Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Marketing Manager, Media (Oncology | LVL)
$143K - $194K *
Join a team that drives the execution of integrated media plans, ensuring compliance and operational excellence. Collaborate with cross-functional teams while enhancing brand strategies in healthcare...
Reposted 2 days ago
APP - Nurse Practitioner or Physician Assistant | Neurology
$90K - $110K *
Join a team that's dedicated to providing advanced nursing care for patients with neurological conditions. Collaborate with specialists to assess, diagnose, and manage treatment plans while supporting...
3 weeks ago
$80K - $120K *
Shape your career as you take ownership of key accounts, driving sales and building relationships. Collaborate with top performers to modernize government services, while gaining invaluable experience...
2 days ago
Senior Director, Entertainment & Sports
$135K - $180K *
Lead strategic partnerships in healthcare, connecting brands with entertainment and sports. Collaborate with teams to develop, negotiate, and execute impactful initiatives that drive brand engagement...
Today
$150K - $215K *
Lead the charge in driving enterprise sales for strategic consulting accounts, coaching a team of Account Executives while managing complex sales cycles. Build executive relationships and execute grow...
2 weeks ago
$125K - $150K *
Empower legal firms by leading the development of innovative IT solutions, driving market strategies, and enhancing service offerings. Collaborate with cross-functional teams to establish credibility...
1 week ago
Senior Director - Business Finance
$206K - $268K *
Empower operational finance by leading cost-of-revenue functions, serving as a strategic partner to executives and enhancing organizational performance and scalability through effective leadership and...
Reposted 6 days ago
Clinical Applications Pharmacist
$95K - $115K *
Join our team to enhance clinical systems for medication management, focusing on optimizing workflows and supporting pharmacy operations. Collaborate with stakeholders to ensure accuracy and efficienc...
4 days ago
$201K - $251K *
Transform workforce intelligence by leading People Analytics, establishing data governance, and driving strategic decision-making in a high-growth environment. Collaborate across functions to enhance...
3 weeks ago
Senior Oncology Account Manager, San Jose
$150K - $230K *
Engage with key stakeholders to promote oncology products, build relationships, and drive brand value. Utilize market insights to develop strategic plans, ensuring patient access and exceeding perform...
1 week ago
$150K - $180K *
Drive client engagement and revenue growth by becoming a trusted advisor in Revenue Cycle Management. Leverage expertise to retain and expand business while ensuring client satisfaction across a diver...
2 weeks ago
Regulatory Policy and Intelligence Associate Director
$155K - $210K *
Shape the future of regulatory policy by leading initiatives that influence key decisions and drive alignment across teams. Collaborate with stakeholders to advocate for impactful policies that suppor...
Today
Senior Medical Science Liaison - Obesity & Related Conditions - IA/NE/SD
$172K - $233K *
Engage with healthcare leaders to advance scientific knowledge and improve patient outcomes in obesity care. Collaborate with internal and external stakeholders, support research initiatives, and ment...
2 days ago
Principal Consultant - Senior SAP Sales Executive
$150K - $180K *
Transform the SAP sales landscape by leveraging your extensive network and expertise to drive new business acquisition in the manufacturing sector. Own the full sales cycle, from lead generation to cl...
Yesterday
Application Analyst, PB Claims and Remittance
$80K - $95K *
Manage and optimize Epic Professional Billing workflows, focusing on Claims and Remittance. Serve as a key resource for end-users, troubleshooting issues and enhancing billing processes to ensure accu...
3 weeks ago
Triage Clinical Guide (Registered Nurse) - Care OnDemand
$85K - $110K *
Unlock better healthcare experiences by providing telephonic triage and support. As a key advocate for members, you'll connect them with essential resources, ensuring timely and appropriate care while...
Yesterday
Senior Manager, Global Scientific Communications & Engagement Strategy Global Publication Lead
$141K - $191K *
Lead the charge in developing high-impact scientific communications and engagement strategies, collaborating across teams to ensure compliance and compelling communication of clinical evidence to enha...
1 month ago
$120K - $160K *
Drive WellTheory's growth in benefits consulting by cultivating strong partnerships, educating consultants, and supporting client strategies. This hands-on, individual contributor role requires strate...
Reposted 4 weeks ago
Account Executive Director, Crypto + Stablecoin
$150K - $180K *
Drive strategic growth in the crypto sector, managing both greenfield and upsell opportunities. Lead enterprise sales cycles, consult with clients, and collaborate across teams to maximize account pot...
1 month ago
Manager, Endpoint Security Engineering
$102K - $190K *
Pioneer the future of endpoint security by leading a dynamic engineering team, ensuring operational excellence, and driving innovative capabilities to protect enterprise assets while aligning with bus...
3 days ago
Principal Scientist, CMC Analytical
$150K - $190K *
Unlock potential by leading analytical strategies for drug development, ensuring robust quality control throughout product lifecycle. Collaborate with partners to deliver exceptional insights that dri...
Reposted 3 weeks ago
Director of Operations, ES - Tampa, FL
$143K - $196K *
Elevate healthcare delivery by leading strategic partnerships and optimizing operations within Oncology service lines. Drive performance through exceptional customer engagement and collaboration acros...
2 weeks ago
$237K - $296K *
Join a team that's driving innovation in oncology by leading clinical development and medical affairs. Collaborate across functions to advance pivotal programs and ensure operational excellence in a f...
2 weeks ago
Director / Senior Director / Executive Director, Regulatory Affairs
$210K - $275K *
Transform regulatory affairs in oncology by leading strategic submission initiatives and cross-functional collaborations, ensuring compliance and quality for impactful development programs. Drive regu...
Reposted today
$95K - $115K *
Empower client success by leading technical implementations, ensuring data accuracy, and resolving complex challenges. Collaborate with cross-functional teams to enhance workflows and drive continuous...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.