Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Vice President, Finance & Accounting
$160K - $190K *
Take ownership of financial strategy and operations, leading a dynamic finance team to enhance performance, ensure compliance, and drive growth in a collaborative, employee-owned environment...
2 days ago
Senior Director, Business Development
$194K - $266K *
Lead the charge in driving commercial growth by securing high-value partnerships and expanding market presence. Mentor a dynamic team while executing strategic initiatives that enhance client relation...
1 week ago
$164K - $205K *
Elevate scientific rigor in real-world evidence development. Collaborate with cross-functional teams to ensure agent conceptualization and evaluation meet scientific standards, driving impactful solut...
1 week ago
Advanced Practice Provider - Clinical Research Oncology
$85K - $100K *
Join a dynamic healthcare team as you manage complex patient populations, collaborating with physicians and nurses to deliver high-quality care. Utilize your expertise in a predominantly outpatient se...
2 weeks ago
$82K - $112K *
Shape compelling product narratives by leveraging market insights and AI tools. Collaborate cross-functionally to drive go-to-market strategies, ensuring impactful messaging and training materials tha...
1 week ago
$118K - $197K *
Lead and develop project quality engineers, ensuring quality deliverables meet standards and customer specifications across various high-voltage projects, while managing inspections, audits, and conti...
Reposted 1 week ago
Account Specialist, Gainesville-Daytona Beach, FL
$160K - $192K *
Accelerate commercial success by engaging healthcare providers and driving product adoption. Collaborate with cross-functional teams to optimize patient access and support innovative therapies in a dy...
1 week ago
Project Director, Dermatology and Rheumatology, CRO, US, remote USA
$125K - $150K *
Oversee a portfolio of clinical studies, ensuring compliance and quality. Lead Project Managers in executing complex trials, driving operational efficiency and client satisfaction while leveraging you...
2 weeks ago
1740 - Director, Strategic Sourcing Facilities- Healthcare
$125K - $185K *
Transform the future of healthcare sourcing by leading strategic initiatives, managing a dedicated team, and driving cost-saving projects across Facilities categories to ensure high-quality service de...
2 weeks ago
Workday Healthcare Financial Implementation Consultant
$140K - $210K *
Partner with us to drive innovative financial solutions in the healthcare sector. Leverage your Workday expertise for impactful implementations, collaborating closely with teams to transform operation...
Reposted 1 week ago
Clinical Trial Liaison (Oncology)
$100K - $120K *
Accelerate progress at clinical sites by enhancing patient recruitment strategies and supporting Oncology studies. Collaborate with teams to optimize enrollment processes and ensure effective communic...
2 days ago
Director, Strategic Growth & Operations
$150K - $200K *
Empower strategic growth and operations by integrating cross-functional teams, aligning priorities, and driving initiatives to enhance study delivery and operational excellence in a dynamic environmen...
Today
Staff Application Security Engineer
$182K - $215K *
Join our team to oversee application security, manage vulnerability pipelines, and collaborate with engineering teams to enhance security practices. Drive incident response and advocate for security a...
3 weeks ago
Vice President, Global Supply Chain
$272K - $340K *
Lead the charge in shaping a global supply chain strategy that ensures seamless delivery of clinical and commercial products. Build a high-performing team and foster partnerships to meet regulatory st...
2 weeks ago
$115K - $145K *
Engage in the development and delivery of innovative training programs that enhance the skills and performance of sales teams in the pharma/biotech sector, ensuring alignment with strategic goals and...
3 weeks ago
Executive Director, Clinical Supply Consulting & Intelligence
$250K - $350K *
Lead the development of a clinical supply consulting practice, combining expertise in forecasting, planning, and optimization to enhance decision-making for sponsors. Drive innovation and commercial g...
2 weeks ago
Software Engineer III - Full Stack, Angular, Java, AWS
$102K - $136K *
Empower your career by designing and delivering scalable software solutions in a dynamic environment. Collaborate with cross-functional teams to enhance healthcare supply chain products using modern t...
2 weeks ago
Lead Consultant CDH Implementation
$105K - $149K *
Transform complex Consumer-Directed Health implementations for major employers. Lead strategy, execution, and client engagement while serving as a subject-matter expert to ensure operational excellenc...
3 days ago
$85K - $100K *
Empower compliance excellence by leading audits, risk assessments, and investigations. Collaborate with teams to ensure adherence to healthcare regulations and promote ethical practices while adapting...
3 weeks ago
$120K - $150K *
Accelerate progress at the forefront of newborn health by leading strategic initiatives, managing multi-country programs, and driving impactful interventions to reduce neonatal mortality and stillbirt...
1 week ago
Senior Oncology Account Manager, Richmond
$150K - $230K *
Explore opportunities to drive oncology product success by building strong relationships with healthcare professionals, managing territory resources, and delivering impactful solutions that enhance pa...
1 week ago
$160K - $180K *
Elevate customer success by managing strategic federal programs, ensuring seamless implementation and adoption of innovative solutions. Collaborate with stakeholders to drive project execution and enh...
Today
National Compliance Consultant - Employee Health & Benefits
$89K - $166K *
Elevate your career as a Compliance Consultant, guiding clients through complex health and welfare benefits laws. Collaborate with experts, deliver training, and develop resources to ensure compliance...
1 week ago
$275K - $350K *
Lead the charge in transforming operations by integrating AI and technology to enhance member and clinician experiences, ensuring efficient care delivery and operational excellence across a distribute...
1 week ago
Staff Bioinformatics Scientist, Clinical Applications
$146K - $196K *
Transform genomic insights into clinical applications by designing automated solutions and integrating AI/ML approaches. Collaborate with cross-functional teams to enhance variant curation and ensure...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.