Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Implementation Manager - Data Solutions
$91K - $145K *
Shape the future of data solutions by leading complex pharmacy claims and physician-level data integrations. Collaborate with cross-functional teams to deliver high-quality, scalable solutions that me...
3 weeks ago
Healthcare Tech Manager - Epic Patient Access
$130K - $150K *
Drive impactful solutions as a Healthcare Technology Manager, optimizing Epic Patient Access systems. Collaborate with clients and teams to enhance workflows and deliver sustainable results in a suppo...
2 weeks ago
Senior Strategic Alliance Manager
$210K - $253K *
Lead strategic partnerships to drive growth and success in a dynamic healthcare ecosystem. Collaborate with internal teams and external stakeholders to enhance relationships, execute activation plans...
2 days ago
Product Manager - Find & Schedule Care
$86K - $138K *
Champion the seamless member experience in healthcare access by defining product strategy and overseeing execution. Drive innovation in finding and scheduling care, ensuring accuracy and satisfaction...
Reposted 5 days ago
$75K - $90K *
Champion patient care by utilizing telehealth technologies to deliver high-quality nursing services. Collaborate with interdisciplinary teams to improve outcomes and ensure compliance with healthcare...
Reposted 2 weeks ago
eTailer Senior Account Manager, iHerb
$130K - $155K *
Accelerate progress at a leading eCommerce firm by driving global business strategy, overseeing P&L, and enhancing marketplace operations. Leverage your expertise in digital marketing and account mana...
Today
Director, Executive Compensation
$156K - $227K *
Elevate executive compensation strategies by designing and leading Total Rewards programs that align with organizational goals, while collaborating with key stakeholders to ensure compliance and effec...
3 days ago
Senior Oncology Account Manager, Boston North
$150K - $230K *
Lead the charge in advancing oncology care by building strong relationships with key stakeholders, driving product adoption, and ensuring patient access to innovative therapies in a dynamic biopharma...
1 week ago
Senior Software Engineer- Backend GoLang (Remote)
$89K - $170K *
Pioneer innovative software solutions by developing and maintaining high-quality applications. Collaborate within a cross-functional team to enhance system performance and reliability, ensuring except...
Reposted 3 days ago
Senior Director, Global Infrastructure Technology & Operations
$222K - $288K *
Advance your career by leading global infrastructure strategy and operations. Drive modernization across cloud, networking, and security while ensuring compliance and scalability for 24/7 clinical and...
Reposted 2 days ago
$80K - $95K *
Optimize coding education and compliance for healthcare providers. Lead a team to enhance clinical documentation, develop training plans, and ensure adherence to regulations, driving improvements in b...
2 weeks ago
$139K - $235K *
Lead the charge in transforming investor relations processes, enhancing communication of strategy and performance to the market. Collaborate with executives to manage investor relationships and delive...
3 days ago
Regional Vice President of Environmental Services
$220K - $250K *
Champion a high-performing team of leaders to drive operational excellence, enhance client relationships, and achieve strategic goals in a dynamic environment while fostering a culture of transparency...
Reposted 3 days ago
$120K - $150K *
Drive the success of a dynamic sales team by managing daily operations, coaching, and ensuring pipeline health. Collaborate with leadership to translate strategy into actionable priorities while foste...
2 weeks ago
Senior Oncology Account Manager, Minneapolis
$150K - $230K *
Champion innovative oncology solutions by building strong relationships with key stakeholders. Drive product success through strategic engagement and effective territory management, ensuring timely ac...
1 week ago
$125K - $150K *
Unlock potential by joining a high-impact team focused on managing global financial crime risks. Collaborate across functions to develop risk-based policies and controls that ensure compliance and sup...
2 weeks ago
Field Service Engineer - Image Guided Therapy (Field: Charlotte, NC)
$72K - $112K *
Serve as a vital link in healthcare by providing expert technical support for imaging equipment. You'll ensure optimal performance through installation, troubleshooting, and maintenance, while fosteri...
2 days ago
Director, Centralized Case Management
$110K - $130K *
Elevate your career by providing strategic leadership for a national remote case management team, ensuring service excellence, operational consistency, and client satisfaction while collaborating with...
3 weeks ago
$270K - $290K *
Join a team that's shaping innovative brand strategies for rare epilepsy programs. Lead marketing initiatives, drive launch readiness, and build a high-performing team to deliver impactful solutions f...
1 week ago
$172K - $215K *
Advance your career by leading software development initiatives, driving architecture design, and optimizing performance in a collaborative environment. Engage with cross-functional teams to deliver s...
Yesterday
$80K - $99K *
Help us elevate patient care as a Physical Therapist, treating diverse conditions while creating individualized plans. Experience mentorship and opportunities for professional growth in a collaborativ...
4 weeks ago
Dir/Sr Dir, Strategy & Delivery (Gen Med - Rare Disease - US and/or Canada)
$134K - $306K *
Elevate customer engagement by developing and executing strategic study plans, leading cross-functional teams, and ensuring successful project delivery in the rare disease therapeutic area...
2 weeks ago
$126K - $168K *
Transform the Connected Aircraft portfolio by leading product strategy and execution for Flight Management Systems. Collaborate cross-functionally to drive business growth, align customer needs, and d...
1 week ago
Transformation Consultant, Professional Services
$74K - $137K *
Lead the charge in transforming workflows with AI, driving adoption and measurable impact in legal, tax, and trade sectors. Collaborate with clients and teams to design, implement, and evaluate innova...
2 weeks ago
Executive Administrative Partner
$90K - $105K *
Partner with us to provide exceptional administrative support to a VP, managing complex calendars, travel logistics, and cross-functional relationships while ensuring smooth operations and effective c...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.