Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Gastroenterologist Jobs in South Dakota

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$147K - $251K *

Unlock potential by driving revenue growth within U.S. Federal Government accounts. Engage stakeholders, execute account strategies, and ensure customer satisfaction through adoption and retention of...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Unlock health equity and quality improvement by leading strategic initiatives that enhance outcomes and reduce disparities across diverse populations in value-based care settings. Collaborate with sta...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$180K - $215K *

Unlock potential by leading regional sales efforts for a groundbreaking product. Drive performance through strategic execution, team leadership, and customer engagement in a fast-paced, entrepreneuria...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$250K - $300K *

Partner with us to provide expert breast imaging interpretation in a fully remote setting. Enjoy flexible scheduling and a supportive team environment while contributing to exceptional patient care ac...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$220K - $240K *

Drive strategic growth and operational excellence in a B2B SaaS environment, overseeing P&L, leading a diverse team, and integrating scalable subscription models with custom enterprise solutions to en...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$97K - $145K *

Join a team that's dedicated to ensuring accurate coding and compliance for clinical services, leveraging your expertise to enhance revenue cycle management and contribute to optimal healthcare outcom...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$207K - $284K *

Elevate strategic partnerships in the healthcare diagnostics sector, driving innovative solutions and collaboration across teams. Lead high-impact initiatives that align customer needs with Siemens He...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$88K - $140K *

Shape the future of public service by leading technology consulting projects that enhance operational efficiency and strategic goals for state and local agencies, ensuring compliance and delivering im...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$175K - $195K *

Lead the charge in shaping enterprise data architecture, ensuring scalable, secure access across systems. Collaborate with engineering teams to deliver impactful data solutions that drive business val...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Transform customer success by driving adoption and value realization for advisory teams. Collaborate cross-functionally to enhance workflows and deliver measurable outcomes, ensuring clients achieve e...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $180K *

Reimagine client partnerships by managing complex relationships, driving performance, and leading recovery strategies. Collaborate with executives to ensure client success and identify growth opportun...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$350K - $430K *

Join a team that's at the forefront of ophthalmic genetic medicine development. Provide strategic oversight for clinical studies, ensuring patient safety and data integrity while collaborating with cr...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Innovate data-driven product strategies by leading informatics initiatives, ensuring rigorous testing and quality assessments while collaborating across teams to enhance client services and streamline...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$100K - $231K *

Advance your career by leading healthcare analytics initiatives that transform data into impactful insights, drive performance, and enhance decision-making across departments while fostering innovatio...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$176K - $243K *

Unlock potential by leading strategic initiatives in cardiovascular imaging, driving adoption of advanced technologies, and fostering partnerships to enhance patient care and clinical outcomes across...

RemoteRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Healthcare

$90K - $110K *

Advance national account strategies and sales growth through effective relationship building and business planning. Collaborate across teams to negotiate contracts, leverage competitive advantages, an...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$137K - $185K *

Drive the execution of complex projects, ensuring alignment across global teams. Collaborate with stakeholders to manage risks, track progress, and deliver key medical strategies while fostering cross...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$92K - $110K *

Join a team that's dedicated to enhancing software quality and reliability. As a Business Analyst, you'll collaborate with cross-functional teams to gather requirements, facilitate Agile processes, an...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$83K - $112K *

Partner with us to navigate complex patient cases and ensure seamless access to care. Utilize critical thinking and communication skills to manage authorizations and appeals, collaborating with divers...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$300K - $500K+*

Join a dynamic team as a senior leader driving portfolio performance across the eastern U.S. Oversee regional execution, manage a team of directors, and collaborate on national strategies to enhance b...

RemoteRemote

Today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$78K - $108K *

Empower our growth by managing and negotiating sales contracts, collaborating with cross-functional teams to ensure compliance and efficiency. Your expertise will drive impactful solutions in a dynami...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Consumer Technology

$130K - $160K *

Discover your potential as you drive enterprise sales in the CPG sector, building relationships with iconic brands. Leverage insights and solutions to develop strategies that enhance client success an...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

$150K - $279K *

Transform local government sales by proactively building relationships, generating pipeline, and driving revenue through innovative cloud solutions. Collaborate with a world-class sales team to exceed...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Media

$160K - $195K *

Engage with healthcare payer clients to architect integrated solutions, driving revenue growth through strategic discovery, technical leadership, and value engineering. Collaborate across teams to del...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Healthcare

$215K - $240K *

Shape the future of commercial operations by leading strategy, workflows, and data integration. Collaborate with senior leaders to enhance brand performance and drive operational excellence across cro...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.