Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Remote Medical Review Officer / Paramedic
$80K - $95K *
Transform healthcare outcomes by leveraging clinical expertise to review medical records, ensuring compliance with government standards while fostering collaboration and maintaining confidentiality in...
1 week ago
Senior Principal - Business Consulting
$210K - $256K *
Unlock potential by leading strategic payment modernization efforts, managing client relationships, and delivering complex digital solutions while collaborating across teams to enhance operational eff...
Reposted today
Account Executive Restaurants - US Countrywide
$100K - $120K *
Join a dynamic team to drive sales solutions and foster strong customer relationships within the restaurant sector, enhancing product offerings and customer satisfaction through strategic engagement a...
Reposted 2 weeks ago
$110K *
Champion the clinical operations team, ensuring project success through resource management, process efficiencies, and compliance. Drive training, metrics development, and mentorship to enhance team c...
Reposted 3 days ago
$90K - $110K *
Analyze clinical documentation and risk adjustment for healthcare providers, ensuring accurate representation of patient acuity. Collaborate with physicians to identify documentation opportunities and...
4 weeks ago
Public & Adolescent Health Managing Consultant
$113K - $188K *
Champion adolescent health initiatives by providing strategic guidance and support to federal agencies, enhancing youth engagement, and implementing evidence-based programs to improve outcomes for ado...
Yesterday
$85K - $141K *
Analyze loan files to ensure compliance with SBA requirements, identifying risks and deficiencies. Collaborate with lenders to clarify documentation and prepare detailed reports, maintaining high stan...
Yesterday
$184K - $230K *
Shape the future of product security by leading architecture reviews and risk mitigation strategies. Collaborate with engineering and compliance teams to embed security throughout the development life...
1 week ago
Clinical Oversight Manager (COM) - USA
$110K - $130K *
Accelerate progress at the forefront of clinical research by ensuring effective oversight and management of clinical studies. Collaborate with teams to uphold quality standards and drive successful st...
2 days ago
$78K - $131K *
Inspire growth by partnering with leaders to design impactful learning experiences that enhance performance across teams. Drive initiatives that empower employees to achieve their goals and improve pr...
1 week ago
Director - Performance Transformation
$206K - $343K *
Lead the charge in transforming healthcare operations by delivering innovative performance solutions. Drive profitable growth through strategic program management and client engagement, ensuring measu...
Yesterday
Principal Scientist, Formulation Development
$170K - $190K *
Lead formulation development from discovery to clinical stages, translating compounds into scalable processes. Collaborate with cross-functional teams to drive strategy, solve challenges, and ensure q...
2 weeks ago
Senior Medical Science Liaison, West (Multiple Territories)
$190K - $220K *
Champion scientific engagement by building relationships with key stakeholders, translating clinical data into actionable insights, and driving prelaunch strategies in a dynamic environment. Operate i...
1 week ago
$110K - $130K *
Drive go-to-market strategy for AI-powered healthcare solutions, collaborating cross-functionally to enhance product positioning, messaging, and performance. Own marketing execution and leverage insig...
1 week ago
$92K - $115K *
Transform client data integration processes by designing, building, and testing seamless connections between systems. Collaborate with teams to ensure optimal performance and security while delivering...
1 week ago
$124K - $155K *
Champion data-driven insights as you lead a multidisciplinary analytics team, driving client performance and strategic recommendations to enhance business growth and market competitiveness...
3 days ago
Product Director, Institutional Solutions
$126K - $168K *
Lead the charge in shaping and executing product strategy for B2B learning solutions, driving innovation and market impact while collaborating with cross-functional teams to deliver high-quality produ...
2 weeks ago
$170K - $230K *
Pioneer a high-performing sales team, driving revenue growth through strategic leadership and client engagement. Shape the future of our corporate sales efforts by optimizing processes and fostering c...
3 weeks ago
Senior Staff Forward Deployed Engineer
$152K - $205K *
Lead the charge in architecting AI-driven solutions for enterprise clients, transforming complex data governance challenges into actionable insights. Collaborate with stakeholders to shape product evo...
3 weeks ago
Manager, Revenue Cycle Operations
$100K - $130K *
Join a dynamic team to lead and enhance billing and coding operations, ensuring quality and compliance across multiple markets. Drive performance, coach leaders, and collaborate cross-functionally to...
3 weeks ago
$68K - $105K *
Help us lead enterprise-wide incident responses and internal investigations into misconduct, ensuring compliance and effective fraud detection while collaborating across departments to uphold organiza...
Reposted today
Senior Program Engineer, IT Services & Cloud Operations
$120K - $150K *
Drive complex federal platform initiatives, enhancing security, compliance, and infrastructure through innovative engineering solutions and cross-functional leadership...
Reposted 4 weeks ago
$80K - $95K *
Drive revenue cycle optimization by enhancing Epic Professional Billing workflows, collaborating with stakeholders, and resolving claims challenges to improve overall operational efficiency and ensure...
4 weeks ago
Director, Oncology Program Management
$178K - $238K *
Drive impactful oncology drug development by leading program management, optimizing team efficiency, and ensuring strategic alignment across global projects to enhance patient outcomes and organizatio...
Today
$127K - $171K *
Champion high-impact deployments by leveraging data intelligence and AI to drive governance solutions in regulated industries, serving as a trusted advisor to stakeholders and delivering measurable va...
Reposted 2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.