optimal coverage and reimbursement for products. Collaborate with cross-functional teams to enhance patient access...
1 week ago
Sr Regional Manager - Contact Center Back Office Support - Patient Access
$72K - $94K *
Transform patient access operations by leading centralized support functions, optimizing workflows, and enhancing service quality across multiple regions. Drive continuous improvement and develop lead...
1 week ago
$102K - $154K *
Advance customer success by managing complex escalations, driving cross-functional improvements, and enhancing workflows. Lead high-severity issue resolution while fostering a structured, customer-cen...
4 weeks ago
Site Reliability Engineering Lead
$118K - $219K *
Transform the future of cloud infrastructure by leading a dynamic SRE team, driving automation, and enhancing operational excellence across scalable platforms while fostering collaboration and continu...
4 weeks ago
Senior Oncology Account Manager, Milwaukee
$150K - $230K *
Join a team that's dedicated to advancing oncology care by promoting innovative products and building strong relationships with healthcare professionals. Leverage your expertise to drive brand value a...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.