Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Gastroenterologist Jobs in South Dakota

Sort By: Relevance

$73K - $109K *

Champion customer satisfaction by mastering preventative maintenance and troubleshooting techniques. Collaborate with experienced engineers to enhance skills in equipment installation and service, ens...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$66K - $99K *

Play a key role in delivering exceptional service by performing preventative maintenance and troubleshooting on medical equipment. Collaborate with experienced engineers to enhance customer satisfacti...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$128K - $192K *

The Workday Financials Senior Principal Consultant, Record to Report is a dynamic professional responsible for leading the Financials workstream and ensuring operational efficiency in Workday engageme...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Champion privacy solutions by engaging with clients, delivering tailored demos, and driving sales success. Leverage your expertise to influence product development and navigate the intersection of AI...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$185K - $344K *

Join a team that's redefining market access through innovative data partnerships. Lead strategic collaborations, ensure data compliance, and drive insights that enhance decision-making and patient ser...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Drive impactful oncology solutions by building relationships with key stakeholders. Leverage your expertise to promote innovative products, exceed performance goals, and enhance patient access while n...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$235K - $329K *

Lead clinical pharmacology initiatives, overseeing drug development across infectious disease and oncology programs. Collaborate with cross-functional teams to drive strategic advancements and ensure...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Join us to drive strategic sales growth across key verticals in the South Central U.S. Lead complex enterprise sales cycles, engage with C-suite stakeholders, and develop a robust pipeline to achieve...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$180K - $200K *

Reimagine security engineering leadership by guiding strategic initiatives across cloud and infrastructure security, enhancing detection engineering, and fostering collaboration to protect a multi-clo...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$160K - $180K *

Champion growth and satisfaction by managing key Ecosystem client relationships. Drive sales of innovative data solutions in Life Sciences, leveraging deep industry knowledge to meet client needs and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Unlock potential by driving sales strategy and value analysis, partnering with cross-functional teams to enhance proposals, pricing, and contracts. Lead market research and client engagement to optimi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $195K *

Drive change management initiatives that enhance employee engagement and operational efficiency. Collaborate across teams to ensure successful adoption of technology and policy changes, while providin...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$143K - $291K *

Join a team that's dedicated to empowering healthcare professionals through innovative medical devices. Lead a high-performing sales organization, drive revenue growth, and enhance patient care with c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$68K - $105K *

Transform your career by configuring and supporting Epic applications. Engage in systems analysis, design, and problem resolution while collaborating with end-users to enhance their experience and str...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$207K - $277K *

Lead the charge in enhancing global ERP delivery excellence, driving governance, quality, and continuous improvement across teams. Foster collaboration and optimize resource utilization to ensure pred...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$63K - $96K *

Engage in the support and optimization of multi-user operating systems and applications, collaborating with users and IT teams to enhance system functionality and ensure effective use of technology ac...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$278K - $361K *

Accelerate progress at the forefront of software engineering leadership, driving innovation and operational excellence in regulated medical technology. Lead teams to deliver scalable, high-quality sof...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Healthcare

$162K - $228K *

Transform the Ad Tech landscape by leading cross-functional teams to ensure seamless delivery and execution of complex technology portfolios, driving strategic initiatives and fostering collaboration...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$74K - $124K *

Lead audit remediation initiatives by coordinating with stakeholders, analyzing findings, and developing strategies to enhance internal controls and audit readiness, ensuring successful outcomes for f...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$142K - $202K *

Unlock commercial potential by executing transformation workstreams, collaborating with cross-functional teams, and delivering strategic insights to drive measurable results in a healthcare-focused en...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$77K - $121K *

Join a team that's redefining coding excellence by leading operational strategies, managing staff performance, and ensuring compliance in inpatient coding processes to enhance efficiency and quality a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $162K *

Lead enhancements in Salesforce HealthCloud to optimize solutions and integrations, collaborate with teams, and deliver scalable applications that ensure high-quality data and security compliance for...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $150K *

Accelerate growth by managing sales strategies across CA and parts of the Midwest. Lead market development efforts, achieve sales goals, and collaborate with cross-functional teams to enhance customer...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$184K - $254K *

Shape the future of Procurement by leading enterprise capabilities that enhance performance, streamline processes, and drive technology integration, ensuring measurable value and strategic alignment a...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Healthcare

$170K - $185K *

Join a dynamic team to define and lead product strategy for Family Building Navigation, enhancing member engagement through innovative digital experiences and personalized support while collaborating...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.