Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$142K - $195K *
Unlock potential by designing secure, enterprise-scale solutions that protect critical data and systems. Collaborate with stakeholders to assess threats, innovate security architecture, and enhance en...
Reposted 4 weeks ago
$227K - $385K *
Elevate member care by overseeing utilization management and evaluating treatment appropriateness. Collaborate with multidisciplinary teams, ensuring compliance with clinical standards and regulations...
Reposted 1 week ago
Account Executive, Small Group
$75K - $90K *
Lead the charge in driving sales growth by engaging independent physician practices. Utilize your expertise in full-cycle sales to build relationships, conduct virtual demos, and collaborate with team...
3 weeks ago
Thought Leader Liaison, US Oncology, West
$167K - $300K *
Lead the charge in oncology marketing by developing KOL engagement strategies and insights for individualized therapies. Collaborate cross-functionally to drive brand strategy and launch planning, ens...
3 days ago
$92K - $126K *
Drive innovative solutions by blending product analytics and low-code development, collaborating cross-functionally to enhance AI Agent capabilities and optimize Revenue Cycle operations within the he...
Reposted 1 week ago
$45K - $250K *
Transform your career by connecting healthcare professionals with meaningful roles. Join a supportive team focused on building relationships and driving results while enjoying unlimited earning potent...
1 week ago
Cyber Security Specialist Lead
$96K - $133K *
Support our cyber defense initiatives by leading incident response efforts, analyzing security events, and optimizing detection capabilities to enhance network security and protect sensitive data...
3 weeks ago
Hematology/Oncology Specialist - Hartford, CT
$170K - $210K *
Unlock potential by fostering relationships within the oncology community, executing strategic business plans, and ensuring patient access to therapies while collaborating across functions to drive sa...
Reposted 1 week ago
$240K - $300K *
Transform patient care by providing comprehensive medical evaluations, diagnoses, and treatments. Collaborate with healthcare teams to enhance health education and ensure quality care while adhering t...
6 days ago
$136K - $187K *
Join a team that's dedicated to empowering patients with generalized Myasthenia Gravis through education and support. As a key point of contact, you'll coordinate care, provide resources, and ensure c...
1 week ago
$85K - $100K *
Analyze performance metrics to empower ACOs in Value-Based Care programs. Collaborate with teams to provide actionable insights, track KPIs, and optimize risk scores, driving data-driven decisions for...
Today
Senior Analyst, Technical Implementation
$89K - $133K *
Empower success by leading healthcare technology implementations, optimizing workflows, and ensuring compliance. Collaborate across teams to guarantee smooth integrations and enhance system functional...
Reposted 1 week ago
$117K - $161K *
Empower our Quality Engineering operations by managing portfolio governance, financial planning, and resource allocation. Collaborate across teams to enhance transparency and execution, driving strate...
Reposted 2 weeks ago
$117K - $161K *
Shape the future of Quality Engineering by leading portfolio management, financial governance, and strategic execution. Collaborate across teams to enhance operational effectiveness and drive transfor...
Reposted 2 weeks ago
Physician | Neurosurgery Inpatient Only
$280K - $350K *
Lead the charge in providing exceptional medical care and patient education. Collaborate with a dedicated team to assess, diagnose, and treat patients, ensuring adherence to safety standards and quali...
1 week ago
Director, Global Regulatory Affairs - Cardiometabolic Disorders
$195K - $264K *
Drive global regulatory strategies for obesity and cardiometabolic disorders, ensuring alignment across teams and leading interactions with health authorities. Leverage scientific expertise to navigat...
Today
$100K - $120K *
Elevate your career by designing and optimizing EpicCare Ambulatory workflows. Collaborate with clinicians to enhance EHR functionality, troubleshoot issues, and ensure seamless operations across heal...
Yesterday
$148K - $256K *
Shape the future of data engineering by architecting scalable, cloud-native data platforms on Azure and Databricks. Influence the organization’s data practices to leverage AI-driven insights, driving...
Reposted 2 weeks ago
Medical Director, Post Acute Care
$207K - $346K *
Lead the charge in evidence-based medical case reviews to ensure high-quality patient care while collaborating with a network of over 500 physician colleagues in a fully remote environment...
Reposted 3 days ago
$115K - $135K *
Shape the future of clinical trials by leading site monitoring efforts, ensuring compliance, and fostering collaboration across teams. Drive quality and efficiency in trial execution while mentoring j...
3 weeks ago
$136K - $204K *
Champion impactful scientific dialogue with key healthcare leaders in Cardiology, promoting evidence-based practices and insights. Collaborate cross-functionally to enhance clinical decision-making an...
Reposted 2 weeks ago
$110K - $130K *
Transform patient care by engaging with Cardiology KOLs as a medical liaison, fostering scientific dialogue, and mentoring teams in advancing innovative healthcare strategies. Drive educational initia...
Reposted 2 weeks ago
Manager, Clinical Data Acquisition
$73K - $130K *
Drive the acquisition and usability of clinical data to enhance healthcare outcomes. Collaborate with diverse teams to analyze data gaps, implement integrations, and optimize processes, ensuring timel...
3 weeks ago
$175K - $210K *
Lead the charge in driving enterprise growth within healthcare by building relationships with national and regional health plans. Own new logo acquisition and expansion, leveraging a robust support sy...
1 week ago
Physician - Diagnostic Tele-Radiologist
$210K - $250K *
Grow your career by providing comprehensive diagnostic radiology services, including consultations and interpretations for a diverse patient population. Collaborate remotely to ensure timely and accur...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.