Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$150K - $180K *
Champion growth by leading national accounts, driving strategy, and enhancing partnerships with specialty distributors and GPOs. Leverage expertise to ensure product availability and exceed corporate...
3 weeks ago
Senior Principal Consultant, Medicaid Programs
$158K - $185K *
Unlock your potential by leading the design and delivery of a transformative Medicaid data platform. Collaborate with stakeholders and guide teams to modernize healthcare systems through innovative cl...
1 week ago
Senior Director, Quality Assurance (Remote)
$225K - $275K *
Optimize quality assurance processes to ensure compliance with regulatory standards and drive improvements across all operations. Lead a talented team to establish and maintain an effective Quality Ma...
Reposted 3 days ago
Senior Manager, Medical Information and Medical Capabilities
$130K - $155K *
Elevate your career by joining a dynamic Medical Affairs team, where you'll lead Medical Information initiatives, ensure compliance, and drive strategic insights to support our innovative pipeline in...
3 weeks ago
Regional Sales Director - San Francisco
$180K - $215K *
Drive regional sales success by leading a high-performing team, executing launch strategies, and fostering customer relationships to achieve business objectives in a dynamic environment...
1 week ago
Telehealth Psychiatric Nurse Practitioner - Eating Disorders (EST - Remote)
$120K - $150K *
Join a team that's dedicated to transforming the mental health landscape, providing comprehensive telehealth care for individuals with eating disorders while collaborating closely with a multidiscipli...
Reposted 4 weeks ago
Senior Director, Corporate Sales
$212K - $270K *
Drive growth and strategy as a Senior Director, leading a high-performing sales team to achieve exceptional results in a dynamic, fast-paced environment focused on new business and expansion across di...
3 weeks ago
Customer Support Manager, Provider Enablement
$80K - $95K *
Drive customer support excellence by managing a frontline team to ensure timely resolutions, operational efficiency, and a culture of continuous improvement, paving the way for stellar service in heal...
Reposted today
Sr. Staff Engineer (Fullstack/Backend)
$150K - $180K *
Lead the charge in architectural innovation and strategic direction, shaping long-term technical landscapes and enabling cross-functional execution at scale while mentoring senior technical leaders an...
3 weeks ago
$120K - $150K *
Empower a healthcare association by leading strategic initiatives, fostering partnerships, and driving revenue growth. Collaborate with stakeholders to enhance program excellence and ensure effective...
3 weeks ago
Clinical Pharmacist (Formulary & Quality)
$107K - $199K *
Redefine pharmacy care by developing formularies and policies, enhancing quality programs, and driving initiatives that improve Medicaid services while collaborating with diverse teams and stakeholder...
4 weeks ago
$378K - $420K *
Transform pharmacovigilance by leading a dedicated team, enhancing systems, and ensuring compliance across clinical and commercial products while driving safety strategy and governance...
4 weeks ago
Senior Oncology Account Manager, Philadelphia
$150K - $230K *
Drive impactful oncology solutions by building relationships with key stakeholders. Leverage your expertise to exceed performance goals and enhance patient access to innovative therapies while managin...
1 week ago
Senior Manager, Global Scientific Communications & Engagement Strategy- Content Lead
$141K - $191K *
Champion high-impact scientific communication strategies, collaborating across Medical Affairs and Commercial. Lead content development, enhance engagement, and drive operational excellence for effect...
1 month ago
$160K - $190K *
Transform ambiguity into action by driving strategic initiatives across functions. Collaborate with executives to architect programs that enhance operational efficiency and deliver measurable business...
3 weeks ago
Head of Analytical Development, Pulmovant
$160K - $200K *
Lead the charge in analytical development, overseeing drug substance and product strategies. Collaborate across teams to ensure compliance and performance, while mentoring a high-performing analytical...
2 weeks ago
Assoc Dir, Neuro Thought Leader Liaison (Midwest Region)
$190K - $225K *
Transform relationships with key opinion leaders in rare neurological diseases, providing strategic insights and guidance to inform brand strategies and enhance engagement across medical and commercia...
Reposted 3 days ago
Director, Identity Governance and Workforce Protection
$150K - $180K *
Elevate the security landscape by leading identity governance and workforce protection initiatives. Drive strategic direction, oversee technical teams, and ensure compliance while enhancing identity s...
Today
Senior Customer Succes Manager
$110K - $130K *
Pioneer customer success by nurturing strategic relationships, driving product adoption, and ensuring satisfaction. Leverage your expertise to mentor junior team members and shape customer success str...
3 weeks ago
Technical Implementation Specialist
$100K - $110K *
Drive the implementation and support of cutting-edge software solutions in Cell & Gene Therapy. Collaborate with diverse teams to translate customer needs into actionable plans, ensuring seamless inte...
3 weeks ago
Senior Medical Science Liaison, Central (Multiple Territories)
$190K - $220K *
Champion impactful scientific engagement by building relationships with key stakeholders, translating clinical data into actionable insights, and driving prelaunch strategies in a dynamic environment...
1 week ago
$150K - $180K *
Develop and lead revenue operations to drive strategic growth, optimizing marketing, sales, and customer interactions while building a high-performing team and implementing scalable processes and tech...
Reposted 4 weeks ago
$80K - $95K *
Drive analytical solutions by leading projects, applying advanced data analysis, and collaborating with clients to deliver actionable insights across energy initiatives including efficiency and sustai...
4 weeks ago
$80K - $95K *
Transform inpatient coding operations by leading a dedicated team to ensure accurate coding, compliance, and timely billing. Collaborate with clinical and administrative staff to enhance financial per...
Yesterday
Director of Reimbursement & Regulatory Analysis
$125K - $150K *
Optimize reimbursement strategies and regulatory compliance by leading analysis, developing policies, and mentoring teams. Drive operational excellence and foster relationships with stakeholders to en...
Today
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.